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European Archives of Oto-Rhino-Laryngology

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10-05-2022 | Bilateral Vestibulopathy | Otology

Sound localization in patients with bilateral vestibulopathy

Authors: Olivier Peetermans, Bieke Dobbels, Griet Mertens, Julie Moyaert, Raymond van de Berg, Olivier Vanderveken, Paul Van de Heyning, Angélica Pérez Fornos, Nils Guinand, Marc J. W. Lammers, Vincent Van Rompaey

Published in: European Archives of Oto-Rhino-Laryngology | Issue 12/2022

Abstract

Purpose

The goal of this study was to evaluate if bilaterally (partially) absent vestibular function during static sound localization testing, would have a negative impact on sound localization skills. Therefore, this study compared horizontal static sound localization skills of normal-hearing patients with bilateral vestibulopathy (BV) and healthy controls.

Methods

Thirteen normal-hearing patients with BV and thirteen age-matched healthy controls were included. Sound localization skills were tested using seven loudspeakers in a frontal semicircle, ranging from − 90° to + 90°. Sound location accuracy was analyzed using the root-mean-square error (RMSE) and the mean absolute error (MAE). To evaluate the severity of the BV symptoms, the following questionnaires were used: Dizziness Handicap Inventory (DHI), Oscillopsia severity questionnaire (OSQ), 12-item Spatial, Speech, and Qualities Questionnaire (SSQ12), and Health Utilities Index Mark 3 (HUI3).

Results

The RMSE and MAE were significantly larger (worse) in the BV group than in the healthy control group, with respective median RMSE of 4.6° and 0°, and a median MAE of 0.7° and 0°. The subjective reporting of speech perception, spatial hearing, and quality of life only demonstrated a moderate correlation between DHI (positive correlation) and HUI total score (negative correlation), and localization scores.

Conclusion

Static sound localization skills of patients with BV were only mildly worse compared to healthy controls. However, this difference was very small and therefore most likely due to impaired cognitive function. The vestibular system does not seem to have a modulating role in sound localization during static conditions, and its impact is negligible in contrast to the impact of hearing impairment. Furthermore, the subjective reporting of speech perception, spatial hearing, and quality of life was not strongly correlated with localization scores.

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Driver EC, Kelley MW (2020) Development of the cochlea. Development 147:1–13. https://doi.org/10.1242/dev.162263CrossRef

Flourens P (1842) Expériences sur les canaux semi-circulaires des oiseaux. In: Baillière JB (ed) Recherches Expérimentales Sur Les Propriétés Et Les Fonctions Du Système Nerveux Les Animaux Vertébrès, 2nd edn. Imprimerie de Bourgogne et Martinet, Paris, pp 454–468

Dobbels B, Mertens G, Gilles A et al (2019) Cognitive function in acquired bilateral vestibulopathy: a cross-sectional study on cognition, hearing, and vestibular loss. Front Neurosci 13:340. https://doi.org/10.3389/fnins.2019.00340CrossRef

Dobbels B, Peetermans O, Boon B et al (2019) Impact of bilateral vestibulopathy on spatial and nonspatial cognition: a systematic review. Ear Hear 40:757–765. https://doi.org/10.1097/AUD.0000000000000679CrossRef

Kremmyda O, Hufner K, Flanagin VL et al (2016) Beyond dizziness: virtual navigation, spatial anxiety and hippocampal volume in bilateral vestibulopathy. Front Hum Neurosci 10:139. https://doi.org/10.3389/fnhum.2016.00139CrossRef

Strupp M, Kim JS, Murofushi T et al (2017) Bilateral vestibulopathy: diagnostic criteria consensus document of the classification committee of the barany society. J Vestib Res 27:177–189. https://doi.org/10.3233/VES-170619CrossRef

Mills AW (1958) On the minimum audible angle. J Acoust Soc Am 30:237. https://doi.org/10.1121/1.1909553CrossRef

Slattery WH 3rd, Middlebrooks JC (1994) Monaural sound localization: acute versus chronic unilateral impairment. Hear Res 75:38–46. https://doi.org/10.1016/0378-5955(94)90053-1CrossRef

Nilsson ME, Schenkman BN (2016) Blind people are more sensitive than sighted people to binaural sound-location cues, particularly inter-aural level differences. Hear Res 332:223–232. https://doi.org/10.1016/j.heares.2015.09.012CrossRef

10.

Tollin DJ, Ruhland JL, Yin TC (2009) The vestibulo-auricular reflex. J Neurophysiol 101:1258–1266. https://doi.org/10.1152/jn.90977.2008CrossRef

11.

Genzel D, Firzlaff U, Wiegrebe L et al (2016) Dependence of auditory spatial updating on vestibular, proprioceptive, and efference copy signals. J Neurophysiol 116:765–775. https://doi.org/10.1152/jn.00052.2016CrossRef

12.

Stein B, Stanford T (2008) Multisensory integration: current issues from the perspective of the single neuron. Nat Rev Neurosci 9:255–266. https://doi.org/10.1038/nrn2331CrossRef

13.

DiZio P, Held R, Lackner JR et al (2001) Gravitoinertial force magnitude and direction influence head-centric auditory localization. J Neurophysiol 85:2455–2460. https://doi.org/10.1152/jn.2001.85.6.2455CrossRef

14.

Leung J, Alais D, Carlile S (2008) Compression of auditory space during rapid head turns. Proc Natl Acad Sci USA 105:6492–6497. https://doi.org/10.1073/pnas.0710837105CrossRef

15.

Teramoto W, Sakamoto S, Furune F et al (2012) Compression of auditory space during forward self-motion. PLoS One 7:e39402. https://doi.org/10.1371/journal.pone.0039402CrossRef

16.

Lackner JR, DiZio P (2010) Audiogravic and oculogravic illusions represent a unified spatial remapping. Exp Brain Res 202:513–518. https://doi.org/10.1007/s00221-009-2149-yCrossRef

17.

Lewald J, Karnath HO (2002) The effect of whole-body tilt on sound lateralization. Eur J Neurosci 16:761–766. https://doi.org/10.1046/j.1460-9568.2002.02117.xCrossRef

18.

Freigang C, Richter N, Rubsamen R et al (2015) Age-related changes in sound localisation ability. Cell Tissue Res 361:371–386. https://doi.org/10.1007/s00441-015-2230-8CrossRef

19.

Mertens G, Gilles A, Bouzegta R et al (2018) A prospective randomized crossover study in single sided deafness on the new non-invasive adhesive bone conduction hearing system. Otol Neurotol 39:940–949. https://doi.org/10.1097/MAO.0000000000001892CrossRef

20.

Van Der Stappen A, Wuyts FL, Van De Heyning PH (2000) Computerized electronystagmography: normative data revisited. Acta Otolaryngol 120:724–730. https://doi.org/10.1080/000164800750000243CrossRef

21.

Macdougall HG, McGarvie LA, Halmagyi GM et al (2013) The video Head Impulse Test (vHIT) detects vertical semicircular canal dysfunction. PLoS ONE 8:e61488. https://doi.org/10.1371/journal.pone.0061488CrossRef

22.

Colebatch JG, Halmagyi GM, Skuse NF (1994) Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 57:190–197. https://doi.org/10.1136/jnnp.57.2.190CrossRef

23.

Jacobson GP, Newman CW (1990) The development of the Dizziness Handicap Inventory. Arch Otolaryngol Head Neck Surg 116:424–427. https://doi.org/10.1001/archotol.1990.01870040046011CrossRef

24.

Guinand N, Pijnenburg M, Janssen M et al (2012) Visual acuity while walking and oscillopsia severity in healthy subjects and patients with unilateral and bilateral vestibular function loss. Arch Otolaryngol Head Neck Surg 138:301–306. https://doi.org/10.1001/archoto.2012.4CrossRef

25.

Anson ER, Gimmon Y, Kiemel T et al (2018) A tool to quantify the functional impact of oscillopsia. Front Neurol 9:142. https://doi.org/10.3389/fneur.2018.00142CrossRef

26.

Noble W, Jensen NS, Naylor G et al (2013) A short form of the Speech, Spatial and Qualities of Hearing scale suitable for clinical use: the SSQ12. Int J Audiol 52:409–412. https://doi.org/10.3109/14992027.2013.781278CrossRef

27.

Banh JG, Singh G, Pichora-Fuller MK (2012) Age affects responses on the Speech, Spatial, and Qualities of Hearing Scale (SSQ) by adults with minimal audiometric loss. J Am Acad Audiol 23:81–91. https://doi.org/10.3766/jaaa.23.2.2CrossRef

28.

Horsman J, Furlong W, Feeny D et al (2003) The Health Utilities Index (HUI): concepts, measurement properties and applications. Health Qual Life Outcomes 1:54. https://doi.org/10.1186/1477-7525-1-54CrossRef

29.

Luo N, Johnson JA, Shaw JW et al (2005) Self-reported health status of the general adult U.S. population as assessed by the EQ-5D and Health Utilities Index. Med Care 43:1078–1086. https://doi.org/10.1097/01.mlr.0000182493.57090.c1CrossRef

30.

Faul F, Erdfelder E, Buchner A et al (2009) Statistical power analyses using G*Power 3.1: tests for correlation and regression analyses. Behav Res Methods 41:1149–1160. https://doi.org/10.3758/BRM.41.4.1149CrossRef

31.

Mertens G, Desmet J, De Bodt M et al (2016) Prospective case-controlled sound localisation study after cochlear implantation in adults with single-sided deafness and ipsilateral tinnitus. Clin Otolaryngol 41:511–518. https://doi.org/10.1111/coa.12555CrossRef

32.

Lewald J, Karnath HO (2000) Vestibular influence on human auditory space perception. J Neurophysiol 84:1107–1111. https://doi.org/10.1046/j.1460-9568.2002.02117.xCrossRef

33.

Livingston G, Sommerlad A, Orgeta V et al (2017) Dementia prevention, intervention, and care. Lancet 390:2673–2734. https://doi.org/10.1016/S0140-6736(17)31363-6CrossRef

34.

Keating P, King AJ (2013) Developmental plasticity of spatial hearing following asymmetric hearing loss: context-dependent cue integration and its clinical implications. Front Syst Neurosci 7:123. https://doi.org/10.3389/fnsys.2013.00123CrossRef

35.

Kumpik DP, King AJ (2019) A review of the effects of unilateral hearing loss on spatial hearing. Hear Res 372:17–28. https://doi.org/10.1016/j.heares.2018.08.003CrossRef

36.

Brandt T, Schautzer F, Hamilton DA et al (2005) Vestibular loss causes hippocampal atrophy and impaired spatial memory in humans. Brain 128:2732–2741. https://doi.org/10.1093/brain/awh617CrossRef

37.

Glasauer S, Amorim MA, Viaud-Delmon I et al (2002) Differential effects of labyrinthine dysfunction on distance and direction during blindfolded walking of a triangular path. Exp Brain Res 145:489–497. https://doi.org/10.1007/s00221-002-1146-1CrossRef

38.

Glasauer S, Amorim MA, Vitte E et al (1994) Goal-directed linear locomotion in normal and labyrinthine-defective subjects. Exp Brain Res 98:323–335. https://doi.org/10.1007/BF00228420CrossRef

39.

Grabherr L, Cuffel C, Guyot JP et al (2011) Mental transformation abilities in patients with unilateral and bilateral vestibular loss. Exp Brain Res 209:205–214. https://doi.org/10.1007/s00221-011-2535-0CrossRef

40.

Bessot N, Denise P, Toupet M et al (2012) Interference between walking and a cognitive task is increased in patients with bilateral vestibular loss. Gait Posture 36:319–321. https://doi.org/10.1016/j.gaitpost.2012.02.021CrossRef

41.

Popp P, Wulff M, Finke K et al (2017) Cognitive deficits in patients with a chronic vestibular failure. J Neurol 264:554–563. https://doi.org/10.1007/s00415-016-8386-7CrossRef

42.

Claes AJ, Mertens G, Gilles A et al (2016) The repeatable battery for the assessment of neuropsychological status for hearing impaired individuals (RBANS-H) before and after cochlear implantation: a protocol for a prospective. Longitudinal Cohort Study Front Neurosci 10:512. https://doi.org/10.3389/fnins.2016.00512CrossRef

43.

Dobbels B, Lucieer F, Mertens G et al (2020) Prospective cohort study on the predictors of fall risk in 119 patients with bilateral vestibulopathy. PLoS One 15:e0228768. https://doi.org/10.1371/journal.pone.0228768CrossRef

44.

Hallemans A, Mertens G, Van de Heyning P et al (2017) Playing music may improve the gait pattern in patients with bilateral caloric areflexia wearing a cochlear implant: results from a pilot study. Front Neurol 8:404. https://doi.org/10.3389/fneur.2017.00404CrossRef

45.

Zhong X, Yost WA (2013) Relationship between postural stability and spatial hearing. J Am Acad Audiol 24:782–788. https://doi.org/10.3766/jaaa.24.9.3CrossRef

46.

Rumalla K, Karim AM, Hullar TE (2015) The effect of hearing aids on postural stability. Laryngoscope 125:720–723. https://doi.org/10.1002/lary.24974CrossRef

47.

Lucieer FMP, Van Hecke R, van Stiphout L et al (2020) Bilateral vestibulopathy: beyond imbalance and oscillopsia. J Neurol 267:241–255. https://doi.org/10.1007/s00415-020-10243-5CrossRef

48.

Guinand N, Boselie F, Guyot JP et al (2012) Quality of life of patients with bilateral vestibulopathy. Ann Otol Rhinol Laryngol 121:471–477. https://doi.org/10.1177/000348941212100708CrossRef

Title: Sound localization in patients with bilateral vestibulopathy
Authors: Olivier Peetermans
Bieke Dobbels
Griet Mertens
Julie Moyaert
Raymond van de Berg
Olivier Vanderveken
Paul Van de Heyning
Angélica Pérez Fornos
Nils Guinand
Marc J. W. Lammers
Vincent Van Rompaey
Publication date: 10-05-2022
Publisher: Springer Berlin Heidelberg
Keyword: Bilateral Vestibulopathy
Published in: European Archives of Oto-Rhino-Laryngology / Issue 12/2022
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-022-07414-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Sound localization in patients with bilateral vestibulopathy

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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