Top

Published in:

01-10-2018 | Review

Beyond Conventional Medicine - a Look at Blueberry, a Cancer-Fighting Superfruit

Authors: Kristoffer T. Davidson, Ziwen Zhu, Dean Balabanov, Lei Zhao, Mark R. Wakefield, Qian Bai, Yujiang Fang

Published in: Pathology & Oncology Research | Issue 4/2018

Abstract

Nearly 40% of men and women will be diagnosed with cancer during their lifetime. Thus, there is a rapidly growing need for novel therapies to combat this deadly disease. One such method is the consumption of blueberries. Long coveted for their powerful antioxidant properties, more recent studies have demonstrated that blueberries also exhibit inherent abilities to prevent carcinogenesis, inhibit the proliferation of neoplastic cells, and reduce the risks of recurrence in patients in remission. This review will focus on the specific activities of blueberry derivatives in cancer cells across many different forms of cancer. Ultimately, such research could be helpful in the development of new strategies to treat cancer.

Siegel RL, Miller KD, Jemal A (2017) Cancer statistics, 2017. CA Cancer J Clin 67(1):7–30. https://doi.org/10.3322/caac.21387 CrossRefPubMed

Slattery ML, Lundgreen A, Torres-Mejia G, Wolff RK, Hines L, Baumgartner K, John EM (2014) Diet and lifestyle factors modify immune/inflammation response genes to alter breast cancer risk and prognosis: the breast cancer health disparities study. Mutat Res Fundam Mol Mech Mutagen 770:19–28CrossRef

Lee G-Y, Lee JJ, Lee S-M (2015) Antioxidant and anticoagulant status were improved by personalized dietary intervention based on biochemical and clinical parameters in cancer patients. Nutr Cancer 67(7):1083–1092CrossRefPubMed

Nandakumar V, Singh T, Katiyar SK (2008) Multi-targeted prevention and therapy of cancer by proanthocyanidins. Cancer Lett 269(2):378–387CrossRefPubMedPubMedCentral

Kresty LA, Weh KM, Zeyzus-Johns B, Perez LN, Howell AB (2015) Cranberry proanthocyanidins inhibit esophageal adenocarcinoma in vitro and in vivo through pleiotropic cell death induction and PI3K/AKT/mTOR inactivation. Oncotarget 6(32):33438CrossRefPubMedPubMedCentral

Jeyabalan J, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC (2014) Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer. J Agric Food Chem 62(18):3963–3971CrossRefPubMed

Chen C, Li Y, Xu Z (2010) Chemical principles and bioactivities of blueberry. Yao xue xue bao=Acta Pharm Sin 45(4):422–429

Johnson SA, Arjmandi BH (2013) Evidence for anti-cancer properties of blueberries: a mini-review. Anticancer Agents Med (Formerly Curr Med Chem: Anti-Cancer Agents) 13(8):1142–1148CrossRef

Howlader N, Noone A, Krapcho M, Garshell J, Neyman N, Altekruse S, Kosary C, Yu M, Ruhl J, Tatalovich Z (2013) SEER cancer statistics review, Natl Cancer Inst. Bethesda (1975–2010)

10.

Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S (2010) Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res 70(9):3594–3605CrossRefPubMedPubMedCentral

11.

Montales MTE, Rahal OM, Kang J, Rogers T, Prior RL, Wu X, Simmen RC (2012) Repression of mammosphere formation of human breast cancer cells by soy isoflavone genistein and blueberry polyphenolic acids suggests diet-mediated targeting of cancer stem-like/progenitor cells. Carcinogenesis 33(3):652–660CrossRefPubMed

12.

Kanaya N, Adams L, Takasaki A, Chen S (2014) Whole blueberry powder inhibits metastasis of triple negative breast cancer in a xenograft mouse model through modulation of inflammatory cytokines. Nutr Cancer 66(2):242–248CrossRefPubMed

13.

Ravoori S, Vadhanam MV, Aqil F, Gupta RC (2012) Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry. J Agric Food Chem 60(22):5547–5555CrossRefPubMed

14.

Bruix J, Sherman M (2011) Management of hepatocellular carcinoma: an update. Hepatology 53(3):1020–1022CrossRefPubMed

15.

Yi W, Akoh CC, Fischer J, Krewer G (2006) Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Food Res Int 39(5):628–638CrossRef

16.

Bingül İ, Başaran-Küçükgergin C, Tekkeşin MS, Olgaç V, Doğru-Abbasoğlu S, Uysal M (2013) Effect of blueberry pretreatment on diethylnitrosamine-induced oxidative stress and liver injury in rats. Environ Toxicol Pharmacol 36(2):529–538CrossRefPubMed

17.

Bingül İ, Başaran-Küçükgergin C, Aydın AF, Soluk-Tekkeşin M, Olgaç V, Doğru-Abbasoğlu S, Uysal M (2015) Blueberry treatment attenuated cirrhotic and preneoplastic lesions and oxidative stress in the liver of diethylnitrosamine-treated rats. Int J Immunopathol Pharmacol 29(3):426–37

18.

Zhan W, Liao X, Yu L, Tian T, Liu X, Liu J, Cai L-J, Xiao X, Xie R-J, Yang Q (2016) Effects of blueberries on migration, invasion, proliferation, the cell cycle and apoptosis in hepatocellular carcinoma cells. Biomedical reports 5(5):579–584CrossRefPubMedPubMedCentral

19.

Yi W, Fischer J, Krewer G, Akoh CC (2005) Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 53(18):7320–7329CrossRefPubMed

20.

Suh N, Paul S, Hao X, Simi B, Xiao H, Rimando AM, Reddy BS (2007) Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 13(1):350–355CrossRefPubMed

21.

Minker C, Duban L, Karas D, Järvinen P, Lobstein A, Muller CD (2015) Impact of procyanidins from different berries on caspase 8 activation in colon cancer. Oxidative Med Cell Longev 2015:1–13CrossRef

22.

Qi C, Li S, Jia Y, Wang L (2014) [Blueberry anthocyanins induce G2/M cell cycle arrest and apoptosis of oral cancer KB cells through down-regulation methylation of p53]. Yi chuan= Hereditas/Zhongguo yi chuan xue hui bian ji 36 (6):566–573

23.

Baba AB, Kowshik J, Krishnaraj J, Sophia J, Dixit M, Nagini S (2016) Blueberry inhibits invasion and angiogenesis in 7, 12-dimethylbenz [a] anthracene (DMBA)-induced oral squamous cell carcinogenesis in hamsters via suppression of TGF-β and NF-κB signaling pathways. J Nutr Biochem 35:37–47CrossRefPubMed

24.

Schmidt BM, Erdman JW, Lila MA (2006) Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines. Cancer Lett 231(2):240–246CrossRefPubMed

25.

Matchett MD, MacKinnon SL, Sweeney MI, Gottschall-Pass KT, Hurta RA (2006) Inhibition of matrix metalloproteinase activity in DU145 human prostate cancer cells by flavonoids from lowbush blueberry (Vaccinium Angustifolium): possible roles for protein kinase C and mitogen-activated protein-kinase-mediated events. J Nutr Biochem 17(2):117–125CrossRefPubMed

26.

Kausar H, Jeyabalan J, Aqil F, Chabba D, Sidana J, Singh IP, Gupta RC (2012) Berry anthocyanidins synergistically suppress growth and invasive potential of human non-small-cell lung cancer cells. Cancer Lett 325(1):54–62CrossRefPubMed

27.

Diaconeasa Z, Leopold L, Rugină D, Ayvaz H, Socaciu C (2015) Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice. Int J Mol Sci 16(2):2352–2365CrossRefPubMedPubMedCentral

28.

Bunea A, Rugină D, Sconţa Z, Pop RM, Pintea A, Socaciu C, Tăbăran F, Grootaert C, Struijs K, VanCamp J (2013) Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells. Phytochemistry 95:436–444CrossRefPubMed

29.

Davidson KT, Zhu Z, Bai Q, Xiao H, Wakefield MR, Fang Y (2017) Blueberry as a potential Radiosensitizer for treating cervical cancer. Pathol Oncol Res 22(4):655–60

30.

Fang Y, Moore BJ, Bai Q, Cook KM, Herrick EJ, Nicholl MB (2013) Hydrogen peroxide enhances radiation-induced apoptosis and inhibition of melanoma cell proliferation. Anticancer Res 33(5):1799–1807PubMed

31.

Fang Y, Bradley MJ, Cook KM, Herrick EJ, Nicholl MB (2013) A potential role for resveratrol as a radiation sensitizer for melanoma treatment. J Surg Res 183(2):645–653CrossRefPubMed

32.

Fang Y, DeMarco VG, Nicholl MB (2012) Resveratrol enhances radiation sensitivity in prostate cancer by inhibiting cell proliferation and promoting cell senescence and apoptosis. Cancer Sci 103(6):1090–1098CrossRefPubMedPubMedCentral

33.

Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK (2009) Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antioxid Redox Signal 11(1):47–58CrossRefPubMedPubMedCentral

34.

Kai H, Akamatsu E, Torii E, Kodama H, Yukizaki C, Sakakibara Y, Suiko M, Morishita K, Kataoka H, Matsuno K (2011) Inhibition of proliferation by agricultural plant extracts in seven human adult T-cell leukaemia (ATL)-related cell lines. J Nat Med 65(3–4):651–655CrossRefPubMed

Title: Beyond Conventional Medicine - a Look at Blueberry, a Cancer-Fighting Superfruit
Authors: Kristoffer T. Davidson
Ziwen Zhu
Dean Balabanov
Lei Zhao
Mark R. Wakefield
Qian Bai
Yujiang Fang
Publication date: 01-10-2018
Publisher: Springer Netherlands
Published in: Pathology & Oncology Research / Issue 4/2018
Print ISSN: 1219-4956
Electronic ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-017-0376-2

Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras

Prof. Fabrice Barlesi

Developed by: Springer Medicine

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2018

Epidermal Growth Factor Receptor (EGFR) Kinase Inhibitors and Non-Small Cell Lung Cancer (NSCLC) – Advances in Molecular Diagnostic Techniques to Facilitate Targeted Therapy

Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer

Stain-free Histopathology of Basal Cell Carcinoma by Dual Vibration Resonance Frequency CARS Microscopy

Anti-Diabetic Drugs: Cure or Risk Factors for Cancer?

Re-Appraisal of Estrogen Receptor Negative/Progesterone Receptor Positive (ER−/PR+) Breast Cancer Phenotype: True Subtype or Technical Artefact?

Overexpression of FZD1 and CAIX are Associated with Invasion, Metastasis, and Poor-Prognosis of the Pancreatic Ductal Adenocarcinoma

Keynote webinar | Spotlight on antibody–drug conjugates in cancer