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Clinical Oral Investigations

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Open Access 02-10-2023 | Bevacizumab | Research

Influence of antiresorptive/antiangiogenic therapy on the surgical treatment outcomes of experimentally induced peri-implantitis lesions

Authors: Ausra Ramanauskaite, Nadine Krüger, Karina Obreja, Fanya Borchert, Iulia Dahmer, Frank Schwarz

Published in: Clinical Oral Investigations | Issue 11/2023

Abstract

Objective

To investigate the influence of various antiresorptive and antiangiogenic medications on the resolution of experimentally induced peri-implantitis lesions after different surgical treatment approaches.

Materials and methods

Forty-eight albino rats randomly received a dual application of the following medications: (1) amino-bisphosphonate (zoledronate (Zo)) (n = 8), (2) RANKL inhibitor (denosumab (De)) (n = 8), (3) antiangiogenic (bevacizumab (Be)) (n = 8), (4) Zo + Be (n = 8), (5) De + Be (n = 8), or (6) no medication (control (Co)) (n = 8). Ligature-induced peri-implantitis lesions were established at 2 maxillary implants over 16 weeks. Afterward, animals were randomly treated either with open flap debridement (OFD) or reconstructive therapy (RT). Treatment procedures were followed by a 12-week healing period. The histological outcomes included residual defect length (DL); defect width (DW) at the bone crest (BC-DW); 25%, 50%, and 75% of the DL; and areas of inflammatory cell infiltrate (ICT). When present, areas of bone sequester (BS) were assessed considering the animal as a statistical unit.

Results

A total of 21 animals were analyzed (Zo: RT = 3, OFD = 1; De: RT = 3, OFD = 2; Be: OFD = 1; Zo + Be: RT = 2, OFD = 2; Co: RT = 3, OFD = 2). Implant loss rates were comparable among the experimental groups. Except for the 25% and 75% DW values that were significantly higher in the Zo + Be group compared to the Co group (p = 0.04 and p = 0.03, respectively), no significant differences were found among the experimental groups for the DL (lowest—Be: 0.56 mm; highest—Co: 1.05 mm), BC-DW (lowest—De: 0.86 mm, highest—Co: 1.07 mm), 50% DW (lowest—De: 0.86 mm; highest—Be + Zo: 1.29 mm), and ICT (lowest—Be: 0.56 mm²; highest—Be + Zo: 1.65 mm²). All groups, except for the Zo and Be following RT, showed presence of BS.

Conclusions

The present findings did not reveal a marked effect of various antiresorptive/antiangiogenic medications on the resolution of experimentally induced peri-implantitis lesions, regardless of the surgical approach employed (OFD and RT).

Clinical relevance

Resolution of peri-implantitis lesions may not be affected by the investigated antiresorptive/antiangiogenic medications.

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Title: Influence of antiresorptive/antiangiogenic therapy on the surgical treatment outcomes of experimentally induced peri-implantitis lesions
Authors: Ausra Ramanauskaite
Nadine Krüger
Karina Obreja
Fanya Borchert
Iulia Dahmer
Frank Schwarz
Publication date: 02-10-2023
Publisher: Springer Berlin Heidelberg
Keywords: Bevacizumab
Denosumab
Denosumab
Published in: Clinical Oral Investigations / Issue 11/2023
Print ISSN: 1432-6981
Electronic ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-023-05275-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Influence of antiresorptive/antiangiogenic therapy on the surgical treatment outcomes of experimentally induced peri-implantitis lesions

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Materials and methods

Results

Conclusions

Clinical relevance

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