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01-09-2013 | Original Research

Bevacizumab-based treatment in colorectal cancer with a NRAS Q61K mutation

Authors: Filip Janku, Jennifer J. Wheler, David S. Hong, Razelle Kurzrock

Published in: Targeted Oncology | Issue 3/2013

Abstract

Despite development of new therapies, metastatic colorectal cancer (mCRC) largely remains an incurable disease. Approximately 2–6 % of colorectal cancers harbor NRAS mutations. The anti-VEGF antibody bevacizumab is a backbone of most therapeutic regimens; however, biomarkers predicting its activity are not known. We report two cases of mCRC with a Q61K NRAS mutation that had a favorable response to bevacizumab and the histone deacetylase inhibitor valproic acid. In contrast, none of ten patients with wild-type NRAS or unknown NRAS status and mutated KRAS (NRAS and KRAS mutations are mutually exclusive) responded to the same regimen. These results suggest that NRAS mutation merits further investigation as a potential biomarker predicting the efficacy of bevacizumab-based treatment.

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Title: Bevacizumab-based treatment in colorectal cancer with a NRAS Q61K mutation
Authors: Filip Janku
Jennifer J. Wheler
David S. Hong
Razelle Kurzrock
Publication date: 01-09-2013
Publisher: Springer Paris
Published in: Targeted Oncology / Issue 3/2013
Print ISSN: 1776-2596
Electronic ISSN: 1776-260X
DOI: https://doi.org/10.1007/s11523-013-0266-9

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