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World Journal of Urology

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Open Access 01-11-2020 | Benign Prostatic Hypertrophy | Invited Review

Inflammation is a target of medical treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia

Authors: Cosimo De Nunzio, Andrea Salonia, Mauro Gacci, Vincenzo Ficarra

Published in: World Journal of Urology | Issue 11/2020

Abstract

Purpose

To review the role of a persistent prostatic inflammatory status (PIS) in the development and progression of benign prostatic hyperplasia (BPH) associated with lower urinary tract symptoms (LUTS) and which medical therapies approved for LUTS/BPH may reduce persistent PIS.

Methods

Literature search in PubMed up to July 2019.

Results

The cause of histologically defined persistent PIS or chronic prostatic inflammation is multifactorial. It is evident in many men with LUTS/BPH, particularly in older men and in men with a large prostate volume or more severe (storage) LUTS. Additionally, persistent PIS is associated with an increased risk of acute urinary retention and symptom worsening. Of medical therapies approved for LUTS/BPH, the current evidence for a reduction of persistent PIS is greatest for the hexanic extract of Serenoa repens (HESr). This treatment relieves LUTS to the same extent as α₁-adrenoceptor antagonists and short-term 5α-reductase inhibitors. Limited evidence is available on the effect of other mainstream LUTS/BPH treatments on persistent PIS.

Conclusions

Persistent PIS plays a central role in both the development and progression of LUTS/BPH. In men with LUTS/BPH who have a high chance of harbouring persistent PIS, HESr will not only improve LUTS, but also reduce (underlying) inflammation. Well-designed clinical studies, with a good level of evidence, are required to better evaluate the impact of BPH/LUTS medical therapies on persistent PIS.

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Title: Inflammation is a target of medical treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia
Authors: Cosimo De Nunzio
Andrea Salonia
Mauro Gacci
Vincenzo Ficarra
Publication date: 01-11-2020
Publisher: Springer Berlin Heidelberg
Keywords: Benign Prostatic Hypertrophy
Phytotherapy
Benign Prostatic Hypertrophy
Tamsulosin
Finasteride
Published in: World Journal of Urology / Issue 11/2020
Print ISSN: 0724-4983
Electronic ISSN: 1433-8726
DOI: https://doi.org/10.1007/s00345-020-03106-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Inflammation is a target of medical treatment for lower urinary tract symptoms associated with benign prostatic hyperplasia

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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