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Published in: Trials 1/2022

Open Access 01-12-2022 | Benign Paroxysmal Positional Vertigo | Study protocol

Internet-based vestibular rehabilitation versus standard care after acute onset vertigo: a study protocol for a randomized controlled trial

Authors: Solmaz Surano, Helena Grip, Fredrik Öhberg, Marcus Karlsson, Erik Faergemann, Maria Bjurman, Hugo Davidsson, Torbjörn Ledin, Ellen Lindell, Jan Mathé, Fredrik Tjernström, Tatjana Tomanovic, Gabriel Granåsen, Jonatan Salzer

Published in: Trials | Issue 1/2022

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Abstract

Background

Dizziness and vertigo affect around 15% of adults annually and represent common reasons for contacting health services, accounting for around 3% of all emergency department visits worldwide. Vertigo is also associated with excessive use of diagnostic imaging and emergency care and decreased productivity, primarily because of work absenteeism. Vestibular rehabilitation is an evidence-based treatment for chronic dizziness and supervised group exercise therapy has recently been shown to be effective after vestibular neuritis, a common cause of acute onset vertigo. However, such interventions are not readily available and there is a need for more easily accessible tools. The purpose of this study is to investigate the effects on vestibular symptoms of a 6-week online vestibular rehabilitation tool after acute onset vertigo, with the aim of aiding vestibular rehabilitation by presenting a more accessible tool that can help to reduce recovery time.

Methods

Three hundred twenty individuals diagnosed with acute vestibular syndrome (AVS) will be recruited from multiple hospitals in Sweden and the effects of an online vestibular rehabilitation tool, YrselTräning, on vestibular symptoms after acute onset vertigo will be compared to standard care (written instructions leaflet) in a two-armed, evaluator-blinded, multicenter randomized controlled trial. The primary outcome will be the Vertigo Symptom Scale Short Form (VSS-SF) score at 6 weeks after symptom onset. Secondary outcomes include effects of the intervention on activities of daily living, mood and anxiety, vestibular function recovery, mobility measures, health economic effects, and the reliability of the Swedish VSS-SF translation.

Discussion

Participants using the online vestibular rehabilitation tool are expected to recover earlier and to a greater extent from their symptoms as compared to standard care. Since up to 50% of people with AVS without treatment develop persistent symptoms, effective treatment of AVS will likely lead to a higher quality of life and help reduce the societal costs associated with dizziness and vertigo.

Trial registration

Clinicaltrials.gov NCT05056324. Registered on September 24, 2021.
Literature
1.
go back to reference Kerber KA, Meurer WJ, West BT, Fendrick AM. Dizziness presentations in U.S. emergency departments, 1995-2004. Acad Emerg Med. 2008;15(8):744–50.CrossRef Kerber KA, Meurer WJ, West BT, Fendrick AM. Dizziness presentations in U.S. emergency departments, 1995-2004. Acad Emerg Med. 2008;15(8):744–50.CrossRef
2.
go back to reference Newman-Toker DE, Hsieh YH, Camargo CA Jr, Pelletier AJ, Butchy GT, Edlow JA. Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. Mayo Clin Proc. 2008;83(7):765–75.CrossRef Newman-Toker DE, Hsieh YH, Camargo CA Jr, Pelletier AJ, Butchy GT, Edlow JA. Spectrum of dizziness visits to US emergency departments: cross-sectional analysis from a nationally representative sample. Mayo Clin Proc. 2008;83(7):765–75.CrossRef
3.
go back to reference Kroenke K, Hoffman RM, Einstadter D. How common are various causes of dizziness? A critical review. South Med J. 2000;93(2):160–7 quiz 8.PubMed Kroenke K, Hoffman RM, Einstadter D. How common are various causes of dizziness? A critical review. South Med J. 2000;93(2):160–7 quiz 8.PubMed
4.
go back to reference Royl G, Ploner CJ, Leithner C. Dizziness in the emergency room: diagnoses and misdiagnoses. Eur Neurol. 2011;66(5):256–63.CrossRef Royl G, Ploner CJ, Leithner C. Dizziness in the emergency room: diagnoses and misdiagnoses. Eur Neurol. 2011;66(5):256–63.CrossRef
5.
go back to reference Ljunggren M, Persson J, Salzer J. Dizziness and the acute vestibular syndrome at the emergency department: a population-based descriptive study. Eur Neurol. 2018;79(1-2):5–12.CrossRef Ljunggren M, Persson J, Salzer J. Dizziness and the acute vestibular syndrome at the emergency department: a population-based descriptive study. Eur Neurol. 2018;79(1-2):5–12.CrossRef
6.
go back to reference Kerber KA, Callaghan BC, Telian SA, Meurer WJ, Skolarus LE, Carender W, et al. Dizziness symptom type prevalence and overlap: a US nationally representative survey. Am J Med. 2017;130(12):1465.e1–9.CrossRef Kerber KA, Callaghan BC, Telian SA, Meurer WJ, Skolarus LE, Carender W, et al. Dizziness symptom type prevalence and overlap: a US nationally representative survey. Am J Med. 2017;130(12):1465.e1–9.CrossRef
7.
go back to reference Friberg E, Jansson C, Mittendorfer-Rutz E, Rosenhall U, Alexanderson K. Sickness absence due to otoaudiological diagnoses and risk of disability pension: a nationwide Swedish prospective cohort study. PLoS One. 2012;7(1):e29966.CrossRef Friberg E, Jansson C, Mittendorfer-Rutz E, Rosenhall U, Alexanderson K. Sickness absence due to otoaudiological diagnoses and risk of disability pension: a nationwide Swedish prospective cohort study. PLoS One. 2012;7(1):e29966.CrossRef
8.
go back to reference Friberg E, Rosenhall U, Alexanderson K. Sickness absence due to otoaudiological diagnoses; a descriptive nationwide study. BMC Public Health. 2013;13:635.CrossRef Friberg E, Rosenhall U, Alexanderson K. Sickness absence due to otoaudiological diagnoses; a descriptive nationwide study. BMC Public Health. 2013;13:635.CrossRef
9.
go back to reference Kovacs E, Wang X, Grill E. Economic burden of vertigo: a systematic review. Heal Econ Rev. 2019;9(1):37.CrossRef Kovacs E, Wang X, Grill E. Economic burden of vertigo: a systematic review. Heal Econ Rev. 2019;9(1):37.CrossRef
10.
go back to reference Geraghty AWA, Essery R, Kirby S, Stuart B, Turner D, Little P, et al. Internet-based vestibular rehabilitation for older adults with chronic dizziness: a randomized controlled trial in primary care. Ann Fam Med. 2017;15(3):209–16.CrossRef Geraghty AWA, Essery R, Kirby S, Stuart B, Turner D, Little P, et al. Internet-based vestibular rehabilitation for older adults with chronic dizziness: a randomized controlled trial in primary care. Ann Fam Med. 2017;15(3):209–16.CrossRef
11.
go back to reference Yardley L, Donovan-Hall M, Smith HE, Walsh BM, Mullee M, Bronstein AM. Effectiveness of primary care-based vestibular rehabilitation for chronic dizziness. Ann Intern Med. 2004;141(8):598–605.CrossRef Yardley L, Donovan-Hall M, Smith HE, Walsh BM, Mullee M, Bronstein AM. Effectiveness of primary care-based vestibular rehabilitation for chronic dizziness. Ann Intern Med. 2004;141(8):598–605.CrossRef
12.
go back to reference Tokle G, Morkved S, Brathen G, Goplen FK, Salvesen O, Arnesen H, et al. Efficacy of vestibular rehabilitation following acute vestibular neuritis: a randomized controlled trial. Otol Neurotol. 2020;41(1):78–85.CrossRef Tokle G, Morkved S, Brathen G, Goplen FK, Salvesen O, Arnesen H, et al. Efficacy of vestibular rehabilitation following acute vestibular neuritis: a randomized controlled trial. Otol Neurotol. 2020;41(1):78–85.CrossRef
13.
go back to reference van Vugt VA, van der Wouden JC, Essery R, Yardley L, Twisk JWR, van der Horst HE, et al. Internet based vestibular rehabilitation with and without physiotherapy support for adults aged 50 and older with a chronic vestibular syndrome in general practice: three armed randomised controlled trial. BMJ. 2019;367:l5922.CrossRef van Vugt VA, van der Wouden JC, Essery R, Yardley L, Twisk JWR, van der Horst HE, et al. Internet based vestibular rehabilitation with and without physiotherapy support for adults aged 50 and older with a chronic vestibular syndrome in general practice: three armed randomised controlled trial. BMJ. 2019;367:l5922.CrossRef
14.
go back to reference Heinrichs N, Edler C, Eskens S, Mielczarek MM, Moschner C. Predicting continued dizziness after an acute peripheral vestibular disorder. Psychosom Med. 2007;69(7):700–7.CrossRef Heinrichs N, Edler C, Eskens S, Mielczarek MM, Moschner C. Predicting continued dizziness after an acute peripheral vestibular disorder. Psychosom Med. 2007;69(7):700–7.CrossRef
15.
go back to reference Chan AW, Tetzlaff JM, Gotzsche PC, Altman DG, Mann H, Berlin JA, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013;346:e7586.CrossRef Chan AW, Tetzlaff JM, Gotzsche PC, Altman DG, Mann H, Berlin JA, et al. SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ. 2013;346:e7586.CrossRef
16.
go back to reference Cousins S, Kaski D, Cutfield N, Arshad Q, Ahmad H, Gresty MA, et al. Predictors of clinical recovery from vestibular neuritis: a prospective study. Ann Clin Transl Neurol. 2017;4(5):340–6.CrossRef Cousins S, Kaski D, Cutfield N, Arshad Q, Ahmad H, Gresty MA, et al. Predictors of clinical recovery from vestibular neuritis: a prospective study. Ann Clin Transl Neurol. 2017;4(5):340–6.CrossRef
17.
go back to reference Fishman JM, Burgess C, Waddell A. Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis). Cochrane Database Syst Rev. 2011;(5):CD008607. Fishman JM, Burgess C, Waddell A. Corticosteroids for the treatment of idiopathic acute vestibular dysfunction (vestibular neuritis). Cochrane Database Syst Rev. 2011;(5):CD008607.
19.
go back to reference Wilhelmsen K, Strand LI, Nordahl SHG, Eide GE, Ljunggren AE. Psychometric properties of the vertigo symptom scale - short form. BMC Ear Nose Throat Disord. 2008;8:2.CrossRef Wilhelmsen K, Strand LI, Nordahl SHG, Eide GE, Ljunggren AE. Psychometric properties of the vertigo symptom scale - short form. BMC Ear Nose Throat Disord. 2008;8:2.CrossRef
20.
go back to reference Yanik B, Külcü DG, Kurtais Y, Boynukalin S, Kurtarah H, Gökmen D. The reliability and validity of the vertigo symptom scale and the vertigo dizziness imbalance questionnaires in a Turkish patient population with benign paroxysmal positional vertigo. J Vestib Res. 2008;18(2-3):159–70.CrossRef Yanik B, Külcü DG, Kurtais Y, Boynukalin S, Kurtarah H, Gökmen D. The reliability and validity of the vertigo symptom scale and the vertigo dizziness imbalance questionnaires in a Turkish patient population with benign paroxysmal positional vertigo. J Vestib Res. 2008;18(2-3):159–70.CrossRef
21.
go back to reference Kondo M, Kiyomizu K, Goto F, Kitahara T, Imai T, Hashimoto M, et al. Analysis of vestibular-balance symptoms according to symptom duration: dimensionality of the vertigo symptom scale-short form. Health Qual Life Outcomes. 2015;13:4.CrossRef Kondo M, Kiyomizu K, Goto F, Kitahara T, Imai T, Hashimoto M, et al. Analysis of vestibular-balance symptoms according to symptom duration: dimensionality of the vertigo symptom scale-short form. Health Qual Life Outcomes. 2015;13:4.CrossRef
22.
go back to reference Jacobson GP, Newman CW. The development of the dizziness handicap inventory. Arch Otolaryngol Head Neck Surg. 1990;116(4):424–7.CrossRef Jacobson GP, Newman CW. The development of the dizziness handicap inventory. Arch Otolaryngol Head Neck Surg. 1990;116(4):424–7.CrossRef
23.
go back to reference Jarlsäter S, Mattsson E. Test of reliability of the dizziness handicap inventory and the activities-specific balance confidence scale for use in Sweden. Adv Physiother. 2003;5(3):137–44.CrossRef Jarlsäter S, Mattsson E. Test of reliability of the dizziness handicap inventory and the activities-specific balance confidence scale for use in Sweden. Adv Physiother. 2003;5(3):137–44.CrossRef
25.
go back to reference Burstrom K, Sun S, Gerdtham UG, Henriksson M, Johannesson M, Levin LA, et al. Swedish experience-based value sets for EQ-5D health states. Qual Life Res. 2014;23(2):431–42.CrossRef Burstrom K, Sun S, Gerdtham UG, Henriksson M, Johannesson M, Levin LA, et al. Swedish experience-based value sets for EQ-5D health states. Qual Life Res. 2014;23(2):431–42.CrossRef
26.
go back to reference Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997;35(11):1095–108.CrossRef Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997;35(11):1095–108.CrossRef
27.
go back to reference Kim SC, Kim JY, Lee HN, Lee HH, Kwon JH, Kim NB, et al. A quantitative analysis of gait patterns in vestibular neuritis patients using gyroscope sensor and a continuous walking protocol. J Neuroeng Rehabil. 2014;11:58.CrossRef Kim SC, Kim JY, Lee HN, Lee HH, Kwon JH, Kim NB, et al. A quantitative analysis of gait patterns in vestibular neuritis patients using gyroscope sensor and a continuous walking protocol. J Neuroeng Rehabil. 2014;11:58.CrossRef
28.
go back to reference Grip H, Nilsson KG, Hager CK, Lundstrom R, Ohberg F. Does the femoral head size in hip Arthroplasty influence lower body movements during squats, gait and stair walking? A clinical pilot study based on wearable motion sensors. Sensors 2019;19(14):3240. Grip H, Nilsson KG, Hager CK, Lundstrom R, Ohberg F. Does the femoral head size in hip Arthroplasty influence lower body movements during squats, gait and stair walking? A clinical pilot study based on wearable motion sensors. Sensors 2019;19(14):3240.
29.
go back to reference Ahmadi SA, Vivar G, Frei J, Nowoshilow S, Bardins S, Brandt T, et al. Towards computerized diagnosis of neurological stance disorders: data mining and machine learning of posturography and sway. J Neurol. 2019;266(Suppl 1):108–17.CrossRef Ahmadi SA, Vivar G, Frei J, Nowoshilow S, Bardins S, Brandt T, et al. Towards computerized diagnosis of neurological stance disorders: data mining and machine learning of posturography and sway. J Neurol. 2019;266(Suppl 1):108–17.CrossRef
30.
go back to reference Sandlund MG, Diamant A, Granasen G, Salzer J. Effectiveness of care in acute dizziness presentations. Eur Arch Otorhinolaryngol. 2019;276(9):2389–96.CrossRef Sandlund MG, Diamant A, Granasen G, Salzer J. Effectiveness of care in acute dizziness presentations. Eur Arch Otorhinolaryngol. 2019;276(9):2389–96.CrossRef
31.
go back to reference Navari E, Cerchiai N, Casani AP. Assessment of Vestibulo-ocular reflex gain and catch-up saccades during vestibular rehabilitation. Otol Neurotol. 2018;39(10):e1111–e7.CrossRef Navari E, Cerchiai N, Casani AP. Assessment of Vestibulo-ocular reflex gain and catch-up saccades during vestibular rehabilitation. Otol Neurotol. 2018;39(10):e1111–e7.CrossRef
Metadata
Title
Internet-based vestibular rehabilitation versus standard care after acute onset vertigo: a study protocol for a randomized controlled trial
Authors
Solmaz Surano
Helena Grip
Fredrik Öhberg
Marcus Karlsson
Erik Faergemann
Maria Bjurman
Hugo Davidsson
Torbjörn Ledin
Ellen Lindell
Jan Mathé
Fredrik Tjernström
Tatjana Tomanovic
Gabriel Granåsen
Jonatan Salzer
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Trials / Issue 1/2022
Electronic ISSN: 1745-6215
DOI
https://doi.org/10.1186/s13063-022-06460-0

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