Skip to main content
Top
Published in: Lasers in Medical Science 4/2015

01-05-2015 | Review Article

Benefits of laser phototherapy on nerve repair

Authors: Renata Ferreira de Oliveira, Daniela Miranda Richarte de Andrade Salgado, Lívia Tosi Trevelin, Raquel Marianna Lopes, Sandra Ribeiro Barros da Cunha, Ana Cecília Correa Aranha, Carlos de Paula Eduardo, Patricia Moreira de Freitas

Published in: Lasers in Medical Science | Issue 4/2015

Login to get access

Abstract

Post-traumatic nerve repair represents a major challenge to health sciences. Although there have been great advances in the last few years, it is still necessary to find methods that can effectively enhance nerve regeneration. Laser therapy has been widely investigated as a potential method for nerve repair. Therefore, in this article, a review of the existing literature was undertaken with regard to the effects of low-power laser irradiation on the regeneration of traumatically/surgically injured nerves. The articles were selected using either electronic search engines or manual tracing of the references cited in key papers. In electronic searches, we used the key words as “paresthesia”, “laser therapy”, “low-power laser and nerve repair”, and “laser therapy and nerve repair”, considering case reports and clinical studies. According to the findings of the literature, laser therapy accelerates and improves the regeneration of the affected nerve tissues, but there are many conflicting results about laser therapy. This can be attributed to several variables such as wavelength, radiation dose, and type of radiation. All the early in vivo studies assessed in this research were effective in restoring sensitivity. Although these results indicate a potential benefit of the use of lasers on nerve repair, further double-blind controlled clinical trials should be conducted in order to standardize protocols for clinical application.
Literature
1.
go back to reference Hillerup S, Jensen R (2006) Nerve injury caused by mandibular block analgesia. Int J Oral Maxillofac Surg 35:437–443PubMed Hillerup S, Jensen R (2006) Nerve injury caused by mandibular block analgesia. Int J Oral Maxillofac Surg 35:437–443PubMed
2.
go back to reference Kunkel M, Kleis W, Morbach T, Wagner W (2007) Severe Third Molar complications including death—lessons from 100 cases requiring hospitalization. J Oral Maxillofac Surg 65:1700–1706PubMed Kunkel M, Kleis W, Morbach T, Wagner W (2007) Severe Third Molar complications including death—lessons from 100 cases requiring hospitalization. J Oral Maxillofac Surg 65:1700–1706PubMed
3.
go back to reference Loescher AR, Smith KG, Robinson PP (2003) Nerve damage and third molar removal. Dent Updat 30:375–380 Loescher AR, Smith KG, Robinson PP (2003) Nerve damage and third molar removal. Dent Updat 30:375–380
4.
go back to reference Rosa FM, Escobar CAB, Brusco LC (2007) Parestesia dos nervos alveolar inferior e lingual pós cirurgia de terceiros molares. RGO 55(3):291–295 Rosa FM, Escobar CAB, Brusco LC (2007) Parestesia dos nervos alveolar inferior e lingual pós cirurgia de terceiros molares. RGO 55(3):291–295
5.
go back to reference Gulicher D, Gerlach KL (2001) Sensory impairment of the lingual and inferior alveolar nerves following removal of impacted mandibular third molars. Int J Oral Maxillofac Surg 30:306PubMed Gulicher D, Gerlach KL (2001) Sensory impairment of the lingual and inferior alveolar nerves following removal of impacted mandibular third molars. Int J Oral Maxillofac Surg 30:306PubMed
6.
go back to reference Giuliani M, Lajolo C, Deli G et al (2001) Inferior alveolar paresthesia caused by endodontic pathosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:670PubMed Giuliani M, Lajolo C, Deli G et al (2001) Inferior alveolar paresthesia caused by endodontic pathosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 92:670PubMed
7.
go back to reference Norifumi N, Takeshi M, Yoshinori H et al (2001) Growth characteristics of ameloblastoma involving the inferior alveolar nerve: a clinical and histopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:557 Norifumi N, Takeshi M, Yoshinori H et al (2001) Growth characteristics of ameloblastoma involving the inferior alveolar nerve: a clinical and histopathologic study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91:557
8.
go back to reference Pogrel MA (2002) The results of microneurosurgery of the inferior alveolar and lingual nerve. J Oral Maxillofac Surg 60:485PubMed Pogrel MA (2002) The results of microneurosurgery of the inferior alveolar and lingual nerve. J Oral Maxillofac Surg 60:485PubMed
9.
go back to reference Chaushu G, Taicher S, Halamish-Shani T et al (2002) Medicolegal aspects of altered sensation following implant placement in the mandible. Int J Oral Maxillofac Implants 17:413PubMed Chaushu G, Taicher S, Halamish-Shani T et al (2002) Medicolegal aspects of altered sensation following implant placement in the mandible. Int J Oral Maxillofac Implants 17:413PubMed
10.
go back to reference Libersa P, Savignat M, Tonnel A (2007) Neurosensory disturbances of the inferior alveolar nerve: a retrospective study of complaints in a 10-year period. J Oral Maxillofac Surg 65:1486–1489PubMed Libersa P, Savignat M, Tonnel A (2007) Neurosensory disturbances of the inferior alveolar nerve: a retrospective study of complaints in a 10-year period. J Oral Maxillofac Surg 65:1486–1489PubMed
11.
go back to reference Ka L, Hirata H, Kobayashi A, Wake H, Kino K, Amagasa T (2005) Treatments results of acupuncture in inferior alveolar and lingual nerves sensory paralysis after oral surgery. J Stomatol 73(1):40–46 Ka L, Hirata H, Kobayashi A, Wake H, Kino K, Amagasa T (2005) Treatments results of acupuncture in inferior alveolar and lingual nerves sensory paralysis after oral surgery. J Stomatol 73(1):40–46
12.
go back to reference Jun H, Cuiping Z, Shunhai C, Shengmin Y (1995) Electric acupuncture treatment of peripheral nerve injury. J Tradit Chin Med 15(2):114–117 Jun H, Cuiping Z, Shunhai C, Shengmin Y (1995) Electric acupuncture treatment of peripheral nerve injury. J Tradit Chin Med 15(2):114–117
14.
go back to reference Rochkind S, Barrnea L, Razon N, Bartal A, Schwartz M (1987) Stimulatory effect of He-Ne low dose on injured sciatic nerves of rats. Neurosurgery 20:843–847PubMed Rochkind S, Barrnea L, Razon N, Bartal A, Schwartz M (1987) Stimulatory effect of He-Ne low dose on injured sciatic nerves of rats. Neurosurgery 20:843–847PubMed
15.
go back to reference Anders JJ, Borke RC, Woolery SK, Van de Merwe WP (1993) Low power laser irradiation alters the rate of regeneration of the rat facial nerve. Lasers Surg Med 13(1):72–82PubMed Anders JJ, Borke RC, Woolery SK, Van de Merwe WP (1993) Low power laser irradiation alters the rate of regeneration of the rat facial nerve. Lasers Surg Med 13(1):72–82PubMed
16.
go back to reference Bisht D, Gupta SC, Mistra V, Mital VP, Sharma P (1994) Effect of low intensity laser irradiation on healing of open skin wounds in rats. Indian J Med Res 100(7):43–46PubMed Bisht D, Gupta SC, Mistra V, Mital VP, Sharma P (1994) Effect of low intensity laser irradiation on healing of open skin wounds in rats. Indian J Med Res 100(7):43–46PubMed
17.
go back to reference Efendiev AI, Tolstykh PI, Dadashev AI, Azimov SA (1992) Increasing the scar strength after preventive skin irradiation with low-intensity laser. Klin Khir 1:23–25PubMed Efendiev AI, Tolstykh PI, Dadashev AI, Azimov SA (1992) Increasing the scar strength after preventive skin irradiation with low-intensity laser. Klin Khir 1:23–25PubMed
18.
go back to reference Hawkins DH, Abrahamse H (2006) The role os laser fluence in cell viability, proliferation, and membrane integrity of wounded human skin fibroblasts following helium-neon laser irradiation. Lasers Surg Med 38(1):74–83PubMed Hawkins DH, Abrahamse H (2006) The role os laser fluence in cell viability, proliferation, and membrane integrity of wounded human skin fibroblasts following helium-neon laser irradiation. Lasers Surg Med 38(1):74–83PubMed
19.
go back to reference Loevschall H, Arenholt-Bindslev D (1994) Effect of low level diode laser irradiation of human oral mucosa fibroblasts in vitro. Lasers Surg Med 14(4):347–354PubMed Loevschall H, Arenholt-Bindslev D (1994) Effect of low level diode laser irradiation of human oral mucosa fibroblasts in vitro. Lasers Surg Med 14(4):347–354PubMed
20.
go back to reference Yu W, Naim JO, Lanzafame RJ (1994) The effect of laser irradiation on the release of bFGF from 3T3 fibroblasts. Photochem Photobiol 59(2):167–170PubMed Yu W, Naim JO, Lanzafame RJ (1994) The effect of laser irradiation on the release of bFGF from 3T3 fibroblasts. Photochem Photobiol 59(2):167–170PubMed
21.
go back to reference Passarella S, Ostuni A, Atlante A, Quagliariello E (1988) Increase in the ADP/ATP exchange in rat liver mitochondria irradiated in vitro by helium-neon laser. Biochem Biophys Res Commum 156(2):978–986 Passarella S, Ostuni A, Atlante A, Quagliariello E (1988) Increase in the ADP/ATP exchange in rat liver mitochondria irradiated in vitro by helium-neon laser. Biochem Biophys Res Commum 156(2):978–986
22.
go back to reference Stadler I, Evans R, Kolb B, Naim JO, Narayan V, Buehner N, Lanzafame RJ (2000) In vivo effects of low-level laser irradiation at 660nm on peripheral blood lymphocytes. Lasers Surg Med 27(3):255–261PubMed Stadler I, Evans R, Kolb B, Naim JO, Narayan V, Buehner N, Lanzafame RJ (2000) In vivo effects of low-level laser irradiation at 660nm on peripheral blood lymphocytes. Lasers Surg Med 27(3):255–261PubMed
23.
go back to reference Agaiby AD, Ghali LR, Wilson R, Dyson M (2000) Laser modulation of angiogenic factor production by T-lymphocytes. Lasers Surg Med 26(4):357–363PubMed Agaiby AD, Ghali LR, Wilson R, Dyson M (2000) Laser modulation of angiogenic factor production by T-lymphocytes. Lasers Surg Med 26(4):357–363PubMed
24.
go back to reference Moore P, Ridgway TD, Higbee RG, Howard EW, Lucroy MD (2005) Effect of wavelength on low-intensity laser irradiation-stimulated cell proliferation in vitro. Lasers Surg Med 36(1):8–12PubMed Moore P, Ridgway TD, Higbee RG, Howard EW, Lucroy MD (2005) Effect of wavelength on low-intensity laser irradiation-stimulated cell proliferation in vitro. Lasers Surg Med 36(1):8–12PubMed
25.
go back to reference Marques MM, Pereira AN, Fujihara NA, Nogueira FN, Eduardo CP (2004) Effect of low-power laser irradiation on protein synthesis and ultrastructure of human gingival fibroblasts. Lasers Surg Med 34(3):260–265PubMed Marques MM, Pereira AN, Fujihara NA, Nogueira FN, Eduardo CP (2004) Effect of low-power laser irradiation on protein synthesis and ultrastructure of human gingival fibroblasts. Lasers Surg Med 34(3):260–265PubMed
26.
go back to reference Mester AF, Snow JB Jr, Shaman P (1991) Photochemical effects of laser irradiation on neuritic outgrowth of olfactory neuroepithelial explants. Otolaryngol Head Neck Surg 105(3):449–456PubMed Mester AF, Snow JB Jr, Shaman P (1991) Photochemical effects of laser irradiation on neuritic outgrowth of olfactory neuroepithelial explants. Otolaryngol Head Neck Surg 105(3):449–456PubMed
27.
go back to reference Rochkind S, Nissan M, Razon N, Schwartz M, Bartal A (1986) Electrophysiological effect of HeNe laser on normal and injured sciatic nerve in the rat. Acta Neurochir 83:125–130PubMed Rochkind S, Nissan M, Razon N, Schwartz M, Bartal A (1986) Electrophysiological effect of HeNe laser on normal and injured sciatic nerve in the rat. Acta Neurochir 83:125–130PubMed
28.
go back to reference Rochkind S, Nissan M, Barr-Nea L, Razon N, Schwartz M, Bartal A (1987) Response of peripheral nerve to He-Ne laser: experimental studies. Lasers Surg Med 7:441–443PubMed Rochkind S, Nissan M, Barr-Nea L, Razon N, Schwartz M, Bartal A (1987) Response of peripheral nerve to He-Ne laser: experimental studies. Lasers Surg Med 7:441–443PubMed
29.
go back to reference Rochkind S, Ouaknine GE (1992) New trend in neuroscience: low power laser effect on peripheral and central nervous system. Neurol Res 14:2–11PubMed Rochkind S, Ouaknine GE (1992) New trend in neuroscience: low power laser effect on peripheral and central nervous system. Neurol Res 14:2–11PubMed
30.
go back to reference Gigo-Benato D, Geuna S, Rochkind S (2005) Phototherapy for enhancing peripheral nerve repair: a review of the literature. Muscle Nerve 31:694–701PubMed Gigo-Benato D, Geuna S, Rochkind S (2005) Phototherapy for enhancing peripheral nerve repair: a review of the literature. Muscle Nerve 31:694–701PubMed
31.
go back to reference Câmara CNS, Brito MVH, Silveira EL, Silva DSG, Simões VRF, Pontes RWF (2011) Histological analysis of low-intensity laser therapy effects in peripheral nerve regeneration in Wistar rats. Acta Cir Bras 26(1):12–18PubMed Câmara CNS, Brito MVH, Silveira EL, Silva DSG, Simões VRF, Pontes RWF (2011) Histological analysis of low-intensity laser therapy effects in peripheral nerve regeneration in Wistar rats. Acta Cir Bras 26(1):12–18PubMed
32.
go back to reference Medalha CC, Di Gangi GC, Barbosa CB, Fernandes M, Aguiar O, Faloppa F, Leite VM, Renno ACM (2012) Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats. Lasers Med Sci 27:629–635. doi:10.1007/s10103-011-1008-9 PubMed Medalha CC, Di Gangi GC, Barbosa CB, Fernandes M, Aguiar O, Faloppa F, Leite VM, Renno ACM (2012) Low-level laser therapy improves repair following complete resection of the sciatic nerve in rats. Lasers Med Sci 27:629–635. doi:10.​1007/​s10103-011-1008-9 PubMed
33.
go back to reference Zhang LX, Tong XJ, Yuan XH, Sun XH, Jia H (2010) Effects of 660-nm gallium–aluminum–arsenide low-energy laser on nerve regeneration after acellular nerve allograft in rats. Synapse 64:152–160PubMed Zhang LX, Tong XJ, Yuan XH, Sun XH, Jia H (2010) Effects of 660-nm gallium–aluminum–arsenide low-energy laser on nerve regeneration after acellular nerve allograft in rats. Synapse 64:152–160PubMed
34.
go back to reference Mester E, Mester AF, Mester A (1985) The biomedical effects of laser application. Lasers Surg Med 5(1):31–39PubMed Mester E, Mester AF, Mester A (1985) The biomedical effects of laser application. Lasers Surg Med 5(1):31–39PubMed
35.
go back to reference Olson JE, Schimmerling W, Tobias CA (1981) Laser action spectrum of reduced excitability in nerve cells. Brain Res 204(2):436–440PubMed Olson JE, Schimmerling W, Tobias CA (1981) Laser action spectrum of reduced excitability in nerve cells. Brain Res 204(2):436–440PubMed
36.
go back to reference Pereira AN, Eduardo Cde P, Matson E, Marques MM (2002) Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med 31(4):263–267PubMed Pereira AN, Eduardo Cde P, Matson E, Marques MM (2002) Effect of low-power laser irradiation on cell growth and procollagen synthesis of cultured fibroblasts. Lasers Surg Med 31(4):263–267PubMed
37.
go back to reference Polo L, Presti F, Schindl A, Schindl L, Jori G, Bertoloni G (1999) Role of ground and excited singlet state oxygen in the red light-induced stimulation of Escherichia coli cell growth. Biochem Biophys Res Commum 257(3):753–758 Polo L, Presti F, Schindl A, Schindl L, Jori G, Bertoloni G (1999) Role of ground and excited singlet state oxygen in the red light-induced stimulation of Escherichia coli cell growth. Biochem Biophys Res Commum 257(3):753–758
38.
go back to reference Sawasaki I, Geraldo-Martins VR, Ribeiro MS, Marques MM (2007) Effect of low-intensity laser therapy on mast cell degranulation in human oral mucosa. Lasers Med Sci 15(12) Sawasaki I, Geraldo-Martins VR, Ribeiro MS, Marques MM (2007) Effect of low-intensity laser therapy on mast cell degranulation in human oral mucosa. Lasers Med Sci 15(12)
39.
go back to reference Schindl A, Schindl M, Pernerstorfer-Schon H, Schindl L (2000) Low-intensity laser therapy: a review. J Investig Med 48(5):312–326PubMed Schindl A, Schindl M, Pernerstorfer-Schon H, Schindl L (2000) Low-intensity laser therapy: a review. J Investig Med 48(5):312–326PubMed
40.
go back to reference Anders JJ, Geuna S, Rochkind S (2004) Phototherapy promotes regeneration and functional recovery of injured peripheral nerve. Neurol Res 26:233–239PubMed Anders JJ, Geuna S, Rochkind S (2004) Phototherapy promotes regeneration and functional recovery of injured peripheral nerve. Neurol Res 26:233–239PubMed
41.
go back to reference Yazdani SO, Golestaneh AF, Shafiee A, Hafizi M, Omrani HAG, Soleimani M (2012) Effects of low level laser therapy on proliferation and neurotrophic factor gene expression of human Schwann cells in vitro. J Photoch Photobiol B 107:9–13 Yazdani SO, Golestaneh AF, Shafiee A, Hafizi M, Omrani HAG, Soleimani M (2012) Effects of low level laser therapy on proliferation and neurotrophic factor gene expression of human Schwann cells in vitro. J Photoch Photobiol B 107:9–13
42.
go back to reference López MC, Galdames IS, Matamala DZ (2008) Effect of low level laser on the perineural thickness of the inferior alveolar nerve. Int J Odontostomat 2(2):123–127 López MC, Galdames IS, Matamala DZ (2008) Effect of low level laser on the perineural thickness of the inferior alveolar nerve. Int J Odontostomat 2(2):123–127
43.
go back to reference Seddon HJ (1942) A classification of nerve injuries. Br Medical J Lond 237–239 Seddon HJ (1942) A classification of nerve injuries. Br Medical J Lond 237–239
44.
go back to reference Sunderland S (1951) A classification of peripheral nerve injuries producing loss of function. Brain 74:491–516PubMed Sunderland S (1951) A classification of peripheral nerve injuries producing loss of function. Brain 74:491–516PubMed
45.
go back to reference Osborn TP, Frederickson G, Small IA, Torgeson TS (1985) A prospective study of complications related to mandibular horizontal osteotomy. Oral Maxillofac Surg 43:767–769 Osborn TP, Frederickson G, Small IA, Torgeson TS (1985) A prospective study of complications related to mandibular horizontal osteotomy. Oral Maxillofac Surg 43:767–769
46.
go back to reference Pogrel MA, Thamby S (2000) Permanent nerve involvement resulting from inferior alveolar nerve blocks. JADA 131(7):901–907PubMed Pogrel MA, Thamby S (2000) Permanent nerve involvement resulting from inferior alveolar nerve blocks. JADA 131(7):901–907PubMed
47.
go back to reference Susarla SM, Kaban LD, Donoff RB, Dodson TB (2007) Funcional sensory recovery after trigeminal nerve repair. J Oral Maxillofac Surg 65(1):60–65PubMed Susarla SM, Kaban LD, Donoff RB, Dodson TB (2007) Funcional sensory recovery after trigeminal nerve repair. J Oral Maxillofac Surg 65(1):60–65PubMed
48.
go back to reference Schulze-Mosgau S, Reich RH (1993) Assessment of inferior alveolar and lingual nerve disturbances after dentoalveolar surgery, and of recovery of sensitivity. J Oral Maxillofac Surg 22:214–217 Schulze-Mosgau S, Reich RH (1993) Assessment of inferior alveolar and lingual nerve disturbances after dentoalveolar surgery, and of recovery of sensitivity. J Oral Maxillofac Surg 22:214–217
49.
go back to reference Lundborg G (2000) A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance. J Hand Surg [Am] 25:391–414 Lundborg G (2000) A 25-year perspective of peripheral nerve surgery: evolving neuroscientific concepts and clinical significance. J Hand Surg [Am] 25:391–414
50.
go back to reference Lundborg G (2002) Enhancing posttraumatic nerve regeneration. J Peripher Nerv Syst 7:139–140PubMed Lundborg G (2002) Enhancing posttraumatic nerve regeneration. J Peripher Nerv Syst 7:139–140PubMed
51.
go back to reference Adour KK (1982) Current concepts in neurology: diagnosis and management of facial paralysis. N Engl J Med 6(307):348–351 Adour KK (1982) Current concepts in neurology: diagnosis and management of facial paralysis. N Engl J Med 6(307):348–351
52.
go back to reference Borin A, Toledo R. e colbs (2006) Modelo experimental comportamental e histológico da regeneração do nervo facial em ratos. Rev Bras Otorrinolaringol 72(6) Borin A, Toledo R. e colbs (2006) Modelo experimental comportamental e histológico da regeneração do nervo facial em ratos. Rev Bras Otorrinolaringol 72(6)
53.
go back to reference Akal UK, Sayan NB, Aydogan S, Yaman Z (2000) Evaluation of the neurosensory deficiencies of oral and maxillofacial region following surgery. Int J Oral Maxillofac Surg 29:331–336PubMed Akal UK, Sayan NB, Aydogan S, Yaman Z (2000) Evaluation of the neurosensory deficiencies of oral and maxillofacial region following surgery. Int J Oral Maxillofac Surg 29:331–336PubMed
54.
go back to reference Vasconcelos BEC, Silva EDO, Dantas WRM, Barros ES, Monteiro GQM (2001) Paralisia facial periférica traumática. Rev Cir Traumat Buco-Maxilo-Facial 1(2):13–20 Vasconcelos BEC, Silva EDO, Dantas WRM, Barros ES, Monteiro GQM (2001) Paralisia facial periférica traumática. Rev Cir Traumat Buco-Maxilo-Facial 1(2):13–20
55.
go back to reference Machado MF, Guzzatti MM, Búrigo M (2012) The role of physiotherapy in cases of paresthesia: a case report. Implant News 9(1):105–110 Machado MF, Guzzatti MM, Búrigo M (2012) The role of physiotherapy in cases of paresthesia: a case report. Implant News 9(1):105–110
56.
go back to reference Chen X, Li Y, Zheng H, Hu K, Zhang H, Zhao L, Li Y, Liu L, Mang L, Yu SA (2009) Randomized controlled trial of acupuncture and moxibustion to treat Bell’s palsy according to different stages: design and protocol. Contemp Clin Trials 30(4):347–353PubMed Chen X, Li Y, Zheng H, Hu K, Zhang H, Zhao L, Li Y, Liu L, Mang L, Yu SA (2009) Randomized controlled trial of acupuncture and moxibustion to treat Bell’s palsy according to different stages: design and protocol. Contemp Clin Trials 30(4):347–353PubMed
57.
go back to reference Li Y, Li Y, Liu LA, Zhao L, Hu KM, Wu X, Chen XQ, Li GP, Mang LL, Qi QH (2011) Acupuncture and moxibustion for peripheral facial palsy at different stages: multi-central large-sample randomized controlled trial. Zhongguo Zhen Jiu 31(4):289–293PubMed Li Y, Li Y, Liu LA, Zhao L, Hu KM, Wu X, Chen XQ, Li GP, Mang LL, Qi QH (2011) Acupuncture and moxibustion for peripheral facial palsy at different stages: multi-central large-sample randomized controlled trial. Zhongguo Zhen Jiu 31(4):289–293PubMed
58.
go back to reference Basford JR (1995) Low intensity laser therapy: still not an established clinical tool. Lasers Surg Med 16(4):331–342PubMed Basford JR (1995) Low intensity laser therapy: still not an established clinical tool. Lasers Surg Med 16(4):331–342PubMed
59.
go back to reference Midamba ED, Haanaes HR (1993) Low reactive-level 830nm GaAlAs diode laser therapy (LLLT) successful regeneration of peripheral nerves in human. Laser Ther 5:125 Midamba ED, Haanaes HR (1993) Low reactive-level 830nm GaAlAs diode laser therapy (LLLT) successful regeneration of peripheral nerves in human. Laser Ther 5:125
60.
go back to reference Rochkind S (1978) Stimulation effect of laser energy on the regeneration of traumatically injured peripheral nerves. Morphogen Regen 83:25–27 Rochkind S (1978) Stimulation effect of laser energy on the regeneration of traumatically injured peripheral nerves. Morphogen Regen 83:25–27
61.
go back to reference Hamilton GF, Keven Robinson T, Ray RH (1992) The effects of helium-neon laser upon regeneration of the crushed peroneal nerve. J Orthop Sports Phys Ther 15:209–214PubMed Hamilton GF, Keven Robinson T, Ray RH (1992) The effects of helium-neon laser upon regeneration of the crushed peroneal nerve. J Orthop Sports Phys Ther 15:209–214PubMed
62.
go back to reference Mindamba ED, Haanaes HR (1993) Effect of low level laser therapy (LLLT) on inferior alveolar, mental and lingual nerves after traumatic injury in 15 patients. A pilot study. Laser Ther 5:89–94 Mindamba ED, Haanaes HR (1993) Effect of low level laser therapy (LLLT) on inferior alveolar, mental and lingual nerves after traumatic injury in 15 patients. A pilot study. Laser Ther 5:89–94
63.
go back to reference Khullar SM, Brodin P, Messelt EB, Haanes HR (1995) The effects of low level laser treatment on recovery of nerve conduction and motor function after compression injury in the rat sciatic nerve. Eur J Oral Sci 103(5):299–305PubMed Khullar SM, Brodin P, Messelt EB, Haanes HR (1995) The effects of low level laser treatment on recovery of nerve conduction and motor function after compression injury in the rat sciatic nerve. Eur J Oral Sci 103(5):299–305PubMed
64.
go back to reference Khullar SM, Brodin P, Barkvoll P, Haanes HR (1996) Preliminary study of low-level laser for treatment of long-standing sensory aberrations in the inferior alveolar nerve. J Oral Maxillofac Surg 54:2–7PubMed Khullar SM, Brodin P, Barkvoll P, Haanes HR (1996) Preliminary study of low-level laser for treatment of long-standing sensory aberrations in the inferior alveolar nerve. J Oral Maxillofac Surg 54:2–7PubMed
65.
go back to reference Miloro M, Repasky M (2000) Low-level laser effect on neurosensory recovery after sagittal ramus osteotomy. Oral Maxillofac Surg 89(1) Miloro M, Repasky M (2000) Low-level laser effect on neurosensory recovery after sagittal ramus osteotomy. Oral Maxillofac Surg 89(1)
66.
go back to reference Rochkind S, Nissan M, Alon M, Shamir M, Salame K (2001) Effects of laser irradiation on the spinal cord for the regeneration of crushed peripheral nerve in rats. Lasers Surg Med 28:216–219PubMed Rochkind S, Nissan M, Alon M, Shamir M, Salame K (2001) Effects of laser irradiation on the spinal cord for the regeneration of crushed peripheral nerve in rats. Lasers Surg Med 28:216–219PubMed
67.
go back to reference Ladalardo PGCCT, Júnior BA, Pinheiro BLA, Takamoto M, Campos CAR (2001) Low level laser therapy in treatment of neurosensory deficit following surgical procedures. Lasers Dent 7:4249 Ladalardo PGCCT, Júnior BA, Pinheiro BLA, Takamoto M, Campos CAR (2001) Low level laser therapy in treatment of neurosensory deficit following surgical procedures. Lasers Dent 7:4249
68.
go back to reference Shamir HM, Rochkind S, Sandbank J, Alon M (2001) Double-blind randomized study evaluating regeneration of the rat transected sciatic nerve after suturing and postoperative low-power laser treatment. J Reconstr Microsurg 17(2) Shamir HM, Rochkind S, Sandbank J, Alon M (2001) Double-blind randomized study evaluating regeneration of the rat transected sciatic nerve after suturing and postoperative low-power laser treatment. J Reconstr Microsurg 17(2)
69.
go back to reference Miloro M, Halkias EL, Mallery S, Travers S, Rashid GR (2002) Low-level laser effect on neural regeneration in Gore-Tex tubes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:27–34. doi:10.1067/moe.2002.119518 PubMed Miloro M, Halkias EL, Mallery S, Travers S, Rashid GR (2002) Low-level laser effect on neural regeneration in Gore-Tex tubes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 93:27–34. doi:10.​1067/​moe.​2002.​119518 PubMed
70.
go back to reference Shin HD, Lee E, Hyun KJ, Lee JS, Chang PY, Kim WJ, Choi SY, Kwon SB (2003) Growth-associated protein-43 is elevated in the injured rat sciatic nerve after low power laser irradiation. Neurosci Lett 344:71–74. doi:10.1016/S0304-3940(03)00354-9 PubMed Shin HD, Lee E, Hyun KJ, Lee JS, Chang PY, Kim WJ, Choi SY, Kwon SB (2003) Growth-associated protein-43 is elevated in the injured rat sciatic nerve after low power laser irradiation. Neurosci Lett 344:71–74. doi:10.​1016/​S0304-3940(03)00354-9 PubMed
71.
go back to reference Gigo-Benato D, Geuna S, Rodrigues AC, Tos P, Fornaro M, Boux E, Battiston B, Giacobini-Robecchi MG (2004) Low-power laser biostimulation enhances nerve repair after end-to-side neurorrhaphy: a double-blind randomized study in the rat median nerve model. Lasers Med Sci 19:57–65PubMed Gigo-Benato D, Geuna S, Rodrigues AC, Tos P, Fornaro M, Boux E, Battiston B, Giacobini-Robecchi MG (2004) Low-power laser biostimulation enhances nerve repair after end-to-side neurorrhaphy: a double-blind randomized study in the rat median nerve model. Lasers Med Sci 19:57–65PubMed
72.
go back to reference Ozen T, Orhan K, Gorur I, Ozturk A (2006) Efficacy of low level laser therapy on neurosensory recovery after injury to the inferior alveolar nerve. Head Face Med 2(3) Ozen T, Orhan K, Gorur I, Ozturk A (2006) Efficacy of low level laser therapy on neurosensory recovery after injury to the inferior alveolar nerve. Head Face Med 2(3)
73.
go back to reference Mohammed IF, Al-Mustawfi N, Kaka LN (2007) Promotion of regenerative processes in injured peripheral nerve induced by low-level laser therapy. Photomed Laser Surg 25(2):107–111PubMed Mohammed IF, Al-Mustawfi N, Kaka LN (2007) Promotion of regenerative processes in injured peripheral nerve induced by low-level laser therapy. Photomed Laser Surg 25(2):107–111PubMed
74.
go back to reference Rochkind S, Leider-Trejo L, Nissan M, Shamir MH, Kharenko O, Alon M (2007) Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study). Photomed Laser Surg 25(3):137–143PubMed Rochkind S, Leider-Trejo L, Nissan M, Shamir MH, Kharenko O, Alon M (2007) Efficacy of 780-nm laser phototherapy on peripheral nerve regeneration after neurotube reconstruction procedure (double-blind randomized study). Photomed Laser Surg 25(3):137–143PubMed
75.
go back to reference Yoshimoto M, Sakita G, Pazos y Garcia MA, Salles MB, Maluf PSZ, Magalhães JCA (2008) Uma nova proposta da reversão da parestesia em lateralização de nervo alveolar inferior. Implant News 5(6):619–625 Yoshimoto M, Sakita G, Pazos y Garcia MA, Salles MB, Maluf PSZ, Magalhães JCA (2008) Uma nova proposta da reversão da parestesia em lateralização de nervo alveolar inferior. Implant News 5(6):619–625
76.
go back to reference Dos Reis FA, Belchior AC, De Carvalho T, Da Silva BA, Pereira DM, Silva IS, Nicolau RA (2009) Effect of laser therapy (660 nm) on recovery of the sciatic nerve in rats after injury through neurotmesis followed by epineural anastomosis. Lasers Med Sci 24(5):741–747PubMed Dos Reis FA, Belchior AC, De Carvalho T, Da Silva BA, Pereira DM, Silva IS, Nicolau RA (2009) Effect of laser therapy (660 nm) on recovery of the sciatic nerve in rats after injury through neurotmesis followed by epineural anastomosis. Lasers Med Sci 24(5):741–747PubMed
77.
go back to reference Belchior ACG, Reis FA, Nicolau RN, Silva IS, Perreira DM, Carvalho PTC (2009) Influence of laser (660nm) on functional recovery of the sciatic nerve in rats following crushing lesion. Lasers Med Sci 24:893–899PubMed Belchior ACG, Reis FA, Nicolau RN, Silva IS, Perreira DM, Carvalho PTC (2009) Influence of laser (660nm) on functional recovery of the sciatic nerve in rats following crushing lesion. Lasers Med Sci 24:893–899PubMed
78.
go back to reference Barbosa RI, Marcolino AM, Guirro RRJ, Mazzer N, Barbieri CH, Fonseca MCR (2010) Comparative effects of wavelengths of low-power laser in regeneration of sciatic nerve in rats following crushing lesion. Lasers Med Sci 25:423–430PubMed Barbosa RI, Marcolino AM, Guirro RRJ, Mazzer N, Barbieri CH, Fonseca MCR (2010) Comparative effects of wavelengths of low-power laser in regeneration of sciatic nerve in rats following crushing lesion. Lasers Med Sci 25:423–430PubMed
79.
go back to reference Gigo-Benato D, Russo TL, Tanaka EK, Assis L, Salvini TF, Parizotto NA (2010) Effects of 660 e 780nm low-level laser therapy on neuromuscular recovery after crush injury in rat sciatic nerve. Lasers Surg Med 42:833–842 Gigo-Benato D, Russo TL, Tanaka EK, Assis L, Salvini TF, Parizotto NA (2010) Effects of 660 e 780nm low-level laser therapy on neuromuscular recovery after crush injury in rat sciatic nerve. Lasers Surg Med 42:833–842
80.
go back to reference Yoshimoto M, Magalhães ACJ, Salles BM, Júnior AS, Zaffalon TG, Suzuki CL, Garcia PAM (2011) Protocolo de regressão de parestesia após cirurgia de lateralização de nervo alveolar inferior. Rev Assoc Paul Cir Dent 65(1):22–26 Yoshimoto M, Magalhães ACJ, Salles BM, Júnior AS, Zaffalon TG, Suzuki CL, Garcia PAM (2011) Protocolo de regressão de parestesia após cirurgia de lateralização de nervo alveolar inferior. Rev Assoc Paul Cir Dent 65(1):22–26
81.
go back to reference Moges H, Wu X, McCoy J, Vasconcelos OM, Bryant H, Grunberg NE, Anders JJ (2011) Effect of 810nm light on nerve regeneration after autograft repair of severely injured rat median nerve. Lasers Surg Med 43:901–906PubMed Moges H, Wu X, McCoy J, Vasconcelos OM, Bryant H, Grunberg NE, Anders JJ (2011) Effect of 810nm light on nerve regeneration after autograft repair of severely injured rat median nerve. Lasers Surg Med 43:901–906PubMed
82.
go back to reference Shen CC, Yang YC, Liu BS (2011) Large-area irradiated low-level laser effect in a biodegradable nerve guide conduit on neural regeneration of peripheral nerve injury in rats. Injury 42(8):803–813PubMed Shen CC, Yang YC, Liu BS (2011) Large-area irradiated low-level laser effect in a biodegradable nerve guide conduit on neural regeneration of peripheral nerve injury in rats. Injury 42(8):803–813PubMed
83.
go back to reference Snyder SK, Byrnes KR, Borke RC, Sanchez A, Anders JJ (2002) Quantification of calcitonin gene-related peptide mRNA and neuronal cell death in facial motor nuclei following axotomy and 633 nm low power laser treatment. Lasers Surg Med 31:216–222PubMed Snyder SK, Byrnes KR, Borke RC, Sanchez A, Anders JJ (2002) Quantification of calcitonin gene-related peptide mRNA and neuronal cell death in facial motor nuclei following axotomy and 633 nm low power laser treatment. Lasers Surg Med 31:216–222PubMed
84.
go back to reference Matsumoto K, Kimura Y (2007) Laser therapy of dentin hypersensitivity. J Oral Laser Appl 7:7–25 Matsumoto K, Kimura Y (2007) Laser therapy of dentin hypersensitivity. J Oral Laser Appl 7:7–25
85.
go back to reference Kimura Y, Wilder-Smith P, Yonaga K, Matsumoto K (2000) Treatment of hypersensitivity by lasers: a review. J Clin Periodontol Oct 27(10):715–721 Kimura Y, Wilder-Smith P, Yonaga K, Matsumoto K (2000) Treatment of hypersensitivity by lasers: a review. J Clin Periodontol Oct 27(10):715–721
86.
go back to reference Karu T (1989) The science of low-power laser effects. Health Phys 56:691–704PubMed Karu T (1989) The science of low-power laser effects. Health Phys 56:691–704PubMed
87.
go back to reference Kahn F, Ritson-Fitz D (1996) Laser heal: chiropractors could benefit from this technology. Dyn Chiropractic 14(18) Kahn F, Ritson-Fitz D (1996) Laser heal: chiropractors could benefit from this technology. Dyn Chiropractic 14(18)
88.
go back to reference Karu T (2010) Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP. Photomed Laser Surg 28:159–160PubMed Karu T (2010) Mitochondrial mechanisms of photobiomodulation in context of new data about multiple roles of ATP. Photomed Laser Surg 28:159–160PubMed
89.
go back to reference Chow R, Arwati P, Laakso L, Bjordal J, Baxter G (2011) Inhibition and releance to analgetic affects: a systematic review. Photomed Laser Surg 29:365–381PubMed Chow R, Arwati P, Laakso L, Bjordal J, Baxter G (2011) Inhibition and releance to analgetic affects: a systematic review. Photomed Laser Surg 29:365–381PubMed
90.
go back to reference Karu T (2013) Is it time to consider photobiomodulation as a drug equivalent? Photomed Laser Surg 31(5) Karu T (2013) Is it time to consider photobiomodulation as a drug equivalent? Photomed Laser Surg 31(5)
91.
go back to reference Raldif V, Niccolli Filho W, DOS Santos LM (2002) Estudo comparativo entre cirurgia convencional e a laser de dióxido de carbono (CO2) na orientação da reparação do nervo facial. Estudo histológico em ratos. Rev Facul Odontol Bauru 10(2):105–111 Raldif V, Niccolli Filho W, DOS Santos LM (2002) Estudo comparativo entre cirurgia convencional e a laser de dióxido de carbono (CO2) na orientação da reparação do nervo facial. Estudo histológico em ratos. Rev Facul Odontol Bauru 10(2):105–111
92.
go back to reference Túner J, Hode L (1998) It’s all in parameters: a critical analysis of some well-known negative studies on low-level laser therapy. J Clin Laser Med Surg 16:245–248PubMed Túner J, Hode L (1998) It’s all in parameters: a critical analysis of some well-known negative studies on low-level laser therapy. J Clin Laser Med Surg 16:245–248PubMed
93.
go back to reference Walsh L (1992) The use of lasers in implantology. J Bras Clin Odontol Int 18:335–340 Walsh L (1992) The use of lasers in implantology. J Bras Clin Odontol Int 18:335–340
94.
go back to reference Passarella S, Casamassima E, Molinari S, Pastore D, Quagliariello E, Catalano IM et al (1984) Increase of próton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium-neon laser. FEBS Lett 175(1):95–99PubMed Passarella S, Casamassima E, Molinari S, Pastore D, Quagliariello E, Catalano IM et al (1984) Increase of próton electrochemical potential and ATP synthesis in rat liver mitochondria irradiated in vitro by helium-neon laser. FEBS Lett 175(1):95–99PubMed
95.
go back to reference Yu W, Naim JO, McGowan M, Ippolito K, Lanzafame RJ (1997) Photomodulation of oxidative metabolism and electron chain enzymes in rat liver mitochondria. Photochem Photobiol 66(6):866–871PubMed Yu W, Naim JO, McGowan M, Ippolito K, Lanzafame RJ (1997) Photomodulation of oxidative metabolism and electron chain enzymes in rat liver mitochondria. Photochem Photobiol 66(6):866–871PubMed
96.
go back to reference Bagis S, Comelekoglu U, Sahin G, Buyukakilli B, Erdogan C, Kanik A (2002) Acute electrophysiologic effect of pulsed galliumarsenide low energy laser irradiation on configuration of compound nerve action potential and nerve excitability. Lasers Surg Med 30:376–380. doi:10.1002/lsm.10057 PubMed Bagis S, Comelekoglu U, Sahin G, Buyukakilli B, Erdogan C, Kanik A (2002) Acute electrophysiologic effect of pulsed galliumarsenide low energy laser irradiation on configuration of compound nerve action potential and nerve excitability. Lasers Surg Med 30:376–380. doi:10.​1002/​lsm.​10057 PubMed
97.
go back to reference Gordon MW (1960) The correlation between in vivo mitochondrial changes and tryptophan pyrrolase activity. Arch Biochem Biophys 91:75–82PubMed Gordon MW (1960) The correlation between in vivo mitochondrial changes and tryptophan pyrrolase activity. Arch Biochem Biophys 91:75–82PubMed
98.
go back to reference Chow RT, David MA, Armati PJ (2007) 830 nm laser irradiation induces varicosity formation, reduces mitochondrial membrane potential and blocks fast axonal flow in small and medium diameter rat dorsal root ganglion neurons: implications for the analgesic effects of 830 nm laser. J Peripher Nerv Syst 12(1):28–39PubMed Chow RT, David MA, Armati PJ (2007) 830 nm laser irradiation induces varicosity formation, reduces mitochondrial membrane potential and blocks fast axonal flow in small and medium diameter rat dorsal root ganglion neurons: implications for the analgesic effects of 830 nm laser. J Peripher Nerv Syst 12(1):28–39PubMed
99.
go back to reference Karu T, Pyatibrat L (2011) Gene expression under laser and light-emitting diodes radiation for modulation of cell adhesion: possible applications for biotechnology. IUBMB Life 63:747–753PubMed Karu T, Pyatibrat L (2011) Gene expression under laser and light-emitting diodes radiation for modulation of cell adhesion: possible applications for biotechnology. IUBMB Life 63:747–753PubMed
100.
go back to reference George EB, Glass JD, Griffin JW (1995) Axotomy-induced axonal degeneration is mediated by calcium influx through ionspecific channels. J Neurosci 15:6445–6452PubMed George EB, Glass JD, Griffin JW (1995) Axotomy-induced axonal degeneration is mediated by calcium influx through ionspecific channels. J Neurosci 15:6445–6452PubMed
101.
go back to reference Schlaepfer WW, Bunge RP (1973) Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture. J Cell Biol 59:456–470PubMedCentralPubMed Schlaepfer WW, Bunge RP (1973) Effects of calcium ion concentration on the degeneration of amputated axons in tissue culture. J Cell Biol 59:456–470PubMedCentralPubMed
102.
go back to reference Hirata K, Kawabuchi M (2002) Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration. Microsc Res Tech 57:541–547PubMed Hirata K, Kawabuchi M (2002) Myelin phagocytosis by macrophages and nonmacrophages during Wallerian degeneration. Microsc Res Tech 57:541–547PubMed
103.
go back to reference Perry VH, Brown MC (1992) Macrophages and nerve regeneration. Curr Opin Neurobiol 2:679–682PubMed Perry VH, Brown MC (1992) Macrophages and nerve regeneration. Curr Opin Neurobiol 2:679–682PubMed
104.
go back to reference Hall S (2001) Nerve repair: a neurobiologist’s view. J Hand Surg 26B:129–136 Hall S (2001) Nerve repair: a neurobiologist’s view. J Hand Surg 26B:129–136
105.
go back to reference Salonen V, Aho H, Röyttä M, Peltonen J (1988) Quantitation of Schwann cells and endoneurial fibroblasts-like cells after experimental nerve trauma. Acta Neuropathol (Berl) 75:331–336 Salonen V, Aho H, Röyttä M, Peltonen J (1988) Quantitation of Schwann cells and endoneurial fibroblasts-like cells after experimental nerve trauma. Acta Neuropathol (Berl) 75:331–336
106.
go back to reference Clemence A, Mirsky R, Jessen KR (1989) Non-myelin-forming Schwann cells proliferate rapidly during Wallerian degeneration in the rat sciatic nerve. J Neurocytol 18:185–192PubMed Clemence A, Mirsky R, Jessen KR (1989) Non-myelin-forming Schwann cells proliferate rapidly during Wallerian degeneration in the rat sciatic nerve. J Neurocytol 18:185–192PubMed
107.
go back to reference Miró L, Coupe M, Charras C, Jambon C, Chevalier JM (1984) Estudio capilosroscópico de la acción de um laser de AsGa sobre la microcirculación. Invest Clin Laser 2(9) Miró L, Coupe M, Charras C, Jambon C, Chevalier JM (1984) Estudio capilosroscópico de la acción de um laser de AsGa sobre la microcirculación. Invest Clin Laser 2(9)
108.
go back to reference Magaewa Y, Itoh T, Hosokawa T, Yaegashi K, Nishi M (2000) Effects of near-infrared low-level laser irradiation on microcirculation. Lasers Surg Med 27(5):427–437 Magaewa Y, Itoh T, Hosokawa T, Yaegashi K, Nishi M (2000) Effects of near-infrared low-level laser irradiation on microcirculation. Lasers Surg Med 27(5):427–437
110.
go back to reference Bagis S, Comelekoglu U, Coskun B, Milcan A, Buyukakilli B, Sahin G et al (2003) No effect of GA-AS (904 nm) laser irradiation on the intact skin of the injured rat sciatic nerve. Lasers Med Sci 18:83–88PubMed Bagis S, Comelekoglu U, Coskun B, Milcan A, Buyukakilli B, Sahin G et al (2003) No effect of GA-AS (904 nm) laser irradiation on the intact skin of the injured rat sciatic nerve. Lasers Med Sci 18:83–88PubMed
111.
go back to reference Chen YS, Hsu SF, Chiu CW, Lin JG, Chen CT, Yao CH (2005) Effect of low-power pulsed laser on peripheral nerve regeneration in rats. Microsurgery 25:83–89PubMed Chen YS, Hsu SF, Chiu CW, Lin JG, Chen CT, Yao CH (2005) Effect of low-power pulsed laser on peripheral nerve regeneration in rats. Microsurgery 25:83–89PubMed
112.
go back to reference Teerijoki-Oksa T, Jääskeläinen S, Forssell K, Virtsnen A, Forssell H (2003) An evaluation of clinical and electrophysiologic tests in nerve injury diagnosis after mandibular sagittal split osteotomy. Int J Oral Maxillofac Surg 32:15–23PubMed Teerijoki-Oksa T, Jääskeläinen S, Forssell K, Virtsnen A, Forssell H (2003) An evaluation of clinical and electrophysiologic tests in nerve injury diagnosis after mandibular sagittal split osteotomy. Int J Oral Maxillofac Surg 32:15–23PubMed
113.
go back to reference Caissie et al (2007) Quantitative method to evaluate the functionality of the trigeminal nerve. J Oral Maxillofac Surg 65:2254–2259PubMed Caissie et al (2007) Quantitative method to evaluate the functionality of the trigeminal nerve. J Oral Maxillofac Surg 65:2254–2259PubMed
114.
go back to reference Lee J et al (2007) Thermographic assessment of inferior alveolar nerve injury in patients with dentofacial deformity. J Oral Maxillofac Surg 65:74–78PubMed Lee J et al (2007) Thermographic assessment of inferior alveolar nerve injury in patients with dentofacial deformity. J Oral Maxillofac Surg 65:74–78PubMed
Metadata
Title
Benefits of laser phototherapy on nerve repair
Authors
Renata Ferreira de Oliveira
Daniela Miranda Richarte de Andrade Salgado
Lívia Tosi Trevelin
Raquel Marianna Lopes
Sandra Ribeiro Barros da Cunha
Ana Cecília Correa Aranha
Carlos de Paula Eduardo
Patricia Moreira de Freitas
Publication date
01-05-2015
Publisher
Springer London
Published in
Lasers in Medical Science / Issue 4/2015
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI
https://doi.org/10.1007/s10103-014-1531-6

Other articles of this Issue 4/2015

Lasers in Medical Science 4/2015 Go to the issue