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01-12-2006 | Review

Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill

Authors: Trung C Nguyen, Joseph A Carcillo

Published in: Critical Care | Issue 6/2006

Abstract

New onset thrombocytopenia and multiple organ failure (TAMOF) presages poor outcome in critical illness. Patients who resolve thrombocytopenia by day 14 are more likely to survive than those who do not. Patients with TAMOF have a spectrum of microangiopathic disorders that includes thrombotic thrombocytopenic purpura (TTP), disseminated intravascular coagulation (DIC) and secondary thrombotic microanigiopathy (TMA). Activated protein C is effective in resolving fibrin-mediated thrombosis (DIC); however, daily plasma exchange is the therapy of choice for removing ADAMTS 13 inhibitors and replenishing ADAMTS 13 activity which in turn resolves platelet: von Willebrand Factor mediated thrombosis (TTP/secondary TMA).

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Title: Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill
Authors: Trung C Nguyen
Joseph A Carcillo
Publication date: 01-12-2006
Publisher: BioMed Central
Published in: Critical Care / Issue 6/2006
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc5064

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Bench-to-bedside review: Thrombocytopenia-associated multiple organ failure – a newly appreciated syndrome in the critically ill

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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