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Systematic Reviews
Published in: Systematic Reviews 1/2019

Open Access 01-12-2019 | Behavioural Therapy | Protocol

Psychological interventions for people with psychotic experiences: protocol for a systematic review and meta-analysis

Authors: Emma Soneson, Debra Russo, Clare Knight, Louise Lafortune, Margaret Heslin, Jan Stochl, Alex Georgiadis, Julieta Galante, Robbie Duschinsky, Nick Grey, Leticia Gonzalez-Blanco, Juliet Couche, Michelle Griffiths, Hannah Murray, Nesta Reeve, Joanne Hodgekins, Paul French, David Fowler, Sarah Byford, Mary Dixon-Woods, Peter B. Jones, Jesus Perez

Published in: Systematic Reviews | Issue 1/2019

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Abstract

Background

Many people who have common mental disorders, such as depression and anxiety, also have some psychotic experiences. These experiences are associated with higher clinical complexity, poor treatment response, and negative clinical outcomes. Psychological interventions have the potential to improve outcomes for people with psychotic experiences. The aims of this systematic review are to (1) synthesise the evidence on the effectiveness and cost-effectiveness of psychological interventions to reduce psychotic experiences and their associated distress and (2) identify key components of effective interventions.

Methods

Our search strategy will combine terms for (1) psychological interventions, (2) psychotic experiences, and (3) symptoms associated with psychotic experiences. We will search the following online databases: MEDLINE, Embase, PsycINFO, all Cochrane databases, British Nursing Index (BNI), Cumulative Index to Nursing and Allied Health Literature (CINAHL), Health Management Information Consortium (HMIC), Education Resources Information Center (ERIC), and EconLit. Our primary outcome is the proportion of people who recovered or remitted from psychotic experiences after the intervention. Our secondary outcomes are changes in positive psychotic symptoms, negative psychotic symptoms, depression, anxiety, functioning (including social, occupational, and academic), quality of life, and cost-effectiveness. Two independent reviewers will judge each study against pre-specified inclusion and exclusion criteria and will extract study characteristics, outcome data, and intervention components. Risk of bias and methodological quality will be assessed using the Effective Public Health Practice Project Quality Assessment Tool for Quantitative Studies and the Drummond Checklist. Results will be synthesised using random-effects meta-analysis and narrative synthesis.

Discussion

The identification of effective psychological interventions and of specific components associated with intervention effectiveness will augment existing evidence that can inform the development of a new, tailored intervention to improve outcomes related to psychotic symptoms, anxiety and depression, distress, functioning, and quality of life.

Systematic review registration

Appendix
Available only for authorised users
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Metadata
Title
Psychological interventions for people with psychotic experiences: protocol for a systematic review and meta-analysis
Authors
Emma Soneson
Debra Russo
Clare Knight
Louise Lafortune
Margaret Heslin
Jan Stochl
Alex Georgiadis
Julieta Galante
Robbie Duschinsky
Nick Grey
Leticia Gonzalez-Blanco
Juliet Couche
Michelle Griffiths
Hannah Murray
Nesta Reeve
Joanne Hodgekins
Paul French
David Fowler
Sarah Byford
Mary Dixon-Woods
Peter B. Jones
Jesus Perez
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Systematic Reviews / Issue 1/2019
Electronic ISSN: 2046-4053
DOI
https://doi.org/10.1186/s13643-019-1041-5

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