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At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
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Annals of Behavioral Medicine
Published in: Annals of Behavioral Medicine 3/2013

01-12-2013 | Original Article

Behavioral Mediators of Treatment Effects in the Weight Loss Maintenance Trial

Authors: J. W. Coughlin, Ph.D., C. M. Gullion, Ph.D., P. J. Brantley, Ph.D., V. J. Stevens, Ph.D., A. Bauck, B.S., C. M. Champagne, Ph.D., A. T. Dalcin, R.D., K. L. Funk, M.S., R.D., J. F. Hollis, Ph.D., G. J. Jerome, Ph.D., L. F. Lien, M.D., C. M. Loria, Ph.D., V. H. Myers, Ph.D., L. J. Appel, M.D.

Published in: Annals of Behavioral Medicine | Issue 3/2013

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Abstract

Background

The Weight Loss Maintenance Trial tested strategies for maintenance of weight loss. Personal contact was superior to interactive technology and self-directed conditions.

Purpose

We aimed to identify behavioral mediators of the superior effect of personal contact vs. interactive technology and of personal contact vs. self-directed arms.

Methods

Overweight/obese adults at risk for cardiovascular disease (n = 1,032) who lost at least 4 kg were randomized to personal contact, interactive technology, or self-directed. After 30 months, 880 participants had data on weight and behavioral strategies.

Results

Reported increase of intake of fruits and vegetables and physical activity and more frequent self-weighing met criteria as mediators of the better outcome of personal contact vs. interactive technology. Increased intake of fruits and vegetables, more frequent self-weighing, and decreased dessert consumption were mediators of the difference between personal contact vs. self-directed.

Conclusion

Inducing changes in the identified behaviors might yield better outcomes in future weight loss maintenance trials.
(ClinicalTrials.gov number NCT00054925)
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Metadata
Title
Behavioral Mediators of Treatment Effects in the Weight Loss Maintenance Trial
Authors
J. W. Coughlin, Ph.D.
C. M. Gullion, Ph.D.
P. J. Brantley, Ph.D.
V. J. Stevens, Ph.D.
A. Bauck, B.S.
C. M. Champagne, Ph.D.
A. T. Dalcin, R.D.
K. L. Funk, M.S., R.D.
J. F. Hollis, Ph.D.
G. J. Jerome, Ph.D.
L. F. Lien, M.D.
C. M. Loria, Ph.D.
V. H. Myers, Ph.D.
L. J. Appel, M.D.
Publication date
01-12-2013
Publisher
Springer US
Published in
Annals of Behavioral Medicine / Issue 3/2013
Print ISSN: 0883-6612
Electronic ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-013-9517-3

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