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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2015

Open Access 01-12-2016 | Review article

Behavioral management of headache in children and adolescents

Authors: Noemi Faedda, Rita Cerutti, Paola Verdecchia, Daniele Migliorini, Marco Arruda, Vincenzo Guidetti

Published in: The Journal of Headache and Pain | Issue 1/2015

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Abstract

Headache is the most frequent neurological symptom and the most prevalent pain in children and adolescents, and constitutes a serious health problem that may lead to impairment in several areas. Psychosocial factors, social environment, life events, school and family stressors are all closely related to headaches. A multidisciplinary strategy is fundamental in addressing headache in children and adolescents. Applying such a strategy can lead to reductions in frequency and severity of the pain, improving significantly the quality of life of these children.
It has been demonstrated that behavioral intervention is highly effective, especially in the treatment of paediatric headache, and can enhance or replace pharmacotherapy, with the advantage of eliminating dangerous side effects and or reducing costs. Behavioral interventions appear to maximize long-term therapeutic benefits and improve compliance with pharmacological treatment, which has proven a significant problem with child and adolescent with headache.
The goal of this review is to examine the existing literature on behavioral therapies used to treat headache in children and adolescents, and so provide an up-to-date picture of what behavioral therapy is and what its effectiveness is.
Literature
1.
Abu-Arafeh I (2014) Diagnosis and management of headache in children and adolescents. Prog Neurol Psychiatry 18(4):16–20CrossRef
2.
3.
4.
Powers SW, Andrasik F (2005) Biobehavioral treatment, disability, and psychological effects of pediatric headache. Pediatr Ann 34:461–465PubMedCrossRef
5.
Bellini B, Arruda M, Cescut A, Saulle C, Persico A, Carotenuto M, Gatta M, Nacinovich R, Piazza FP, Termine C, Tozzi E, Lucchese F, Guidetti V (2013) Headache and comorbidity in children and adolescents. J Headache Pain 14:79PubMedPubMedCentralCrossRef
6.
Blaauw BA, Dyb G, Hagen K, Holmen TL, Linde M, Wentzel-Larsen T, Zwart JA (2015) The relationship of anxiety, depression and behavioral problems with recurrent headache in late adolescence – a Young-HUNT follow-up study. J Headache Pain 16:10PubMedPubMedCentralCrossRef
7.
Pompili M, Serafini G, Di Cosimo D, Dominici G, Innamorati M, Lester D, Forte A, Girardi N, De Filippis S, Tatarelli R, Martelletti P (2010) Psychiatric comorbidity and suicide risk in patients with chronic migraine. Neuropsychiatr Dis Treat 6:81–91PubMedPubMedCentralCrossRef
8.
Serafini G, Pompili M, Innamorati M, Gentile G, Borro M, Lamis DA, Lala N, Negro A, Simmaco M, Girardi P, Martelletti P (2012) Gene variants with suicidal risk in a sample of subjects with chronic migraine and affective temperamental dysregulation. Eur Rev Med Pharmacol Sci 16(10):1389–1398PubMed
9.
Serafini G, Pompili M, Innamorati M, Negro A, Fiorillo M, Lamis DA, Erbuto D, Marsibilio F, Romano A, Amore M, D’Alonzo L, Bozzao A, Girardi P, Martelletti P (2012) White matter hyperintensities and self-reported depression in a sample of patients with chronic headache. J Headache Pain 13(8):661–667PubMedPubMedCentralCrossRef
10.
Piccinini M, Vieno A, Santinello M (2011) Use of medicines and lifestyles among Italian adolescents. Epidemiol Prev 35(3-4):222–228PubMed
11.
Christiansen S, Jürgens TP, Klinger R (2015) Outpatient Combined Group and Individual Cognitive-Behavioral Treatment for Patients With Migraine and Tension-Type Headache in a Routine Clinical Setting. Headache 55(8):1072–1091PubMedCrossRef
12.
Powers SW, Kashikar-Zuck SM, Allen JR, LeCates SL, Slater SK, Zafar M, Kabbouche MA, O’Brien HL, Shenk CE, Rausch JR, Hershey AD (2013) Cognitive Behavioral Therapy Plus Amitriptyline for Chronic Migraine in Children and Adolescents A Randomized Clinical Trial. Jama 310(24):2622–2630PubMedPubMedCentralCrossRef
13.
Mazzotta G, Gallai B, Mattioni A, Floridi F, Foti F, Allegretti M, D’Angelo R (2005) Cost assessment of headache in childhood and adolescence: preliminary data. J Headache Pain 6(4):281–283PubMedPubMedCentralCrossRef
14.
Mauskop A (2012) Nonmedication, alternative, and complementary treatments for migraine. Continuum (Minneap Minn) 18(4):796–806
15.
Weeks RE (2013) Application of behavioral therapies in adult and adolescent patients with chronic migraine. Neurol Sci 34(1):S11–S17PubMedCrossRef
16.
Basler HD, Franz C, Kröner-Herwig B, Rehfisch HP (eds) (2004) Psychologische Schmerztherapie. Springer, Berlin
17.
Damen L, Bruijn J, Koes BW, Berger MY, Passchier J, Verhagen AP (2006) Prophylactic treatment of migraine in children. Part 1. A systematic review of non-pharmacological trials. Cephalalgia 26(4):373–383PubMedCrossRef
18.
19.
Penzien DB, Irby MB, Smitherman TA, Rains JC, Houle TT (2015) Well-established and empirically supported behavioral treatments for migraine. Curr Pain Headache Rep 19:34PubMedCrossRef
20.
Robbins M, Grosberg BM, Lipton R (2013) Headache. In: Gross RA, Mink JW (eds) Neurology in Practice. Wiley-Blackwell, NY, USA. p 336
21.
Rathier L, Roth J (2015) A Biobehavioral Approach to Headache Management. In: Roth J (Ed) Headache Disorders, vol 26. Rhode Island Med J 98(2):26–28
22.
23.
Powers SW, Gilman DK, Hershey AD (2006) Suggestions for a biopsychosocial approach to treating children and adolescents who present with headache. Headache 46(3):S149–S150PubMedCrossRef
24.
Ramsey RR, Ryan JL, Hershey AD, Powers SW, Aylward BS, Hommel KA (2014) Treatment Adherence in Patients With Headache: A Systematic Review. Headache 54:795–816PubMedCrossRef
25.
Rapoff MA (2010) Adherence to Pediatric Medical Regimens, 2nd edn. Springer, New YorkCrossRef
26.
Winner P, Migraine (2009) Diagnosis and Treatment. In: Hershey AD, Powers SW, Winner P, Kabbouche MA (eds), Pediatric Headaches in Clinical Practice. John Wiley & Sons, Oxford. p 83–95
27.
Grazzi L, Andrasik F, Usai S, D’Amico D, Bussone G (2004) Pharmacological behavioural treatment for children and adolescents with tension-type headache: Preliminary data. Neurol Sci 25(3):S270–S271PubMedCrossRef
28.
Andrasik F, Grazzi L, Usai S, Bussone G (2007) Pharmacological treatment compared to behavioural treatment for juvenile tension-type headache: Results at two-year follow-up. Neurol Sci 28(2):S235–S238PubMedCrossRef
29.
Allen KD, McKeen LR (1991) Home-based multicomponent treatment of pediatric migraine. Headache 31:467–472PubMedCrossRef
30.
Engel JM (1993) Children’s compliance with progressive relaxation procedures for improving headache control. OTJR (Thorofare N J) 13:19–230
31.
Drotar D (ed) (2000) Promoting Adherence to Medical Treatment in Chronic Childhood Illness: Concepts, Methods, and Interventions. Lawrence Eribaum Associates, Mahwah
32.
33.
LaGreca AM, Schuman WB (1995) Adherence to prescribed medical regimens. In: Roberts MC (ed) Handbook of Pediatric Psychology. Guilford, New York, pp 55–83
34.
35.
Becker WJ, Gladstone JP, Aube M (2007) Migraine prevalence, diagnosis and disability. Can J Neurol Sci 34(4):S3–S9PubMed
36.
Craddock L, Lynne DR (2012) Pediatric migraine teaching for families. J Spec Pediatr Nurs 17(2):98–107PubMedCrossRef
37.
Antonaci F, Sances G, Guaschino E, De Cillis I, Bono G, Nappi G (2008) Meeting patient expectations in migraine treatment: What are the key endpoints? J Headache Pain 9:207–213PubMedPubMedCentralCrossRef
38.
39.
Zebenholzer K, Frantal S, Pablik E, Lieba-Samal D, Salhofer-Polanyi S, Wöber-Bingöl Ç, Wöber C (2016) Reliability of assessing lifestyle and trigger factors in patients with migraine - findings from the PAMINA study. Eur J Neurol 23(1):120–126PubMedCrossRef
40.
Chakravarty A, Mukherjee A, Roy D (2009) Trigger factors in childhood migraine: a clinic-based study from eastern India. J Headache Pain 10(5):375–380PubMedPubMedCentralCrossRef
41.
Neut D, Fily A, Cuvellier JC, Vallée L (2012) The prevalence of triggers in paediatric migraine: a questionnaire study in 102 children and adolescents. J Headache Pain 13(1):61–65PubMedCrossRef
42.
Fraga MD, Pinho RS, Andreoni S, Vitalle MS, Fisberg M, Peres MF, Vilanova LC, Masruha MR (2013) Trigger factors mainly from the environmental type are reported by adolescents with migraine. Arq Neuropsiquiatr 71(5):290–293PubMedCrossRef
43.
44.
45.
46.
Bruni O, Galli F, Guidetti V (1999) Sleep hygiene and migraine in children and adolescents. Cephalalgia 19(25):57–59PubMedCrossRef
47.
Connelly M, Miller T, Gerry G, Bickel J (2010) Electronic momentary assessment of weather changes as a trigger of headaches in children. Headache 50(5):779–789PubMedCrossRef
48.
Powers SW, Hershey AD, Coffey CS, Chamberlin LA, Ecklund DJ, Sullivan SM, Klingner EA, Yankey JW, Kashikar-Zuck S, Korbee LL, Costigan ML, Riss HH, Porter LL (2016) The Childhood and Adolescent Migraine Prevention (CHAMP) Study: A Report on Baseline Characteristics of Participants. Headache doi: 10.​1111/​head.​12810 [Epub ahead of print]
49.
Corletto E, Dal Zotto L, Resos A, Tripoli E, Zanchin G, Bulfoni C, Battistella PA (2008) Osmophobia in juvenile primary headaches. Cephalalgia 28(8):825–831PubMedCrossRef
50.
Connelly M, Bickel J (2011) An electronic daily diary process study of stress and health behavior triggers of primary headaches in children. J Pediatr Psychol 36(8):852–862PubMedCrossRef
51.
Esposito M, Ruberto M, Pascotto A, Carotenuto M (2012) Nutraceutical preparations in childhood migraine prophylaxis: effects on headache outcomes including disability and behaviour. Neurol Sci 33(6):1365–1368PubMedCrossRef
52.
53.
Menon S, Lea RA, Ingle S, Sutherland M, Wee S, Haupt LM, Palmer M, Griffiths LR (2015) Effects of dietary folate intake on migraine disability and frequency. Headache 55(2):301–309PubMedCrossRef
54.
Cayir A, Turan MI, Tan H (2014) Effect of vitamin D therapy in addition to amitriptyline on migraine attacks in pediatric patients. Braz J Med Biol Res 47(4):349–354PubMedPubMedCentralCrossRef
55.
Talebi M, Savadi-Oskouei D, Farhoudi M, Mohammadzade S, Ghaemmaghamihezaveh S, Hasani A, Hamdi A (2011) Relation between serum magnesium level and migraine attacks. Neurosciences (Riyadh) 16(4):320–323
56.
Patniyot IR, Gelfand AA (2016) Acute Treatment Therapies for Pediatric Migraine: A Qualitative Systematic Review. Headache Jan 56(1):49–70CrossRef
57.
O’Brien HL, Hershey AD (2010) Vitamins and paediatric migraine: Riboflavin as a preventative medication. Cephalalgia 30(12):1417–1418PubMedCrossRef
58.
O’Brien HL, Kabbouche MA, Kacperski J, Hershey AD (2015) Treatment of Pediatric Migraine. Curr Treat Options Neurol 17:1CrossRef
59.
Usai S, Grazzi L, Bussone G (2011) Ginkolide B as migraine preventative treatment in young age; results at 1-year follow-up. Neurol Sci 32(1):S197–S199PubMedCrossRef
60.
Sun-Edelstein C, Mauskop A (2009) Foods and supplements in the management of migraine headaches. Clin J Pain 25(5):446–452PubMedCrossRef
61.
Tepper SJ (2008) Complementary and alternative treatments for childhood headaches. Curr Pain Headache Rep 12(5):379–383PubMedCrossRef
62.
63.
Boćkowski L, Sobaniec W, Kułak W, Smigielska-Kuzia J (2008) Serum and intraerythrocyte antioxidant enzymes and lipid peroxides in children with migraine. J Pharmacol Rep 60(4):542–548
64.
Eidlitz-Markus T, Haimi-Cohen Y, Steier D, Zeharia A (2010) Effectiveness of nonpharmacologic treatment for migraine in young children. Headache 50(2):219–223PubMedCrossRef
65.
Sieberg CB, Huguet A, von Baeyer CL, Seshia S (2012) Psychological interventions for headache in children and adolescents. Can J Neurol Sci 39(1):26–34PubMedCrossRef
66.
Rains JC, Penzien DB, McCrory DC, Gray RN (2005) Behavioral headache treatment: history, review of the empirical literature, and methodological critique. Headache 45(2):S92–S109PubMedCrossRef
67.
Ehde MD, Dillworth MT, Turner JA (2014) Cognitive-Behavioral Therapy for Individuals With Chronic Pain. Am Psychol Assoc 69(2):153–166CrossRef
68.
Andrasik F (2003) Behavioral treatment approaches to chronic headache. Neurol Sci 24(2):S80–S85PubMed
69.
French DJ, Holroyd KA, Pinell C, Malinoski PT, O’Donnell F, Hill KR (2000) Perceived self-efficacy and headache-related disability. Headache 40(8):647–656PubMedCrossRef
70.
Penzien DB, Taylor FR (2014) Headache toolbox. Behavioral and other nonpharmacologic treatments for headache. Headache 54(5):955–956PubMedCrossRef
71.
Chiappedi M, Mensi MM, Termine C, Balottin U (2016) Psychological Therapy in Adolescents with Chronic Daily Headache. Curr Pain Headache Rep 20(1):3PubMedCrossRef
72.
Sieberg RGJ, McGrath PJ (1996) Psychological treatments for migraine. Biomed Pharmacother 50(2):58–63CrossRef
73.
Engel JM, Rapoff MA, Pressman AR (1992) Long-term follow-up of relaxation training for pediatric headache disorders. Headache 32(3):152–156PubMedCrossRef
74.
Powers SW, Hershey AD (2002) Biofeedback for childhood migraine. In: Maria BL (ed) Current Management in Child Neurology. BC Decker, Inc, Hamilton, pp 83–85
75.
Mullally WJ, Hall K, Goldstein R (2009) Efficacy of biofeedback in the treatment of migraine and tension type headaches. Pain Physician 12(6):1005–1011PubMed
76.
Balottin U, Ferri M, Racca M, Rossi M, Rossi G, Beghi E, Chiappedi M, Termine C (2014) Psychotherapy versus usual care in pediatric migraine and tension-type headache: a single-blind controlled pilot study. Ital J Pediatr 40:6PubMedPubMedCentralCrossRef
77.
Kröner-Herwig B (2014) Headache in children and adolescents. Epidemiology, biopsychosocial correlates, and psychological treatment approaches. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 57(8):928–934PubMedCrossRef
78.
Holroyd KA, Cottrell CK, O’Donnell FJ, Cordingley GE, Drew JB, Carlson BW, Himawan L (2010) Effect of preventive (beta blocker) treatment, behavioural migraine management, or their combination on outcomes of optimised acute treatment in frequent migraine: randomised controlled trial. BMJ 341:c4871PubMedPubMedCentralCrossRef
79.
Levine M (2008) Comprehensive Review of Headache Medicine, Oxford University Press. p 336
80.
Kandel ER (1998) A new intellectual framework for psychiatry. J Psychiatry 155(4):457–469
81.
Gabbard GO (2000) A neurobiologically informed perspective on psychotherapy. Br J Psychiatry 177:117–122PubMedCrossRef
82.
Mayford M, Siegelbaum SA, Kandel ER (2012) Synapses and memory storage. Cold Spring Harb Perspect Biol. 4(6)
83.
Beauregard M (2014) Functional neuroimaging studies of the effects of psychotherapy. Dialogues Clin Neurosci 16(1):75–81PubMedPubMedCentral
84.
Janiri L, Guglielmo R, Bruschi A (2009) Psicoterapia e neuroscienze:l'integrazione possibile. Modelli per la mente, 2(2):7-13
85.
Mundo E (2006) Neurobiology of dynamic psychotherapy: an integration possible? J Am Acad Psychoanal Dyn Psychiatry 34(4):679–691PubMedCrossRef
86.
87.
Frewen PA, Dozois DJ, Lanius RA (2008) Neuroimaging studies of psychological interventions for mood and anxiety disorders: empirical and methodological review. Clin Psychol Rev 28(2):228–246PubMedCrossRef
88.
Bennett S, Shafran R, Coughtrey A, Walker S, Heyman I (2015) Psychological interventions for mental health disorders in children with chronic physical illness: a systematic review. Arch Dis Child 100:308–316PubMedCrossRef
89.
Cousins S, Ridsdale L, Goldstein LH, Noble AJ, Moorey S, Seed P (2015) A pilot study of cognitive behavioural therapy and relaxation for migraine headache: a randomised controlled trial. J Neurol 262(12):2764–2772PubMedPubMedCentralCrossRef
90.
Fisher E, Heathcote L, Palermo TM, Williams AC, Lau J, Eccleston C (2014) Systematic Review and Meta-Analysis of Psychological Therapies for Children With Chronic Pain. J Pediatr Psychol 39(8):763–782PubMedPubMedCentralCrossRef
91.
Holroyd KA (2002) Assessment and psychological management of recurrent headache disorders. J Consult Clin Psych 70:656–677CrossRef
92.
Penzien DB, Rains JC, Andrasik F (2002) Behavioral management of recurrent headache: Three decades of experience and empiricism. Appl Psychophysiol Biofeedback 27:163–181PubMedCrossRef
93.
Andrasik F (2007) What does the evidence show? Efficacy of behavioural treatments for recurrent headaches in adults. Neurol Sci 28:70–77CrossRef
94.
Chen YZ, Li N, Zhou KY (2014) Preventive effect of behavioral therapy plus flunarizine in children with migraine. Zhongguo Dang Dai Er Ke Za Zhi 16(11):1105–1108PubMed
95.
Eccleston C, Yorke L, Morley S, Williams AC, Mastroyannopoulou K (2003) Psychological therapies for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev 1, CD003968PubMed
96.
Kohen DP (2010) Long-term follow-up of self-hypnosis training for recurrent headaches: what the children say. Int J Clin Exp Hypn 58(4):417–432PubMedCrossRef
97.
Sierpina V, Astin J, Giordano J (2007) Mind-body therapies for headache. Am Fam Physician 76(10):1518–1522PubMed
98.
Olness K, MacDonald JT, Uden DL (1987) Comparison of self-hypnosis and propranolol in the treatment of juvenile classic migraine. Pediatrics 79(4):593–597PubMed
99.
Kohen DP (2011) Chronic daily headache: helping adolescents help themselves with self-hypnosis. Am J Clin Hypn 54(1):32–46PubMedCrossRef
100.
Trautmann E, Lackschewitz H, Kröner-Herwig B (2006) Psychological treatment of recurrent headache in children and adolescents—a meta-analysis. Cephalalgia 26(12):1411–1426PubMedCrossRef
101.
Kropp P, Meyer B, Landgraf M, Ruscheweyh R, Ebinger F, Straube A (2013) Headache in children: update on biobehavioral treatments. Neuropediatrics 44(1):20–24PubMedCrossRef
102.
103.
Blume HK, Brockman LN, Breuner CC (2012) Biofeedback therapy for pediatric headache: factors associated with response. Headache 52(9):1377–1386PubMedCrossRef
104.
Palermo TM, Eccleston C, Lewandowski AS, Williams AC, Morley S (2010) Randomized controlled trials of psychological therapies for management of chronic pain in children and adolescents: an updated meta-analytic review. Pain 148(3):387–397PubMedCrossRef
105.
Fisher E, Law E, Palermo TM, Eccleston C (2010) Psychological therapy (remotely delivered) for the management of chronic pain and recurrent pain in Ch and Adol. Cochrane Database System, 2015 combination on outcomes of optimised acute treatment in frequent migraine: randomised controlled trial. BMJ 341:c4871CrossRef
106.
Silberstein SD (2000) Practice parameter: evidence-based guidelines for migraine headache (an evidence-based review) report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 55(6):754–762PubMedCrossRef
107.
Penzien DB, Irby MB (2014) Insights on treatment mechanisms of cognitive-behavioral migraine therapy. Headache 54(9):1439–1440PubMedCrossRef
108.
Goldfriend MR, Castonguay LG (1993) Behavior Therapy: Redefining Strenghts and Limitations. Behav Ther 24:505–S26CrossRef
109.
Wright JH, Davis D (1994) The Therapeutic Relationship in Cognitive-Behavioral Therapy: Patient Perceptions and Therapist Responses. Cogn Behav Pract 1:25–45CrossRef
110.
Kropf P, Greene RR (2012) Cognitive and Behavioral Approaches: In Kropf P, Greene RR, Competence: Theoretical Frameworks. Aldine Transaction, Transaction Publishers, New Brunswick, NewJersey, 232 pp
111.
Leahy RL (2006) A Relational Approach to Negotiating Alliance Ruptures. In: Leahy RL, Roadblocks in Cognitive-Behavioral Therapy: Transforming Challenges Into Opportunities for Change. Guilford Press, New York. pp 364
112.
113.
Rains JC, Penzien DB (2005) Behavioral research and the double-blind placebo-controlled methodology: challenges in applying the biomedical standard to behavioral headache research. Headache 45:479–486PubMedCrossRef
114.
Termine C, Ozge A, Antonaci F, Natriashvili S, Guidetti V, Wöber-Bingöl C (2011) Overview of diagnosis and management of paediatric headache. Part II: therapeutic management. J Headache Pain 12(1):25–34PubMedCrossRef
115.
Health E-BC, Editorial Office (2013) Clinical Answers: Are nonpharmacological interventions for migraine effective in children and Adolescents. Evid-Based Child Health 8:754–758CrossRef
116.
Grazzi L, D’Amico D, Leone M, Moschiano F, Bussone G (1998) Pharmacological and behavioral treatment of pediatric migraine and tension-type headache. Ital J Neurol Sci 19(2):59–64PubMedCrossRef
117.
Kohen DP, Zajac R (2007) Self-hypnosis training for headaches in children and adolescents. J Pediatr 150(6):635–639PubMedCrossRef
Metadata
Title
Behavioral management of headache in children and adolescents
Authors
Noemi Faedda
Rita Cerutti
Paola Verdecchia
Daniele Migliorini
Marco Arruda
Vincenzo Guidetti
Publication date
01-12-2016
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-016-0671-4

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