Top

Published in:

01-05-2013 | Translational Neurosciences - Original Article

Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine

Authors: Min J. Lee, Keith D. Burau, Nachum Dafny

Published in: Journal of Neural Transmission | Issue 5/2013

Abstract

Cocaine is one of well-known drugs of abuse, and many children experience early exposure to cocaine. Because of an immature neuronal system in adolescents, they may react differently to repeated cocaine administration compared to adults. Most of the published papers report the effect of cocaine on adult male rats and this paper focused on the effects of cocaine on the 24 h locomotor activity rhythm patterns activity of adolescent Sprague Dawley (SD) female rats. Changes in the locomotor activity rhythm patterns could indicate that cocaine elicits long-term changes in the clock genes of the body that regulate different physiological processes. The objective of this study was to investigate whether cocaine in adolescent female rats modulated their daily activity pattern. Animals were divided into control (saline), 3.0, 7.5, 15.0 mg/kg cocaine groups. On experimental day 1 (ED 1), all groups were given saline injection. From ED 2 to ED 7, either saline or cocaine (3.0, 7.5, or 15.0 mg/kg) was given daily. ED 8 to ED 10 were the washout days, where no injection was given. On ED 11, the animals were injected with saline or with the same dose of cocaine as they were treated on ED 2 to ED 7. Each animal’s locomotor activities was recorded nonstop following saline or cocaine injection for 11 consecutive days using the open field assay. In conclusion, it was observed that all three groups receiving repeated cocaine administration (3.0, 7.5, and 15.0 mg/kg) displayed significantly altered locomotor activity rhythm patterns.

Abarca C, Albrecht U, Spanagel R (2002) Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proc Natl Acad Sci USA 99:9026–9030PubMedCrossRef

Algahim MF, Yang PB, Wilcox VT, Burau KD, Swann AC, Dafny N (2009) Prolonged methylphenidate treatment alters the behavioral diurnal activity pattern of adult male Sprague-Dawley rats. Pharmacol Biochem Behav 92(1):93–99PubMedCrossRef

Algahim MF, Yang PB, Burau KD, Swann AC, Dafny N (2010) Repetitive ritalin treatment modulates the diurnal activity pattern of young SD male rats. Cent Nerv Syst Agents Med Chem 10:247–257PubMedCrossRef

Antle MC, van Diepen HC, Deboer T, Pedram P, Pereira RR, Meijer JH (2012) Methylphenidae modifies the motion of the circadian clock. Neurpsychopharmacology 37:2446–2455CrossRef

Askenasy EP, Taber KH, Yang PB, Dafny N (2007) Methylphenidate (ritalin): behavioral studies in the rat. Int J Neurosci 117:757–794PubMedCrossRef

Becker JB, Molenda H, Hummer DL (2001) Gender differences in the behavioral response to cocaine and amphetamine. Implications for mechanisms mediating gender differences in drug abuse. Ann NY Acad Sci 937:172–187PubMedCrossRef

Bergheim M, Yang PB, Burau KD, Dafny N (2012) Adolescent rat circadian activity is modulated by psychostimulants. Brain Res 1431:35–45PubMedCrossRef

Bingham C, Arbogast B, Guillaume GC, Lee JK, Halberg F (1982) Inferential statistical methods for estimating and comparing cosinor parameters. Chronobiologia 9:397–439PubMed

Black YD, Maclaren FR, Naydenov AV, Carlezon WA Jr, Baxter MG, Konradi C et al (2006a) Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci 26:9656–9665PubMedCrossRef

Black YD, Maclaren FR, Naydenov AV, Carlezon WA Jr, Baxter MG, Konradi C et al (2006b) Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci 26:9656–9665PubMedCrossRef

Brecht ML, O’Brien A, von Mayrhauser C, Anglin MD (2004) Methamphetamine use behaviors and gender differences. Addict Behav 29:89–106PubMedCrossRef

Chen JC, Chen PC, Chiang YC (2009) Molecular mechanisms of psychostimulant addiction. Chang Gung Med J 32:148–154PubMed

Chou TC, Scammell TE, Gooley JJ, Gaus SE, Saper CB, Lu J (2003) Critical role of dorsomedial hypothalamus nucleus in a wide range of behavioral circadian rhythms. J Neursci 23(33):10691–10702

Chong SL, Claussen CM, Dafny N (2012) Nucleus accumbens neuronal activity in freely behaving rats is modulated following acute and chronic methylphenidate administration. Brain Res Bull 87:445–456PubMedCrossRef

Claussen CM, Dafny N (2012) Acute and chronic methylphenidate modulates the neuronal activity of the caudate nucleus recorded from freely behaving rats. Brain Res Bull 87:387–396PubMedCrossRef

Claussen CM, Chong SL, Dafny N (2012) Selective bilateral lesion to caudate nucleus modulates the acute and chronic methylphenidate effects. Pharmacol Biochem Behav 101:208–216PubMedCrossRef

Collins SL, Izenwasser S (2002) Cocaine differentially alters behavior and neurochemistry in periadolescent versus adult rats. Brain Res Dev Brain Res 138:27–34PubMedCrossRef

Dafny N, Yang PB (2006) The role of age, genotype, sex, and route of acute and chronic administration of methylphenidate: a review of its locomotor effects. Brain Res Bull 68:393–405PubMedCrossRef

Davis FC, Darrow JM, Menaker M (1983) Sex differences in the circadian control of hamster wheel-running activity. Am J Physiol 244:93–105

Duffy JF, Cain SW, Chang AM, Phillips AJ, Münch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright KP Jr, Czeisler CA (2011) Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proc Natl Acad Sci USA 108: 15602–15608PubMedCrossRef

Eaton et al. (2010) Youth risk behavior surveillance—United States, 2009. Centers for disease control and prevention. Surveillance summaries. MMWR, 59

Estroff TW, Schwartz RH, Hoffmann NG (1989) Adolescent cocaine abuse. Addictive potential, behavioral and psychiatric effects. Clin Pediatr 28:550–555CrossRef

Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8:1481–1489PubMedCrossRef

Gaytan O, Ghelani D, Martin S, Swann A, Dafny N (1997) Methylphenidate: diurnal effects on locomotor and stereotypic behavior in the rat. Brain Res 777:1–12PubMedCrossRef

Gaytan O, Lewis C, Swann A, Dafny N (1999) Diurnal differences in amphetamine sensitization. Eur J Pharmacol 374:1–9PubMedCrossRef

Gaytan O, Yang P, Swann A, Dafny N (2000) Diurnal differences in sensitization to methylphenidate. Brain Res 864:24–39PubMedCrossRef

Giorgetti M, Zhdanova IV (2000) Chronic cocaine treatment induces dysregulation in the circadian pattern of rats’ feeing behavior. Brain Res 877:170–175PubMedCrossRef

Glaser AM, Reyes-Vázquez C, Prieto-Gómez B, Burau K, Dafny N (2012) Morphine administration and abrupt cessation alter the behavioral diurnal activity pattern. Pharmacol Biochem Behav 101:544–552PubMedCrossRef

Guerriero RM, Hayes MM, Dhaliwal SK, Ren JQ, Kosofsky BE (2006) Preadolescent methylphenidate versus cocaine treatment differ in the expression of cocaine-induced locomotor sensitization during adolescence and adulthood. Biol Psychiatry 60:1171–1180PubMedCrossRef

Hernandez-Avila CA, Rounsaville BJ, Kranzler HR (2004) Opioid-, cannabis- and alcohol-dependent women show more rapid progression to substance abuse treatment. Drug Alcohol Depend 74:265–272PubMedCrossRef

Izenwasser S (2005) Differential effects of psychoactive drugs in adolescents and adults. Crit Rev Neurobiol 17:51–67PubMedCrossRef

Kalivas PW, O’Brien C (2008) Drug addiction as a pathology of staged neuroplasticity. Neuropsychopharmacology 33:166–180PubMedCrossRef

Kalivas PW, Stewart J (1991) Dopamine transmission in the initiation and expression of drug- and stress-induced sensitization of motor activity. Brain Res Rev 16:223–244PubMedCrossRef

Klein DC, Moore RY, Reppert SM (1991) Suprachiastimatic nucleus: the minds clock. Oxford UP, New York

Laviola G, Wood RD, Kuhn C, Francis R, Spear LP (1995) Cocaine sensitization in periadolescent and adult rats. J Pharmacol Exp Ther 275:345–357PubMed

Lee MJ, Yang PB, Wilcox VT, Burau KD, Swann AC, Dafny N (2009) Does repetitive ritalin injection produce long term effects on SD female adolescent rats? Neuropharmacology 57:201–207PubMedCrossRef

Lee MJ, Yang PB, Wilcox VT, Burau KD, Swann AC, Dafny N (2011) Repetitive methylphenidate administration modulates the diurnal behavioral activity pattern of adult female SD rats. J Neural Transm 118:285–298PubMedCrossRef

Lynch WJ (2008) Acquisition and maintenance of cocaine self-administration in adolescent rats: effects of sex and gonadal hormones. Psychopharmacology 197:237–246PubMedCrossRef

Lynch WJ, Girgenti MJ, Breslin FJ, Newton SS, Taylor JR (2008) Gene profiling the response to repeated cocaine self-administration in dorsal striatum: a focus on circadian genes. Brain Res 1213:166–177PubMedCrossRef

Manev H, Uz T (2006) Clock genes: influencing and being influenced by psychoactive drugs. Trends Pharmacol Sci 27:186–189PubMedCrossRef

McClung CA, Sidiropoulou K, Vitaterna M, Takahashi JS, White FJ, Cooper DC, Nestler EJ (2005) Regulation of dopaminergic transmission and cocaine reward by the Clock gene. Proc Natl Acad Sci USA 102:9377–9381PubMedCrossRef

Mong JA, Baker FC, Mahoney MM, Paul KN, Schwartz MD, Semba K, Silver R (2011) Sleep, rhythms, and the endocrine brain: influence of sex and gonadal hormones. J Neurosci 31:16107–16116PubMedCrossRef

Moore RY, Lenn NJ (1972) A retinohypothalamic projection in the rat. J Comp Neurol 146:1–14PubMedCrossRef

Nestler EJ (2002) Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem 78:637–647PubMedCrossRef

Niculescu M, Ehrlich ME, Unterwald EM (2005) Age-specific behavioral responses to psychostimulants in mice. Pharmacol Biochem Behav 82:280–288PubMedCrossRef

Norrell S, Reyes-Vasquez C, Burau K, Dafny N (2010) Alcohol usage and abrupt cessation modulate diurnal activity. Brain Res Bull 83:57–64PubMedCrossRef

Parylak SL, Caster JM, Walker QD, Kuhn CM (2008) Gonadal steroids mediate the opposite changes in cocaine-induced locomotion across adolescence in male and female rats. Pharmacol Biochem Behav 89:314–323PubMedCrossRef

Podet A, Lee MJ, Swanna AC, Dafny N (2010) Nucleus accumbens lesions modulates the effects of methylphenidate. Brain Res Bull 82:293–301PubMedCrossRef

Robinson TE, Becker JB (1986) Enduring changes in brain and behavior produced by chronic amphetamine administration: a review and evaluation of animal models of amphetamine psychosis. Brain Res 11:157–198CrossRef

Salek RL, Claussen CM, Pérez A, Dafny N (2012) Acute and chronic methylphenidate alters prefrontal cortex neuronal activity recorded from freely behaving rats. Eur J Pharmacol 679:60–67PubMedCrossRef

SAMHSA (2011) Substance abuse and mental health services administration, results from the 2010 National survey on drug use and health: summary of national findings, NSDUH Series H-41, HHS publication No (SMA) 11-4658. Rockville, MD

Schull J, Walker J, Fitzgerald K, Hiilivirta L, Ruckdeschel J, Schumacher D, Stanger D, McEachron DL (1989) Effects of sex, thyro-parathyroidectomy, and light regime on levels and circadian rhythms of wheel-running in rats. Physiol Behav 46:341–346PubMedCrossRef

Sell SL, Scalzitti JM, Thomas ML, Cunningham KA (2000) Influence of ovarian hormones and estrous cycle on the behavioral response to cocaine in female rats. J Pharmacol Exp Ther 293:879–886PubMed

Shin JW, Greeling JC, Loewy AD (2008) Inputs to the ventrolateral bed nucleus of the stria terminalis. J Comp Neurol 511:628–657PubMedCrossRef

Sillivan SE, Black YD, Naydenov AV, Vassoler FR, Hanlin RP, Konradi C (2011) Binge cocaine administration in adolescent rats affects amygdalar gene expression patterns and alters anxiety-related behavior in adulthood. Biol Psychiatry 70:583–592PubMedCrossRef

Uz T, Ahmed R, Akhisaroglu M, Kurtuncu M, Imbesi M, Dirim Arslan A, Manev H (2005) Effect of fluoxetine and cocaine on the expression of clock genes in the mouse hippocampus and striatum. Neuroscience 134:1309–1316PubMedCrossRef

Wiley JL, Evans RL, Grainger DB, Nicholson KL (2011) Locomotor activity changes in female adolescent and adult rats during repeated treatment with a cannabinoid or club drug. Pharmacol Rep 63:1085–1092PubMed

Yang PB, Swann AC, Dafny N (2003) Chronic pretreatment with methylphenidate induces cross-sensitization with amphetamine. Life Sci 73:2899–2911PubMedCrossRef

Yang PB, Swann AC, Dafny N (2006) Acute and chronic methylphenidate dose-response assessment on three adolescent male rat strains. Brain Res Bull 71:301–310PubMedCrossRef

Yang PB, Swann AC, Dafny N (2010) Psychostimulants given in adolescence modulate their effects in adulthood using the open field and the wheel-running assays. Brain Res Bull 82:208–217PubMedCrossRef

Yang PB, Cuellar DO 3rd, Swann AC, Dafny N (2011) Age and genetic strain differences in response to chronic methylphenidate administration. Behav Brain Res 218:206–217PubMedCrossRef

Yuferov V, Kroslak T, Laforge KS, Zhou Y, Ho A, Kreek MJ (2003) Differential gene expression in the rat caudate putamen after “binge” cocaine administration: advantage of triplicate microarray analysis. Synapse 48:157–169PubMedCrossRef

Yuferov V, Butelman ER, Kreek MJ (2005) Biological clock: biological clocks may modulate drug addiction. Eur J Hum Genet 13(10):1101–1103PubMedCrossRef

Zakharova E, Wade D, Izenwasser S (2009) Sensitivity to cocaine conditioned reward depends on sex and age. Pharmacol Biochem Behav 92:131–134PubMedCrossRef

Title: Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine
Authors: Min J. Lee
Keith D. Burau
Nachum Dafny
Publication date: 01-05-2013
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 5/2013
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-012-0929-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Behavioral daily rhythmic activity pattern of adolescent female rat is modulated by acute and chronic cocaine

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 5/2013

Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer’s disease

Repetitive transcranial magnetic stimulation combined with cognitive training is a safe and effective modality for the treatment of Alzheimer’s disease: a randomized, double-blind study

Repeated administration of imipramine modifies GABAergic transmission in rat frontal cortex

Remodeling of the fovea in Parkinson disease

Effects of dopaminergic and subthalamic stimulation on musical performance

Dorsal raphe neuronal activities are modulated by methylphenidate