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BMC Public Health
Published in: BMC Public Health 1/2010

Open Access 01-12-2010 | Research article

BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders

Authors: Victoria Arija, Marta Ferrer-Barcala, Nuria Aranda, Josepa Canals

Published in: BMC Public Health | Issue 1/2010

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Abstract

Background

Eating disorders (ED) have a multifactorial aetiology in which genetics play an important role. Several studies have found an association between the Val66Met (G196A) polymorphism of the Brain-Derived Neurotrophic Factor (BDNF) and Eating disorders.
The aim of this study was to determine the association of the Val66Met (G196A) polymorphism of the BDNF gene and its effect on eating disorders (ED), energy intake and BMI in schoolchildren.

Methods

Two-year cohort study (preadolescence to adolescence). From an initial sample of 1336 Caucasian children (mean age = 11.37 years), a group at risk of ED (n = 141) and a control group (n = 117) were selected using the Children's Eating Attitudes Test. Two years later, they were re-classified into an at-risk group (n = 41) and a control group (n = 159) using the Eating Attitudes Test. The diagnosis of the individuals at risk of ED was confirmed by means of the Diagnostic Interview for Children and Adolescents. BMI, energy intake and the Val66Met (G196A) polymorphism of the BDNF gene were analysed in the at-risk and control groups.

Results

The frequency of genotypes of the Val66Met (G196A) polymorphism of the BDNF gene is 28.6% (95% CI: 22.4-34.9) in the heterozygous form (Val/Met) and 5% (95% CI: 2.4-9) in the homozygous form (Met/Met). We detected no association between Val66Met genotypes and the severity of ED. Over time, the carriers of the Met66 allele with a persistent risk of ED significantly restricted energy intake (507 Kcal/day; p = 0.033).

Conclusion

We have not found an association between Val66Met (G196A) polymorphism of the BDNF and ED in schoolchildren from general population. The relationship found between this polymorphism and energy intake restriction in adolescents with a persistent risk of ED should be replicated in a larger sample.
Appendix
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Literature
1.
Olesti M, Piñol JL, Martín N, de la Fuente M, Riera A, Bofarull JM, Ricomà CG: Prevalence of anorexia nervosa, bulimia nervosa and other eating disorders in adolescent girls in Reus (Spain). An Pediatr (Barc). 2008, 68: 18-23. 10.1157/13114466.CrossRef
2.
Rodríguez-Cano T, Beato-Fernández L, Belmonte-Llario A: New contributions to the prevalence of eating disorders in Spanish adolescents: detection of false negatives. Eur Psychiatry. 2005, 20: 173-178. 10.1016/j.eurpsy.2004.04.002.CrossRefPubMed
3.
Vega AT, Rasillo MA, Lozano JE, Rodríguez G, Franco M: Eating disorders. Prevalence and risk profile among secondary school students. Soc Psychiatry Psychiatr Epidemiol. 2005, 10: 980-987. 10.1007/s00127-005-0996-9.CrossRef
4.
Vanderheyden DA, Boland FJ: A comparison of normal, mild, moderate and severe binge-eaters and binge-vomiters using discriminant function analysis. Int J Eat Disord. 1987, 6: 331-337. 10.1002/1098-108X(198705)6:3<331::AID-EAT2260060302>3.0.CO;2-M.CrossRef
5.
Franko D, Omori M: Subclinical eating disorders in adolescent girls: a test of the continuity hypotesis and its psychological correlates. J Adolesc. 1999, 22: 389-396. 10.1006/jado.1999.0230.CrossRefPubMed
6.
Stice E, Killer J, Hayward C, Taylor C: Support for the continuity hypothesis of bulimic pathology. J Consult Clin Psychol. 1998, 66: 784-790. 10.1037/0022-006X.66.5.784.CrossRefPubMed
7.
Leibrock J, Lottspeich F, Hohn A, Hofer M, Hengerer B, Masiakowski P: Molecular cloning and expression of brain-derived neurotrophic factor. Nature. 1989, 341: 149-152. 10.1038/341149a0.CrossRefPubMed
8.
Tapia-Arancibia L, Rage F, Givalois L, Arancibia S: Physiology of BDNF: focus on hypothalamic function. Front Neuroendocrinol. 2004, 25: 77-107. 10.1016/j.yfrne.2004.04.001.CrossRefPubMed
9.
Bersani G, Iannitelli A, Fiore M, Angelucci F, Aloe L: Data and hypotheses on the role of nerve growth factor and other neurotrophins in psychiatric disorders. Medi Hypotheses. 2000, 55: 199-207. 10.1054/mehy.1999.1044.CrossRef
10.
Lang UE, Jockers-Scherubl MC, Hellweg R: State of the art of the neurotrophin hypothesis in psychiatric disorders: Implications and limitations. J Neural Transm. 2004, 111: 387-411. 10.1007/s00702-003-0100-0.CrossRefPubMed
11.
Chen ZY, Patel PD, Sant G, Meng CX, Teng KK, Hempstead BL: Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons. J Neurosci. 2004, 24: 4401-4411. 10.1523/JNEUROSCI.0348-04.2004.CrossRefPubMed
12.
Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A: The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell. 2003, 112: 257-269. 10.1016/S0092-8674(03)00035-7.CrossRefPubMed
13.
Hanson IM, Seawright A, van Heyningen V: The human BDNF gene maps between FSHB and VBS1 at the boundary of 11p13-p14. Genomics. 1992, 13: 1331-1333. 10.1016/0888-7543(92)90060-6.CrossRefPubMed
14.
Ribasés M, Gratacòs M, Armengol L, de Cid R, Badía A, Jiménez L: Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type. Mol Psychiatry. 2003, 8: 745-751. 10.1038/sj.mp.4001281.CrossRefPubMed
15.
Ribasés M, Gratacòs M, Fernández-Aranda F, Bellodi L, Boni C, Anderluh M: Association of BDNF with restricting anorexia nervosa and minimum body mass index: a family-based association study of eight European populations. Eur J Hum Genet. 2005, 13: 428-434. 10.1038/sj.ejhg.5201351.CrossRefPubMed
16.
Koizumi H, Hashimoto K, Itoh K, Nakazato M, Shimizu E, Ohgake S: Association between the brain-derived neurotrophic factor G196A polymorphism and eating disorders. Am J Med Genet B Neuropsychiatr Genet. 2004, 127: 125-127. 10.1002/ajmg.b.20153.CrossRef
17.
Monteleone P, Zanardini R, Tortorella A, Gennarelli M, Castaldo E, Canestrelli B: The 196G/A (val66met) polymorphism of the BDNF gene is significantly associated with binge eating behavior in women with bulimia nervosa or binge eating disorder. Neurosci Lett. 2006, 406: 133-137. 10.1016/j.neulet.2006.07.040.CrossRefPubMed
18.
Gratacòs M, González JR, Mercader JM, de Cid R, Urretavizcaya M, Estivill X: Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia. Biol Psychiatry. 2007, 61: 911-922. 10.1016/j.biopsych.2006.08.025.CrossRefPubMed
19.
Dardennes RM, Zizzari P, Tolle V, Foulon C, Kipman A, Romo L: Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset. Psychoneuroendocrinology. 2007, 32: 106-113. 10.1016/j.psyneuen.2006.11.003.CrossRefPubMed
20.
Friedel S, Horro FF, Wermter AK, Geller F, Dempfle A, Reichwald K: Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet. 2005, 132: 96-99.CrossRef
21.
Thoenen H: Neurotrophind and neuronal plasticity. Science. 1995, 270: 593-8. 10.1126/science.270.5236.593.CrossRefPubMed
22.
23.
Coppola V, Tessarollo T: Control of hyperphagia prevents obesity in BDNF heterozygous mice. Neuroreport. 2004, 15: 2665-2668. 10.1097/00001756-200412030-00022.CrossRefPubMed
24.
Bariohay B, Lebrun B, Moyse E, Jean A: Brain-derived neurotrophic factor plays a role as an anorexigenic factor in the dorsal vagal complex. Endocrinology. 2005, 146: 5612-5620. 10.1210/en.2005-0419.CrossRefPubMed
25.
Lebrun B, Bariohay B, Moyse E, Jean A: Brain-derived neurotrophic factor (BDNF) and food intake regulation: A minireview. Autonomic Neuroscience. 2006, 126-127: 30-38. 10.1016/j.autneu.2006.02.027.CrossRefPubMed
26.
Gunstad J, Schofield P, Paul RH, Spitznagel MB, Cohen RA, Williams LM: BDNF Val66Met Polymorphism Is Associated with Body Mass Index in Healthy Adults. Neuropsychobiology. 2006, 53: 153-157. 10.1159/000093341.CrossRefPubMed
27.
Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL: A DRD4/BDNF gene-gene interaction associated with maximum BMI in women with bulimia nervosa. Int J Eat Disord. 2008, 41: 22-28. 10.1002/eat.20474.CrossRefPubMed
28.
Sancho C, Arija MV, Asorey O, Canals J: Epidemiology of eating disorders: a two year follow up in an early adolescent school population. Eur Child Adolesc Psychiatry. 2007, 16: 495-504. 10.1007/s00787-007-0625-0.CrossRefPubMed
29.
Sancho C, Asorey O, Arija V, Canals J: Psychometric characteristics of the Children's Eating Attitudes Test in a Spanish sample. Eur Eat Disorders. 2005, 13: 338-343. 10.1002/erv.643.CrossRef
30.
Castro J, Toro J, Salamero M, Guimerà E: The Eating Attitudes Test: validation of the Spanish version. Psychol Assess. 1991, 7: 175-190.
31.
Maloney MJ, Mc Guire J, Dabiels SR: Reliability testing of a children's version of the Eating Attitudes Test. J Am Acad Child Adolesc Psychiatry. 1998, 27: 541-543. 10.1097/00004583-198809000-00004.CrossRef
32.
Garner DM, Garfinkel PE: The Eating Attitudes Test: an index of the symptoms of anorexia nervosa. Psychol Med. 1979, 2: 273-279. 10.1017/S0033291700030762.CrossRef
33.
Canals J, Carbajo G, Fernadez-Ballart J: Discriminant validity of the Eating Attitudes Test according to American Psychiatric Association and World Health Organization criteria of eating disorders. Pychol Rep. 2002, 3: 1052-1056.CrossRef
34.
Ezpeleta L, de la Osa N, Doménech JM, Navarro JB, Losilla JM: Fiabilidad test-retest de la adaptación española de la Diagnostic Interview for Children and Adolescents-DICA-R. Psicothema. 1997, 9: 529-539.
35.
Reich W: Diagnostic interview for children and adolescents (DICA). J Am Acad Child Adolesc Psychiatry. 2000, 39: 59-66. 10.1097/00004583-200001000-00017.CrossRefPubMed
36.
Reich W, Leacock N, Shanfeld K: DICA-IV Diagnostic Interview for children and Adolescents-IV [Computer software]. 1997, Toronto, Ontario: Multi-Health Systems, Inc
37.
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, (DSM-IV). 1994, Washington: American Psychiatric Association, 4
38.
Thompson FE, Byers T: Dietary assessment resource manual. J Nutr. 1994, 124 (Suppl 11): 2245-2317.
39.
Beaton GH, Miler J, Corey P, Mc Guire V, Cousins M, Stewart E, et al: Sources of variances in 24-hours dietary recall data: implications for nutrition study design and interpretation. Am J Clin Nutr. 1979, 2: 2546-2549.
40.
Pekarinen M: Methology in the colletion of food consumption data. World Rev Nutr Diet. 1970, 2: 145-171.CrossRef
41.
Favier JC, Ireland-Ripert J, Toque C, Feinberg M: Répertoire general des aliments. Table de composition. 1995, Paris: INRA editions, Tec & Doc-Lavoisier, 2
42.
Mataix J: Tabla de composición de los alimentos Española. 1995, Granada (Spain): Servicio de publicaciones de la universidad de Granada, 2
43.
Shimizu E, Hashimoto K, Iyo M: Ethnic difference of the BDNF 196G/A (val66met) polymorphism frequencies: the possibility to explain ethnic mental traits. Am J Med Genet B Neuropsychiatr Genet. 2004, 126: 122-123. 10.1002/ajmg.b.20118.CrossRef
44.
Ribasés M, Gratacòs M, Fernández-Aranda F, Bellodi L, Boni C, Anderluh M, Cavallini MC, Cellini E, Di Bella D, Erzegovesi S, Foulon C, Gabrovsek M, Gorwood P, Hebebrand J, Hinney A, Holliday J, Hu X, Karwautz A, Kipman A, Komel R, Nacmias B, Remschmidt H, Ricca V, Sorbi S, Wagner G, Treasure J, Collier DA, Estivill X: Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet. 2004, 13: 1205-1212. 10.1093/hmg/ddh137.CrossRefPubMed
45.
Babio N, Canals J, Fernández-Ballart J, Arija V: Non-clinical adolescent girls at risk of eating disorder: under-reporters or restrained eaters?. Nutr Hosp. 2008, 23: 27-34.PubMed
46.
Sancho C, Arija MV, Asorey O, Canals J: Epidemiology of eating disorders: a two year follow up in an early adolescent school population. Eur Child Adolesc Psychiatry. 2007, 16: 495-504. 10.1007/s00787-007-0625-0.CrossRefPubMed
47.
Babio N, Canals J, Pietrobelli A, Pérez S, Arija V: A two-phase population study: relationships between overweight, body composition and risk of eating disorders. Nutr Hosp. 2009, 24: 485-91.PubMed
48.
Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, Helgadottir A, et al: Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet. 2009, 41: 18-24. 10.1038/ng.274.CrossRefPubMed
49.
Itoh K, Hashimoto K, Kumakiri C, Shimizu E, Iyo M: Association between brain- derived neurotrophic factor 196 G/A polymorphism and personality traits in healthy participants. Am J Med Genet B Neuropsychiatr Genet. 2004, 124: 61-63. 10.1002/ajmg.b.20078.CrossRef
50.
Sen S, Nesse RM, Stoltenberg SF, Li S, Gleiberman L, Chakravarti A, Weder AB, Burmeister M: A BDNF coding variant is associated with the NEO personality inventory domain neuroticism, a risk factor for depression. Neuropsychopharmacology. 2003, 28: 397-401. 10.1038/sj.npp.1300053.CrossRefPubMed
Metadata
Title
BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders
Authors
Victoria Arija
Marta Ferrer-Barcala
Nuria Aranda
Josepa Canals
Publication date
01-12-2010
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2010
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-10-363

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