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Langenbeck's Archives of Surgery

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01-08-2016 | ORIGINAL ARTICLE

Baseline mortality-adjusted survival in colon cancer patients

Authors: Kristjan Ukegjini, Marcel Zadnikar, Rene Warschkow, Sascha Müller, Bruno M. Schmied, Lukas Marti

Published in: Langenbeck's Archives of Surgery | Issue 5/2016

Abstract

Background

This investigation assessed the baseline mortality-adjusted survival after colon cancer resection.

Material and methods

In total, 523 patients with adenocarcinoma of the colon who underwent primary colon resection at Kantonsspital St. Gallen, Switzerland, between 1996 and 2008 were included.

Results

The median follow-up was 25 months for all patients and 39 months for those who survived until the end of the follow-up. The 5-year relative survival rate was 63.2 % (95 % CI 57.3–69.6 %), and the overall survival rate was 52 % (95 % CI 47.6–57.7 %). After curative resection of stage I–III colon cancer, 40 % of the observed deaths were cancer-related and 60 % reflected the baseline mortality. In stage I, the 5-year relative survival was 103.2 % (95 % CI 91.4–116.5 %) and was not different from a matched population (p = 0.820). In multivariate analysis, good general health and less advanced cancer stages were associated with better relative and overall survival rates. A more advanced age was associated with better relative survival, but worse overall survival.

Conclusions

The analysis of relative survival of patients exclusively with colon cancer revealed that prognosis of patients suffering from stage I colon cancer does not differ significantly from that of the general population. In more advanced stages, a relevant fraction of deaths is not cancer-related. As the stage determines a patient’s survival, early diagnosis is crucial for prognosis.

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Title: Baseline mortality-adjusted survival in colon cancer patients
Authors: Kristjan Ukegjini
Marcel Zadnikar
Rene Warschkow
Sascha Müller
Bruno M. Schmied
Lukas Marti
Publication date: 01-08-2016
Publisher: Springer Berlin Heidelberg
Published in: Langenbeck's Archives of Surgery / Issue 5/2016
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-016-1432-1

At a glance: The STEP trials

Springer Medicine

Baseline mortality-adjusted survival in colon cancer patients

Abstract

Background

Material and methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Material and methods

Results

Conclusions

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