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American Journal of Clinical Dermatology

Published in:

09-02-2023 | Bariatric Surgery | Systematic Review

Effects of Exercise and Dietary Modifications on Hidradenitis Suppurativa: A Systematic Review

Authors: Isaac Weber, Josie Giefer, Kari L. Martin

Published in: American Journal of Clinical Dermatology | Issue 3/2023

Abstract

Background

Hidradenitis suppurativa affects up to 4% of the population worldwide. Many treatment options exist but these come with a significant side-effect profile. Exercise, weight loss, and dietary modifications may be simple inexpensive alternatives and/or adjuncts to treating this disease.

Objectives

We aimed to summarize published evidence on the effects of dietary, weight loss, and exercise interventions on the clinical course, severity, or subjective improvement of hidradenitis suppurativa and to provide a framework regarding dietary changes and exercise modalities for clinicians treating this disease.

Methods

A literature search of Scopus (1993 onwards), PubMed (1986 onwards), and MEDLINE (OVID interface, 1946 onwards) was conducted on 22 October, 2022. Case–control studies, cohort studies, and randomized controlled trials with five or more subjects conducted on adult participants (aged >18 years) were included; case reports, case series, and review papers were excluded.

Results

Fifteen studies involving 2829 patients were included, encompassing nine cohort studies, five cross-sectional studies, and one cross-over study. Patients who were female, lost more than 50 pounds (22.7 kg), or were obese prior to weight loss saw improvement in hidradenitis suppurativa severity with weight loss. There was evidence for beneficial effects of diets, such as the Mediterranean diet that minimizes sugar, highly processed carbohydrates, and dairy, and emphasizes chicken, fruits, and vegetables, in patients with hidradenitis suppurativa. Evidence also supported benefit from oral zinc and vitamin D supplementation.

Conclusions

More evidence is needed in the form of randomized controlled trials or well-designed controlled trials to evaluate the effect of exercise and dietary manipulation on the hidradenitis suppurativa disease course. Overall, there is significant but weak evidence to support improvement in hidradenitis suppurativa severity with weight loss, dietary changes, and micronutrient supplementation. There is no significant evidence to support improvement in hidradenitis suppurativa symptomology with any type of exercise intervention.

Clinical Trial Registration

This protocol was registered with PROSPERO with the registration number CRD4202235099.

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Title: Effects of Exercise and Dietary Modifications on Hidradenitis Suppurativa: A Systematic Review
Authors: Isaac Weber
Josie Giefer
Kari L. Martin
Publication date: 09-02-2023
Publisher: Springer International Publishing
Keywords: Bariatric Surgery
Bariatric Surgery
Acne Inversa
Published in: American Journal of Clinical Dermatology / Issue 3/2023
Print ISSN: 1175-0561
Electronic ISSN: 1179-1888
DOI: https://doi.org/10.1007/s40257-023-00756-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Effects of Exercise and Dietary Modifications on Hidradenitis Suppurativa: A Systematic Review

Abstract

Background

Objectives

Methods

Results

Conclusions

Clinical Trial Registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objectives

Methods

Results

Conclusions

Clinical Trial Registration

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