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Obesity Surgery
Published in: Obesity Surgery 7/2019

Open Access 01-07-2019 | Bariatric Surgery | Original Contributions

Comparison of Meal Pattern and Postprandial Glucose Response in Duodenal Switch and Gastric Bypass Patients

Authors: Inger Nilsen, Magnus Sundbom, Niclas Abrahamsson, Arvo Haenni

Published in: Obesity Surgery | Issue 7/2019

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Abstract

Background

Bariatric surgery improves glucose homeostasis; however, side effects such as hypoglycemia can occur. We investigated the effects of meals on interstitial glucose (IG) response in biliopancreatic diversion with duodenal switch (BPD-DS) and Roux-en-Y gastric bypass (RYGBP)-operated patients at least 1 year after surgery.

Methods

Thirty patients treated with BPD-DS or RYGBP were recruited at the outpatient Obesity Unit, Uppsala University Hospital. IG was measured by continuous glucose monitoring (CGM) for 3 consecutive days, and postprandial IG levels from 5 to 120 min were analyzed for 2 of these days. All intake of food and beverages was simultaneously registered in a food diary, which was processed using The Meal Pattern Questionnaire.

Results

Postprandial IG levels were significantly lower in BPD-DS (n = 14) compared to RYGBP (n = 15)-treated patients, with mean concentrations of 5.0 (± 1.0) and 6.3 (± 1.8) mmol/L respectively (p < 0.001). The mean postprandial IG increment was lower in BPD-DS than in RYGBP patients, 0.2 (± 0.6) vs. 0.4 (± 1.4) mmol/L (p < 0.001). Furthermore, the postprandial IG variability was less pronounced in BPD-DS than in RYGBP patients. The mean number of daily meals did not differ between the two groups, 7.8 (± 2.6) in BPD-DS and 7.2 (± 1.7) in the RYGBP (p = 0.56).

Conclusion

BPD-DS patients demonstrated lower postprandial IG concentrations, with smaller postprandial IG increments and less pronounced postprandial IG variability compared to RYGBP patients. The two groups had similar meal pattern and the postprandial IG responses is probably associated with differences in postoperative physiology.
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Metadata
Title
Comparison of Meal Pattern and Postprandial Glucose Response in Duodenal Switch and Gastric Bypass Patients
Authors
Inger Nilsen
Magnus Sundbom
Niclas Abrahamsson
Arvo Haenni
Publication date
01-07-2019
Publisher
Springer US
Published in
Obesity Surgery / Issue 7/2019
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI
https://doi.org/10.1007/s11695-019-03826-3

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