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Published in: Critical Care 6/2011

01-12-2011 | Letter

Balanced study groups in a randomized trial - authors' response

Authors: Jan Benes, Ivan Chytra, Richard Pradl, Eduard Kasal

Published in: Critical Care | Issue 6/2011

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Excerpt

Thank you for giving us the chance to reply to the comment raised by Dr Munis [1]. As we wrote in the Materials and methods section of our article [2], we used a sealed envelope, simple randomization procedure in a 1:1 proportion of intervention to control. No stratification was performed, although there are some factors affecting the study group homogeneity. …
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go back to reference Benes J, Chytra I, Altmann P, Hluchy M, Kasal E, Svitak R, Pradl R, Stepan M: Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study. Crit Care 2010, 14: R118. 10.1186/cc9070PubMedCentralCrossRefPubMed Benes J, Chytra I, Altmann P, Hluchy M, Kasal E, Svitak R, Pradl R, Stepan M: Intraoperative fluid optimization using stroke volume variation in high risk surgical patients: results of prospective randomized study. Crit Care 2010, 14: R118. 10.1186/cc9070PubMedCentralCrossRefPubMed
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go back to reference Van der Linden PJ, Dierick A, Wilmin S, Bellens B, De Hert SG: A randomized controlled trial comparing an intraoperative goal-directed strategy with routine clinical practice in patients undergoing peripheral arterial surgery. Eur J Anaesthesiol 2010, 27: 788-793. 10.1097/EJA.0b013e32833cb2ddCrossRefPubMed Van der Linden PJ, Dierick A, Wilmin S, Bellens B, De Hert SG: A randomized controlled trial comparing an intraoperative goal-directed strategy with routine clinical practice in patients undergoing peripheral arterial surgery. Eur J Anaesthesiol 2010, 27: 788-793. 10.1097/EJA.0b013e32833cb2ddCrossRefPubMed
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go back to reference Boyd O, Grounds RM, Bennett ED: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993, 270: 2699-2707. 10.1001/jama.1993.03510220055034CrossRefPubMed Boyd O, Grounds RM, Bennett ED: A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 1993, 270: 2699-2707. 10.1001/jama.1993.03510220055034CrossRefPubMed
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go back to reference Mayer J, Boldt J, Mengistu A, Rohm K, Suttner S: Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial. Crit Care 2010, 14: R18. 10.1186/cc8875PubMedCentralCrossRefPubMed Mayer J, Boldt J, Mengistu A, Rohm K, Suttner S: Goal-directed intraoperative therapy based on autocalibrated arterial pressure waveform analysis reduces hospital stay in high-risk surgical patients: a randomized, controlled trial. Crit Care 2010, 14: R18. 10.1186/cc8875PubMedCentralCrossRefPubMed
Metadata
Title
Balanced study groups in a randomized trial - authors' response
Authors
Jan Benes
Ivan Chytra
Richard Pradl
Eduard Kasal
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10549

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