01-10-2015 | Review
B-type natriuretic peptide as a parameter for pulmonary hypertension in children. A systematic review
Published in: European Journal of Pediatrics | Issue 10/2015
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What is known:
• Pulmonary hypertension is a life-threatening disease. Diagnosis can be challenging in children; the current diagnostic options—right heart catheterization and echocardiography—are invasive and/or investigator-dependent procedures. • Biomarkers could be useful in this context because they are investigator independent and easy to obtain through blood samples. Brain natriuretic peptide (BNP) and its N-terminal cleavage product (NT-proBNP) seem to be the most promising. The value of these biomarkers in the diagnostic approach of PH has already been investigated in adults, with promising results. Pediatric studies are still scarce. |
What is new:
• The levels of BNP and NT-proBNP in pediatric patients differ strongly between the different categories of PH. Within the same category, the levels are more or less equal. • The relative changes could render them a prognostic marker in the follow-up of a certain individual patient. At this moment there is not enough evidence to rely on BNP or NT-proBNP in clinical treatment of patients with PH. |