Published in:
01-12-2003 | Adis Drug Profile
Azelnidipine
A Viewpoint by Yukihito Higashi
Author:
Yukihito Higashi
Published in:
Drugs
|
Issue 23/2003
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Excerpt
Azelnidipine is a new dihydropyridine calcium channel antagonist that is selective for L-type calcium channels. In patients with hypertension, a single dose of orally administered azelnidipine 8mg reaches peak plasma concentrations at 3.7 hours and has a plasma half-life of about 6 hours. This drug has a slow and persistent hypotensive effect, and does not affect the circadian rhythm of blood pressure. Azelnidipine, like amlodipine, is a third-generation dihydropyridine calcium antagonist. …