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Diabetology & Metabolic Syndrome
Published in: Diabetology & Metabolic Syndrome 1/2015

Open Access 01-12-2015 | Letter to the Editor

Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study)

Authors: Kazuhito Tawaramoto, Hideaki Kaneto, Mitsuru Hashiramoto, Fumiko Kawasaki, Fuminori Tatsumi, Masashi Shimoda, Shinji Kamei, Michihiro Matsuki, Tomoatsu Mune, Kohei Kaku

Published in: Diabetology & Metabolic Syndrome | Issue 1/2015

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Abstract

To evaluate the efficacy of azelnidipine and amlodipine on diabetic nephropathy and atherosclerosis, we designed a prospective and randomized controlled clinical study in type 2 diabetic patients with stable glycemic control with fixed dose of anti-diabetic medication. Although there was no difference in blood pressure between both groups, urinary albumin excretion and maximum carotid intima-media thickness were reduced in azelnidipine group, but not in amlodipine group. In addition, inflammatory cytokine levels were decreased only in azelnidipine group which possibly explains such beneficial effects of azelnidipine on urinary albumin excretion and carotid atherosclerosis.
Literature
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Adler AI, Stratton IM, Neil HA, Yudkin JS, Matthews DR, Cull CA, Wright AD, Turner RC, Holman RR. Association of systolic blood pressure with macrovascular and microvascular complications of type 2 diabetes. (UKPDS36): prospective observational study. BMJ. 2000;321:412–9.PubMedCentralCrossRefPubMed
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Parati G, Bilo G, Ochoa JE. Benefits of tight blood pressure control in diabetic patients with hypertension. Importance of early and sustained implementation of effective treatment strategies. Diabetes Care. 2011;34:S297–303.PubMedCentralCrossRefPubMed
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Ogawa S, Mori T, Nako K, Ito S. Combination therapy with renin-angiotensins in system inhibitors and the calcium channel blocker azelnidipine decreases plasma inflammatory markers and urinary oxidative stress markers in patients with diabetic nephropathy. Hypertens Res. 2008;31:1147–55.CrossRefPubMed
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Miura R, Nakamura K, Miura D, Miura A, Kajiya M, Hisamatsu K, Nagase S, Morita H, Fukushima-Kusano K, Matsubara H, Ohe T, Ito H. Cytokine reducing effect of azelnidipine in human peripheral blood mononuclear cells. Biol Pharm Bull. 2010;33:1148–51.CrossRefPubMed
Metadata
Title
Azelnidipine, but not amlodipine, reduces urinary albumin excretion and carotid atherosclerosis in subjects with type 2 diabetes: blood pressure control with olmesartan and azelnidipine in Type 2 diabetes (BOAT2 study)
Authors
Kazuhito Tawaramoto
Hideaki Kaneto
Mitsuru Hashiramoto
Fumiko Kawasaki
Fuminori Tatsumi
Masashi Shimoda
Shinji Kamei
Michihiro Matsuki
Tomoatsu Mune
Kohei Kaku
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Diabetology & Metabolic Syndrome / Issue 1/2015
Electronic ISSN: 1758-5996
DOI
https://doi.org/10.1186/s13098-015-0073-9

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