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09-11-2023 | Editorial

Autophagy and extracellular vesicles in the liver endothelium: friends or foes?

Authors: Louise Biquard, Pierre-Emmanuel Rautou

Published in: Hepatology International | Issue 1/2024

Graphical Abstract

Role of autophagy in liver sinusoidal endothelial cells (LSECs) and their interaction with hepatic stellate cells (HSC). EndoMT endothelial to mesenchymal transition, EV extracellular vesicle, HSC hepatic stellate cells, LSECs liver sinusoidal endothelial cells, MVB multivesicular body, NO nitric oxide.

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Hammoutene A, Rautou PE. Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease. J Hepatol. 2019;70:1278–1291. https://doi.org/10.1016/j.jhep.2019.02.012CrossRefPubMed

Kostallari E, Valainathan S, Biquard L, Shah VH, Rautou PE. Role of extracellular vesicles in liver diseases and their therapeutic potential. Adv Drug Deliv Rev. 2021;175:113816. https://doi.org/10.1016/j.addr.2021.05.026CrossRefPubMedPubMedCentral

Chen T, Zhang Y, Zhang Y, Ning Z, Xu Q, Lin Y, et al. Autophagic degradation of MVBs in LSECs promotes aldosterone induced-HSCs activation. Hepatol Int. 2023. https://doi.org/10.1007/s12072-023-10559-0CrossRefPubMed

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Title: Autophagy and extracellular vesicles in the liver endothelium: friends or foes?
Authors: Louise Biquard
Pierre-Emmanuel Rautou
Publication date: 09-11-2023
Publisher: Springer India
Published in: Hepatology International / Issue 1/2024
Print ISSN: 1936-0533
Electronic ISSN: 1936-0541
DOI: https://doi.org/10.1007/s12072-023-10606-w

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