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01-06-2022 | Autologous Fat | Review

Ophthalmic Complications Following Facial Autologous Fat Graft Injection: A Systematic Review and Meta-Analysis

Authors: Hatan Mortada, Hadeel Seraj, Mustafa A. Alhamoud, Reema Saleh Alghoribi, Omar Saleh Alsuhaibani, Mohammed Saad Khoshhal, Omar Fouda Neel

Published in: Aesthetic Plastic Surgery | Issue 6/2022

Abstract

Introduction

With the recent increase in interest in using autologous fat (AF) filler injections to enhance aesthetic facial appearance, there is a noticeable increase in the complications such as vascular compromise and blindness. This systematic review and meta-analysis aimed to understand the symptomatology of ophthalmic complications related to AF facial injections for cosmetic purposes, their underlying causes, management options, and the final clinical outcomes.

Methods

This review was conducted according to the International Prospective Register of Systematic Reviews (PROSPERO) guidelines. In November 2021, we performed a systematic review of available literature using the following electronic databases: Cochrane, MEDLINE, and EMBASE. Our search was limited to the published studies between 2000 and 2021.

Results

A total of 1052 publications and 34 articles published were included. Twenty case reports, two case series, one prospective cohort study, and eleven retrospective studies were evaluated. The forehead was the most common single injection site (n = 196, 55.36%). The most common initial symptom was periorbital swelling (92.7%). The pooled prevalence of ophthalmic artery occlusion was 50.4% out of all AF injection-related complications. Regarding the management, most patients were managed conservatively (n = 278, 51.38%). Complete improvement was observed among 423 patients (80.57%).

Conclusion

Autologous facial fat injection is a minimally invasive procedure with a favorable safety profile in cosmetic applications. However, the common use of these injections in aesthetic surgery has resulted in a concomitant increase in devastating consequences, such as blindness. Therefore, a firm understanding of the potential complications of such interventions is essential.

Level of Evidence III

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Title: Ophthalmic Complications Following Facial Autologous Fat Graft Injection: A Systematic Review and Meta-Analysis
Authors: Hatan Mortada
Hadeel Seraj
Mustafa A. Alhamoud
Reema Saleh Alghoribi
Omar Saleh Alsuhaibani
Mohammed Saad Khoshhal
Omar Fouda Neel
Publication date: 01-06-2022
Publisher: Springer US
Keywords: Autologous Fat
Aesthetic Surgery
Injectable Filler
Ophthalmoparesis
Published in: Aesthetic Plastic Surgery / Issue 6/2022
Print ISSN: 0364-216X
Electronic ISSN: 1432-5241
DOI: https://doi.org/10.1007/s00266-022-02924-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ophthalmic Complications Following Facial Autologous Fat Graft Injection: A Systematic Review and Meta-Analysis

Abstract

Introduction

Methods

Results

Conclusion

Level of Evidence III

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusion

Level of Evidence III

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