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Child and Adolescent Psychiatry and Mental Health
Published in: Child and Adolescent Psychiatry and Mental Health 1/2019

Open Access 01-12-2019 | Autism Spectrum Disorder | Research article

Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy

Authors: Mitsuhiro Uratani, Toyosaku Ota, Junzo Iida, Kosuke Okazaki, Kazuhiko Yamamuro, Yoko Nakanishi, Naoko Kishimoto, Toshifumi Kishimoto

Published in: Child and Adolescent Psychiatry and Mental Health | Issue 1/2019

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Abstract

Background

Functional neuroimaging studies suggest that prefrontal cortex dysfunction is present in people with autism spectrum disorder (ASD). Near-infrared spectroscopy is a noninvasive optical tool for examining oxygenation and hemodynamic changes in the cerebral cortex by measuring changes in oxygenated hemoglobin.

Methods

Twelve drug-naïve male participants, aged 7–15 years and diagnosed with ASD according to DSM-5 criteria, and 12 age- and intelligence quotient (IQ)-matched healthy control males participated in the present study after giving informed consent. Relative concentrations of oxyhemoglobin were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel near-infrared spectroscopy.

Results

Oxyhemoglobin changes during the Stroop color-word task in the ASD group were significantly smaller than those in the control group at channels 12 and 13, located over the dorsolateral prefrontal cortex (FDR-corrected P: 0.0021–0.0063).

Conclusion

The results suggest that male children with ASD have reduced prefrontal hemodynamic responses, measured with near-infrared spectroscopy.
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Metadata
Title
Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy
Authors
Mitsuhiro Uratani
Toyosaku Ota
Junzo Iida
Kosuke Okazaki
Kazuhiko Yamamuro
Yoko Nakanishi
Naoko Kishimoto
Toshifumi Kishimoto
Publication date
01-12-2019
Publisher
BioMed Central
Published in
Child and Adolescent Psychiatry and Mental Health / Issue 1/2019
Electronic ISSN: 1753-2000
DOI
https://doi.org/10.1186/s13034-019-0289-9

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