Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Clinical Neuroradiology
Published in: Clinical Neuroradiology 4/2016

01-12-2016 | Original Article

Auditory Pathway Features Determined by DTI in Subjects with Unilateral Acoustic Neuroma

Authors: S. Kurtcan, A. Alkan, R. Kilicarslan, A.A. Bakan, H. Toprak, A. Aralasmak, F. Aksoy, A. Kocer

Published in: Clinical Neuroradiology | Issue 4/2016

Login to get access

Abstract

Purpose

In the studies concerning the pathology of the auditory pathway in the vestibulocochlear system, few use advanced neuroimaging applications of magnetic resonance imaging (MRI) such as diffusion tensor imaging (DTI). Those who did use reported DTI changes only at the lateral lemniscus and inferior colliculus level. The aim of our study was to determine diffusion changes in the bilateral auditory pathways of subjects with unilateral acoustic neuroma (AN) and compare them with healthy controls.

Material and Methods

A total of 15 subjects with unilateral AN along with 11 controls underwent routine MRI and DTI. Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values obtained from the lateral lemniscus, inferior colliculus, corpus geniculatum mediale, and Heschl’s gyrus of the auditory pathway were then compared.

Results

The subjects’ ADC values measured from the contralateral side were significantly higher at the lateral lemniscus, inferior colliculus, and corpus geniculatum mediale compared with those of the controls. Also, decreased FA values were noted at the inferior colliculus for both the contralateral and ipsilateral sides. The highest ADC values were detected in the inferior colliculus of the auditory pathway.

Conclusions

In the auditory pathway of subjects with AN, the contralateral side is more affected than the ipsilateral side, the most affected region being the inferior colliculus. DTI is an advanced neuroimaging technique that can be used to determine the presence of microstructural damage to the auditory pathway in subjects with AN, whereas conventional MRI is not sensitive enough to detect damage.
Literature
1.
Salzman KL, Davidson HC, Harnsberger HR, Glastonbury CM, Wiggins RH, Ellul S, Shelton C. Dumbbell schwannomas of the internal auditory canal. AJNR Am J Neuroradiol. 2001;22:1368–76.PubMed
2.
Arthurs BJ, Fairbanks RK, Demakas JJ, Lamoreaux WT, Giddings NA, Mackay AR, Cooke BS, Elaimy AL, Lee CM. A review of treatment modalities for vestibular schwannoma. Neurosurg Rev. 2011;34:265–77.CrossRefPubMed
3.
Fortnum H, O’Neill C, Taylor R, Lenthall R, Nikolopoulos T, Lightfoot G, O’Donoghue G, Mason S, Baguley D, Jones H, Mulvaney C. The role of magnetic resonance imaging in the identification of suspected acoustic neuroma: a systematic review of clinical and cost effectiveness and natural history. Health Technol Assess. 2009;13:1–154.CrossRef
4.
Suzuki M, Hashimoto S, Kano S, Okitsu T. Prevalence of acoustic neuroma associated with each configuration of pure tone audiogram in patients with asymmetric sensorineural hearing loss. Ann Otol Rhinol Laryngol. 2010;119:615–18.PubMed
5.
Day AS, Wang CT, Chen CN, Young YH. Correlating the cochleovestibular deficits with tumor size of acoustic neuroma. Acta Otolaryngol. 2008;128:756–60.CrossRefPubMed
6.
Mark AS, Seltzer S, Harnsberger HR. Sensorineural hearing loss: more than meets the eye? AJNR Am J Neuroradiol. 1993;14:37–45.PubMed
7.
Gebarski SS, Tucci DL, Telian SA. The cochlear nuclear complex: MR location and abnormalities. AJNR Am J Neuroradiol. 1993;14:1311–8.PubMed
8.
Welling DB, Glasscock ME, 3rd, Woods CI, Jackson CG. Acoustic neuroma: a cost-effective approach. Otolaryngol Head Neck Surg. 1990;103:364–70.CrossRefPubMed
9.
Chang Y, Lee SH, Lee YJ, Hwang MJ, Bae SJ, Kim MN, Lee J, Woo S, Lee H, Kang DS. Auditory neural pathway evaluation on sensorineural hearing loss using diffusion tensor imaging. Neuroreport. 2004;15:1699–703.CrossRefPubMed
10.
Lin Y, Wang J, Wu C, Wai Y, Yu J, Ng S. Diffusion tensor imaging of the auditory pathway in sensorineural hearing loss: changes in radial diffusivity and diffusion anisotropy. J Magn Reson Imaging. 2008;28:598–603.CrossRefPubMed
11.
Wu CM, Ng SH, Liu TC. Diffusion tensor imaging of the subcortical auditory tract in subjects with long-term unilateral sensorineural hearing loss. Audiol Neurootol. 2009;14:248–53.CrossRefPubMed
12.
Taiwo O, Galusha D, Tessier-Sherman B, Kirsche S, Cantley L, Slade MD, Cullen MR, Donoghue AM. Acoustic neuroma: potential risk factors and audiometric surveillance in the aluminium industry. Occup Environ Med. 2014;71:624–8.CrossRefPubMedPubMedCentral
13.
Lin D, Hegarty JL, Fischbein NJ, Jackler RK. The prevalence of “incidental” acoustic neuroma. Arch Otolaryngol Head Neck Surg. 2005;131:241–4.CrossRefPubMed
14.
Yoshiura T, Higano S, Rubio A, Shrier DA, Kwok WE, Iwanaga S, Numaguchi Y. Heschl and superior temporal gyri: low signal intensity of the cortex on T2-weighted MR images of the normal brain. Radiology. 2000;214:217–21.CrossRefPubMed
15.
16.
de Bode S, Sininger Y, Healy EW, Mathern GW, Zaidel E. Dichotic listening after cerebral hemispherectomy: methodological and theoretical observations. Neuropsychologia. 2007;45:2461–6.CrossRefPubMedPubMedCentral
17.
Khosla D, Ponton CW, Eggermont JJ, Kwong B, Don M, Vasama JP. Differential ear effects of profound unilateral deafness on the adult human central auditory system. J Assoc Res Otolaryngol. 2003;4:235–49.CrossRefPubMedPubMedCentral
18.
Langers DR, van Dijk, Backes WH. Lateralization, connectivity and plasticity in the human central auditory system. Neuroimage. 2005;28:490–9.
19.
Jäncke L, Wüstenberg T, Schulze K, Heinze HJ. Asymmetric hemodynamic responses of the human auditory cortex to monaural and binaural stimulation. Hear Res. 2002;170:166–78.CrossRefPubMed
20.
Lin Y, Wang J, Wu C, Wai Y, Yu J, Ng S. Diffusion tensor imaging of the auditory pathway in sensorineural hearing loss: changes in radial diffusivity and diffusion anisotropy. J Magn Reson Imaging. 2008;28:598–603.CrossRefPubMed
21.
Wu CM, Ng SH, Wang JJ, Liu TC. Diffusion tensor imaging of the subcortical auditory tract in subjects with congenital cochlear nerve deficiency. AJNR Am J Neuroradiol. 2009;30:1773–7.CrossRefPubMed
22.
Mukherjee P, Miller JH, Shimony JS, Philip JV, Nehra D, Snyder AZ, Conturo TE, Neil JJ, McKinstry RC. Diffusion-tensor MR imaging of gray and white matter development during normal human brain maturation. AJNR Am J Neuroradiol. 2002;23:1445–56.PubMed
23.
Nakayama N, Okumura A, Shinoda J, Yasokawa YT, Miwa K, Yoshimura SI, Iwama T. Evidence for white matter disruption in traumatic brain injury without macroscopic lesions. J Neurol Neurosurg Psychiatry. 2006;77:850–5.CrossRefPubMedPubMedCentral
24.
Lin YC, Wang CC, Wai YY, Wan YL, Ng SH, Chen YL, Liu HL, Wang JJ. Significant temporal evolution of diffusion anisotropy for evaluating early response to radiosurgery in patients with vestibular schwannoma: findings from functional diffusion maps. AJNR Am J Neuroradiol. 2010;31:269–74.CrossRefPubMed
25.
Anderson RA, Knight PL, Merzenich MM. The thalamocortical and corticothalamic connections of AI, AII, and the anterior auditory field (AAF) in the cat: evidence for two largely segregated systems of connections. J Comp Neurol. 1980;194:663–701.CrossRef
26.
Bruckner S, Rübsamen R. Binaural response characteristics in isofrequency sheets of the gerbil inferior colliculus. Hear Res. 1995;86:1–14.CrossRefPubMed
Metadata
Title
Auditory Pathway Features Determined by DTI in Subjects with Unilateral Acoustic Neuroma
Authors
S. Kurtcan
A. Alkan
R. Kilicarslan
A.A. Bakan
H. Toprak
A. Aralasmak
F. Aksoy
A. Kocer
Publication date
01-12-2016
Publisher
Springer Berlin Heidelberg
Published in
Clinical Neuroradiology / Issue 4/2016
Print ISSN: 1869-1439
Electronic ISSN: 1869-1447
DOI
https://doi.org/10.1007/s00062-015-0385-z

Other articles of this Issue 4/2016

Clinical Neuroradiology 4/2016 Go to the issue

Letter to the Editor

Early termination of THRILL, a prospective study of mechanical thrombectomy in patients with acute ischemic stroke ineligible for i.v. thrombolysis

Original Article

Chronic T2 Lesions in Multiple Sclerosis are Heterogeneous Regarding Phase MR Imaging

Original Article

Clinical Muscle Testing Compared with Whole-Body Magnetic Resonance Imaging in Facio-scapulo-humeral Muscular Dystrophy

Correspondence

Percutaneous use of a dual lumen Scepter XC balloon for embolization of a complex facial arteriovenous malformation: a technical report

Letter to the Editor

Response to “High-Resolution Vessel Wall MRI: Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis”

REVIEW ARTICLE

Physics, Techniques and Review of Neuroradiological Applications of Diffusion Kurtosis Imaging (DKI)