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01-08-2017 | Brief Report

Atypical thymic carcinoid manifesting with nephrotic-range proteinuria in a 7-year-old boy

Authors: Jolanta Soltysiak, Danuta Ostalska-Nowicka, Katarzyna Zaorska, Karolina Sterzyńska, Katarzyna Derwich, Jacek Zachwieja

Published in: Pediatric Nephrology | Issue 8/2017

Abstract

Background

Nephrotic-range proteinuria as a paraneoplastic syndrome (PNS) is an exceptional presentation, especially in children. It is usually associated with hematologic malignancies. Solid tumors are very rare causes of proteinuria.

Case-Diagnosis/Treatment

We present the case of a 7-year-old boy with an extremely rare atypical thymic carcinoid accompanied by nephrotic-range proteinuria as PNS. The kidney biopsy was consistent with minimal change disease (MCD). Tests for a neuroendocrine tumor were performed due to symptoms of hypercortisolemia and an elevated concentration of chromogranin A in the serum. The chest computed tomography revealed a tumor in the anterior mediastinum, which was diagnosed as an atypical thymic carcinoid. A complete resolution of the nephrotic-range proteinuria was observed within 1 week after the first thoracoscopic surgery, with almost complete reduction of the tumor mass.

Conclusions

This extremely rare case shows that MCD can occur as a PNS even in children. Nephrotic-range proteinuria can be a symptom of malignant solid tumor. This case highlights the possibility of secondary causes of MCD in children.

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Title: Atypical thymic carcinoid manifesting with nephrotic-range proteinuria in a 7-year-old boy
Authors: Jolanta Soltysiak
Danuta Ostalska-Nowicka
Katarzyna Zaorska
Karolina Sterzyńska
Katarzyna Derwich
Jacek Zachwieja
Publication date: 01-08-2017
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 8/2017
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-017-3685-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Atypical thymic carcinoid manifesting with nephrotic-range proteinuria in a 7-year-old boy

Abstract

Background

Case-Diagnosis/Treatment

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case-Diagnosis/Treatment

Conclusions

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