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Critical Care
Published in: Critical Care 6/2011

01-12-2011 | Letter

Atypical antipsychotics and delirium in critical care

Authors: Matt P Wise, Madhankumar Vijayakumar, Steve Bowden

Published in: Critical Care | Issue 6/2011

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Excerpt

Wan and colleagues recently reported a case series of patients with refractory delirium successfully treated with the atypical antipsychotic drug quetiapine. This class of medication is used infrequently by critical care physicians at present and offers a potentially useful treatment for a group of patients who are clinically challenging to manage. However, larger studies are required to evaluate both efficacy and adverse events in a critically ill population. …
Literature
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Wan RYY, Kasliwal M, McKenzie CA, Barrett NA: Quetiapine in refractory hyperactive and mixed intensive care delirium: a case series. Crit Care 2011, 15: R159. 10.1186/cc10294PubMedCentralCrossRefPubMed
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Mac Sweeney R, Barber V, Page V, Ely EW, Perkins GD, Young JD, McAuley DF, Intensive Care Foundation: A national survey of the management of delirium in UK intensive care units. QJM 2010, 103: 243-251. 10.1093/qjmed/hcp194CrossRefPubMed
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Conley RR, Kelly DL: Drug-drug interactions associated with second-generation antipsychotics: considerations for clinicians and patients. Psychopharmacol Bull 2007, 40: 77-97.PubMed
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Smith MA, McCoy R, Hamer-Maansson J, Brecher M: Rapid dose escalation with quetiapine: a pilot study. J Clin Psychopharmacol 2005, 25: 331-335. 10.1097/01.jcp.0000168486.14516.7cCrossRefPubMed
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Saïas T, Gallarda T: Paradoxical aggressive reactions to benzodiazepine use: a review. Encephale 2008, 34: 330-336. 10.1016/j.encep.2007.05.005CrossRefPubMed
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Novotny T, Florianova A, Ceskova E, Weislamplova M, Palensky V, Tomanova J, Sisakova M, Toman O, Spinar J: Monitoring of QT interval in patients treated with psychotropic drugs. Int J Cardiol 2007, 117: 329-332. 10.1016/j.ijcard.2006.04.087CrossRefPubMed
Metadata
Title
Atypical antipsychotics and delirium in critical care
Authors
Matt P Wise
Madhankumar Vijayakumar
Steve Bowden
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Critical Care / Issue 6/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc10493

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