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BMC Ophthalmology

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Open Access 01-12-2024 | Atropine | Research

The role of vasoactive intestinal peptide (VIP) in atropine-related inhibition of the progression of myopia

Authors: Ying Wang, Lan Li, Xiaoli Tang, Haobo Fan, Weiqi Song, Juan Xie, Yangyu Tang, Yanqing Jiang, Yunchun Zou

Published in: BMC Ophthalmology | Issue 1/2024

Abstract

Objective

This study aimed to investigate the potential involvement of vasoactive intestinal polypeptide (VIP) in myopia development and its contribution to the mechanism of action of the anti-myopia drug, atropine.

Methods

Thirty-three-week-old guinea pigs were randomly divided into normal control (NC, n = 10), monocularly form-deprived (FDM, n = 10), and FDM treated with 1% atropine (FDM + AT, n = 10) groups. The diopter and axial length were measured at 0, 2, and 4 weeks. Guinea pig eyeballs were removed at week four, fixed, and stained for morphological changes. Immunohistochemistry (IHC) and in situ hybridization (ISH) were performed to evaluate VIP protein and mRNA levels.

Results

The FDM group showed an apparent myopic shift compared to the control group. The results of the H&E staining were as follows: the cells of the inner/outer nuclear layers and retinal ganglion cells were disorganized; the choroidal thickness (ChT), blood vessel lumen, and area were decreased; the sclera was thinner, with disordered fibers and increased interfibrillar space. IHC and ISH revealed that VIP's mRNA and protein expressions were significantly up-regulated in the retina of the FDM group. Atropine treatment attenuated FDM-induced myopic shift and fundus changes, considerably reducing VIP's mRNA and protein expressions.

Conclusions

The findings of elevated VIP mRNA and protein levels observed in the FDM group indicate the potential involvement of VIP in the pathogenesis and progression of myopia. The ability of atropine to reduce this phenomenon suggests that this may be one of the molecular mechanisms for atropine to control myopia.

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Title: The role of vasoactive intestinal peptide (VIP) in atropine-related inhibition of the progression of myopia
Authors: Ying Wang
Lan Li
Xiaoli Tang
Haobo Fan
Weiqi Song
Juan Xie
Yangyu Tang
Yanqing Jiang
Yunchun Zou
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Atropine
Published in: BMC Ophthalmology / Issue 1/2024
Electronic ISSN: 1471-2415
DOI: https://doi.org/10.1186/s12886-024-03309-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The role of vasoactive intestinal peptide (VIP) in atropine-related inhibition of the progression of myopia

Abstract

Objective

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusions

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