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Open Access 01-12-2023 | Atrial Fibrillation | Research article

The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort

Authors: Shunming Zhang, Anna Stubbendorff, Ulrika Ericson, Per Wändell, Kaijun Niu, Lu Qi, Yan Borné, Emily Sonestedt

Published in: BMC Medicine | Issue 1/2023

Abstract

Background

The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of the EAT-Lancet diet with the risk of incident AF and examine the interaction between the EAT-Lancet diet and genetic susceptibility of AF.

Methods

This prospective study included 24,713 Swedish adults who were free of AF, coronary events, and stroke at baseline. Dietary habits were estimated with a modified diet history method, and an EAT-Lancet diet index was constructed to measure the EAT-Lancet reference diet. A weighted genetic risk score was constructed using 134 variants associated with AF. Cox proportional hazards regression models were applied to estimate the hazard ratio (HR) and 95% confidence interval (CI).

Results

During a median follow-up of 22.9 years, 4617 (18.7%) participants were diagnosed with AF. The multivariable HR (95% CI) of AF for the highest versus the lowest group for the EAT-Lancet diet index was 0.84 (0.73, 0.98) (P for trend < 0.01). The HR (95% CI) of AF per one SD increment of the EAT-Lancet diet index for high genetic risk was 0.92 (0.87, 0.98) (P for interaction = 0.15).

Conclusions

Greater adherence to the EAT-Lancet diet index was significantly associated with a lower risk of incident AF. Such association tended to be stronger in participants with higher genetic risk, though gene-diet interaction was not significant.

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Title: The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort
Authors: Shunming Zhang
Anna Stubbendorff
Ulrika Ericson
Per Wändell
Kaijun Niu
Lu Qi
Yan Borné
Emily Sonestedt
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: Atrial Fibrillation
Published in: BMC Medicine / Issue 1/2023
Electronic ISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-023-02985-6

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The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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