Skip to main content
Top
Published in: General Thoracic and Cardiovascular Surgery 7/2021

01-07-2021 | Atrial Fibrillation | Review Article

Surgical considerations for atrial functional regurgitation of the mitral and tricuspid valves based on the etiological mechanism

Authors: Toshihiko Shibata, Yosuke Takahashi, Hiromichi Fujii, Akimasa Morisaki, Yukio Abe

Published in: General Thoracic and Cardiovascular Surgery | Issue 7/2021

Login to get access

Abstract

Atrial functional mitral regurgitation is a hot research topic in the field of mitral valve disease. Atrial functional mitral regurgitation is distinctly different from ventricular functional mitral regurgitation. The surgical indications for atrial functional mitral regurgitation have not been well established because of the small amount of evidence gathered to date. Mitral annular plication with an artificial ring is an essential surgical procedure because dilatation of the mitral valve annulus is a main factor underlying this pathology. Most of these cases can be treated by mitral annuloplasty alone. However, additional procedures, such as application of artificial chordae to the anterior leaflet for pseudo-prolapse, and posterior leaflet augmentation with a pericardial patch, are required in advanced cases with a giant left atrium and extremely enlarged mitral annulus. Chronic atrial fibrillation causes enlargement of the right and left atria. This pathology is a bilateral atrioventricular valve disease (dual-valve disease). Therefore, the conventional guidelines of single-valve disease should not be applied. Although atrial functional tricuspid regurgitation is underappreciated, tricuspid annuloplasty should be considered for most patients to prevent future regurgitation. In addition to the mitral and tricuspid valve procedure, integrated surgical management, including plication of the atrium and left appendage closure, is required. This review summarizes the current considerations of surgical treatment for atrial functional regurgitation of the mitral and tricuspid valves based on the etiological mechanism.
Literature
1.
go back to reference Otsuji Y, Kumanohoso T, Yoshihuku S, Matsukida K, Koriyama C, Kisanuki A, et al. Isolated annular dilatation does not usually cause important function mitral regurgitation. J Am Coll Cardiol. 2002;30:1651–6.CrossRef Otsuji Y, Kumanohoso T, Yoshihuku S, Matsukida K, Koriyama C, Kisanuki A, et al. Isolated annular dilatation does not usually cause important function mitral regurgitation. J Am Coll Cardiol. 2002;30:1651–6.CrossRef
2.
go back to reference Kihara T, Gillinov AM, Takasaki K, Fukuda S, Hong JM, Shiota M, et al. Mitral regurgitation associated with mitral annular dilation in patients with lone atrial fibrillation: an echocardiographic study. Echocardiography. 2009;26:885–9.CrossRef Kihara T, Gillinov AM, Takasaki K, Fukuda S, Hong JM, Shiota M, et al. Mitral regurgitation associated with mitral annular dilation in patients with lone atrial fibrillation: an echocardiographic study. Echocardiography. 2009;26:885–9.CrossRef
3.
go back to reference Gertz ZM, Raina A, Saghy L, Zado ES, Callans DJ, Marchlinsk FE, et al. Evidence of atrial functional mitral regurgitation due to atrial fibrillation: reversal with arrhythmia control. J Am Coll Cardiol. 2011;58:1474–81.CrossRef Gertz ZM, Raina A, Saghy L, Zado ES, Callans DJ, Marchlinsk FE, et al. Evidence of atrial functional mitral regurgitation due to atrial fibrillation: reversal with arrhythmia control. J Am Coll Cardiol. 2011;58:1474–81.CrossRef
4.
go back to reference Abe Y, Akamatsu K, Ito K, Matsumura Y, Shimeno K, Naruko T, et al. Prevalence and prognostic significance of functional mitral and tricuspid regurgitation despite preserved left ventricular ejection fraction in atrial fibrillation patients. Circ J. 2018;82:1451–8.CrossRef Abe Y, Akamatsu K, Ito K, Matsumura Y, Shimeno K, Naruko T, et al. Prevalence and prognostic significance of functional mitral and tricuspid regurgitation despite preserved left ventricular ejection fraction in atrial fibrillation patients. Circ J. 2018;82:1451–8.CrossRef
5.
go back to reference Ring L, Dutka DP, Wells FC, Fynn SP, Shapiro LM, Rana BS. Mechanisms of atrial mitral regurgitation: insights using 3D transoesophageal echo. Eur Heart J Cardiovasc Imaging. 2014;15:500–8.CrossRef Ring L, Dutka DP, Wells FC, Fynn SP, Shapiro LM, Rana BS. Mechanisms of atrial mitral regurgitation: insights using 3D transoesophageal echo. Eur Heart J Cardiovasc Imaging. 2014;15:500–8.CrossRef
6.
go back to reference Itabashi Y, Mihara H, Berdejo J, Utsunomiya H, Shiota T. Distant position of chordae from coaptation causes mitral regurgitation in patients with atrial fibrillation. J Heart Valve Dis. 2016;25:323–31.PubMed Itabashi Y, Mihara H, Berdejo J, Utsunomiya H, Shiota T. Distant position of chordae from coaptation causes mitral regurgitation in patients with atrial fibrillation. J Heart Valve Dis. 2016;25:323–31.PubMed
7.
go back to reference Machino-Ohtsuka T, Seo Y, Ishizu T, Sato K, Sugano A, Yamamoto M, et al. Novel mechanistic insights into atrial functional mitral regurgitation: 3-dimensional echocardiographic study. Circ J. 2016;80:2240–8.CrossRef Machino-Ohtsuka T, Seo Y, Ishizu T, Sato K, Sugano A, Yamamoto M, et al. Novel mechanistic insights into atrial functional mitral regurgitation: 3-dimensional echocardiographic study. Circ J. 2016;80:2240–8.CrossRef
8.
go back to reference Kagiyama N, Hayashida A, Toki M, Fukuda S, Ohara M, Hirohata A, et al. Insufficient leaflet remodeling in patients with atrial fibrillation: association with the severity of mitral regurgitation. Circ Cardiovasc Imaging. 2017;10:005451.CrossRef Kagiyama N, Hayashida A, Toki M, Fukuda S, Ohara M, Hirohata A, et al. Insufficient leaflet remodeling in patients with atrial fibrillation: association with the severity of mitral regurgitation. Circ Cardiovasc Imaging. 2017;10:005451.CrossRef
10.
go back to reference Akamatsu K, Abe Y, Matsumura Y, Shimeno K, Naruko T, Takahashi Y, et al. Etiology of atrial functional mitral regurgitation: Insights from transthoracic echocardiography in 159 consecutive patients with atrial fibrillation and preserved left ventricular ejection fraction. Cardiology. 2020. https://doi.org/10.1159/000508279.CrossRefPubMed Akamatsu K, Abe Y, Matsumura Y, Shimeno K, Naruko T, Takahashi Y, et al. Etiology of atrial functional mitral regurgitation: Insights from transthoracic echocardiography in 159 consecutive patients with atrial fibrillation and preserved left ventricular ejection fraction. Cardiology. 2020. https://​doi.​org/​10.​1159/​000508279.CrossRefPubMed
12.
go back to reference Angelini A, Ho SE, Anderson RH, Davies MJ, Becker AE. A histological study of the atrioventricular junction in hearts with normal and prolapsed leaflets of the mitral valve. Br Heart J. 1998;59:712–6.CrossRef Angelini A, Ho SE, Anderson RH, Davies MJ, Becker AE. A histological study of the atrioventricular junction in hearts with normal and prolapsed leaflets of the mitral valve. Br Heart J. 1998;59:712–6.CrossRef
13.
go back to reference Konda T, Tani T, Sunagawa N, Nakamura H, Sumida T, Fujii Y, et al. The analysis of mitral annular disjunction detected by echocardiography and comparison with previous pathological data. J Echocardiogr. 2017;15:176–85.CrossRef Konda T, Tani T, Sunagawa N, Nakamura H, Sumida T, Fujii Y, et al. The analysis of mitral annular disjunction detected by echocardiography and comparison with previous pathological data. J Echocardiogr. 2017;15:176–85.CrossRef
14.
go back to reference Abe Y, Takahashi Y, Shibata T. Functional mitral regurgitation, update: ventricular or atrial ? J Echocardiogr. 2020;18:1–8.CrossRef Abe Y, Takahashi Y, Shibata T. Functional mitral regurgitation, update: ventricular or atrial ? J Echocardiogr. 2020;18:1–8.CrossRef
15.
go back to reference Saito C, Minami Y, Arai K, Haruki S, Yagishita Y, Jujo K, et al. Prevalence, clinical characteristics, and outcome of atrial functional mitral regurgitation in hospitalized heart failure patients with atrial fibrillation. J Cardiol. 2018;72:292–9.CrossRef Saito C, Minami Y, Arai K, Haruki S, Yagishita Y, Jujo K, et al. Prevalence, clinical characteristics, and outcome of atrial functional mitral regurgitation in hospitalized heart failure patients with atrial fibrillation. J Cardiol. 2018;72:292–9.CrossRef
16.
go back to reference Deferm S, Bertrand P, Verugge FH, Verhaert D, Rega F, Thomas JD, et al. Atrial functional mitral regurgitation. JACC review topic of the week. J Am Coll Cardiol. 2019;73:2465–76.CrossRef Deferm S, Bertrand P, Verugge FH, Verhaert D, Rega F, Thomas JD, et al. Atrial functional mitral regurgitation. JACC review topic of the week. J Am Coll Cardiol. 2019;73:2465–76.CrossRef
17.
go back to reference Muraru D, Guta AC, Ochoa-Jimenez RC, Bartos D, Aruta P, Mihaila S, et al. Functional regurgitation of atrioventricular valves and atrial fibrillation: an elusive pathophysiological link deserving further attention. J Am Soc Echocardiol. 2020;33:42–53.CrossRef Muraru D, Guta AC, Ochoa-Jimenez RC, Bartos D, Aruta P, Mihaila S, et al. Functional regurgitation of atrioventricular valves and atrial fibrillation: an elusive pathophysiological link deserving further attention. J Am Soc Echocardiol. 2020;33:42–53.CrossRef
18.
go back to reference Ito K, Abe Y, Takahashi Y, Shimada Y, Fukumoto H, Matsumura Y, et al. Mechanism of atrial functional mitral regurgitation in patients with atrial fibrillation: a study using three-dimensional transesophageal echocardiography. J Cardiol. 2017;70:584–90.CrossRef Ito K, Abe Y, Takahashi Y, Shimada Y, Fukumoto H, Matsumura Y, et al. Mechanism of atrial functional mitral regurgitation in patients with atrial fibrillation: a study using three-dimensional transesophageal echocardiography. J Cardiol. 2017;70:584–90.CrossRef
19.
go back to reference Kilic A, Schwartzman DS, Subramanian K, Zenati M. Severe functional mitral regurgitation arising from isolated annular dilatation. Ann Thorac Surg. 2010;90:1343–5.CrossRef Kilic A, Schwartzman DS, Subramanian K, Zenati M. Severe functional mitral regurgitation arising from isolated annular dilatation. Ann Thorac Surg. 2010;90:1343–5.CrossRef
20.
go back to reference Vohra HA, Whistance RN, Magan A, Sadeque SA, Livesey SA, et al. Mitral valve repair for severe mitral regurgitation secondary to lone atrial fibrillation. Eur J Cardiothorac Surg. 2012;42:634–7.CrossRef Vohra HA, Whistance RN, Magan A, Sadeque SA, Livesey SA, et al. Mitral valve repair for severe mitral regurgitation secondary to lone atrial fibrillation. Eur J Cardiothorac Surg. 2012;42:634–7.CrossRef
21.
go back to reference Takahashi Y, Abe Y, Sasaki Y, Bito Y, Morisaki A, Nishimura S, et al. Mitral valve repair for atrial functional mitral regurgitation in chronic atrial fibrillation patients. Interact Cardiovasc Thorac Surg. 2015;21:163–8.CrossRef Takahashi Y, Abe Y, Sasaki Y, Bito Y, Morisaki A, Nishimura S, et al. Mitral valve repair for atrial functional mitral regurgitation in chronic atrial fibrillation patients. Interact Cardiovasc Thorac Surg. 2015;21:163–8.CrossRef
22.
go back to reference Sakaguchi T, Totsugawa T, Orihashi K, Kihara K, Tamura K, Hiraoka A, et al. Mitral annuloplasty for atrial functional mitral regurgitation in patients with chronic atrial fibrillation. J Cardiac Surg. 2019;34:767–73.CrossRef Sakaguchi T, Totsugawa T, Orihashi K, Kihara K, Tamura K, Hiraoka A, et al. Mitral annuloplasty for atrial functional mitral regurgitation in patients with chronic atrial fibrillation. J Cardiac Surg. 2019;34:767–73.CrossRef
23.
go back to reference Takahashi Y, Abe Y, Murakami T, Fujii H, Morisaki A, Nishimura S, Sakon Y, et al. Mid-term results of valve repairs for atrial functional mitral and tricuspid regurgitations. Gen Thorac Cardiovasc Surg. 2020;68:467–76.CrossRef Takahashi Y, Abe Y, Murakami T, Fujii H, Morisaki A, Nishimura S, Sakon Y, et al. Mid-term results of valve repairs for atrial functional mitral and tricuspid regurgitations. Gen Thorac Cardiovasc Surg. 2020;68:467–76.CrossRef
25.
go back to reference Nazari S, Carli S, Salvi S, Banfi C, Aluffi A, Mourad Z, et al. Patterns of systolic stress distribution on mitral valve anterior leaflet choral apparatus. A structural mechanical theoretical analysis. J Cardiovasc Surg. 2000;41:193–202. Nazari S, Carli S, Salvi S, Banfi C, Aluffi A, Mourad Z, et al. Patterns of systolic stress distribution on mitral valve anterior leaflet choral apparatus. A structural mechanical theoretical analysis. J Cardiovasc Surg. 2000;41:193–202.
26.
go back to reference Shibata T. Loop technique for mitral valve repair. Gen Thorac Cardiovasc Surg. 2014;62:71–7.CrossRef Shibata T. Loop technique for mitral valve repair. Gen Thorac Cardiovasc Surg. 2014;62:71–7.CrossRef
28.
go back to reference Takahashi Y, Shibata T, Hattori K, Hattori K, Kato Y, Motoki M, et al. Extended posterior leaflet extension for mitral regurgitation in giant left atrium. J Heart Valve Dis. 2014;23:88–90.PubMed Takahashi Y, Shibata T, Hattori K, Hattori K, Kato Y, Motoki M, et al. Extended posterior leaflet extension for mitral regurgitation in giant left atrium. J Heart Valve Dis. 2014;23:88–90.PubMed
29.
go back to reference Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KY, et al. Mitral valve adaptation to isolated annular dilation: insights into the mechanism of atrial functional mitral regurgitation. J Am Coll Cardiol Imaging. 2019;12:665–77.CrossRef Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KY, et al. Mitral valve adaptation to isolated annular dilation: insights into the mechanism of atrial functional mitral regurgitation. J Am Coll Cardiol Imaging. 2019;12:665–77.CrossRef
30.
go back to reference Quinn RW, Wang L, Foster N, Pasrija C, Ghoreish M, Dawood M, et al. Long-term performance of flesh autologous pericardium for mitral valve leaflet repair. Ann Thorac Surg. 2020;109:36–42.CrossRef Quinn RW, Wang L, Foster N, Pasrija C, Ghoreish M, Dawood M, et al. Long-term performance of flesh autologous pericardium for mitral valve leaflet repair. Ann Thorac Surg. 2020;109:36–42.CrossRef
31.
go back to reference Shomura Y, Okada Y, Nasu M, Koyama T, Yuzaki M, Murashita T, et al. Late results of mitral valve repair with glutaraldehyde-treated autologous pericardium. Ann Thorac Surg. 2013;95:2000–6.CrossRef Shomura Y, Okada Y, Nasu M, Koyama T, Yuzaki M, Murashita T, et al. Late results of mitral valve repair with glutaraldehyde-treated autologous pericardium. Ann Thorac Surg. 2013;95:2000–6.CrossRef
32.
go back to reference Mihos CG, Pineda AM, Capoulade R, Santana OA. A systemic review of mitral valve repair with autologous pericardial leaflet augmentation for rheumatic mitral regurgitation. Ann Thorac Surg. 2016;102:1400–5.CrossRef Mihos CG, Pineda AM, Capoulade R, Santana OA. A systemic review of mitral valve repair with autologous pericardial leaflet augmentation for rheumatic mitral regurgitation. Ann Thorac Surg. 2016;102:1400–5.CrossRef
33.
go back to reference Fukunaga N, Matsuo T, Saji Y, Imai Y, Koyama T. Mitral valve stenosis progression due to severe calcification on glutaraldehyde-treated autologous pericardium: word of caution for an attractive repair technique. Ann Thorac Surg. 2015;99:2203–5.CrossRef Fukunaga N, Matsuo T, Saji Y, Imai Y, Koyama T. Mitral valve stenosis progression due to severe calcification on glutaraldehyde-treated autologous pericardium: word of caution for an attractive repair technique. Ann Thorac Surg. 2015;99:2203–5.CrossRef
34.
go back to reference Zhou X, Otsuji Y, Yoshifuku S, Yuasa T, Zhang H, Takasaki K, et al. Impact of atrial fibrillation on tricuspid and mitral annular dilatation and valvular regurgitation. Circ J. 2002;66:913–6.CrossRef Zhou X, Otsuji Y, Yoshifuku S, Yuasa T, Zhang H, Takasaki K, et al. Impact of atrial fibrillation on tricuspid and mitral annular dilatation and valvular regurgitation. Circ J. 2002;66:913–6.CrossRef
35.
go back to reference Silbiger JJ. Atrial functional tricuspid regurgitation: an underappreciated cause of secondary tricuspid regurgitation. Echocardiography. 2019;36:954–7.CrossRef Silbiger JJ. Atrial functional tricuspid regurgitation: an underappreciated cause of secondary tricuspid regurgitation. Echocardiography. 2019;36:954–7.CrossRef
36.
go back to reference Ito K, Abe Y, Watanabe H, Shimada Y, Shibayama K, Oe H, et al. Prognostic significance of residual functional mitral regurgitation in hospitalized heart failure patients with chronic atrial fibrillation and preserved ejection fraction after medical therapies. J Echocardiogr. 2019;17:197–205.CrossRef Ito K, Abe Y, Watanabe H, Shimada Y, Shibayama K, Oe H, et al. Prognostic significance of residual functional mitral regurgitation in hospitalized heart failure patients with chronic atrial fibrillation and preserved ejection fraction after medical therapies. J Echocardiogr. 2019;17:197–205.CrossRef
37.
go back to reference Kawazoe K, Beppu S, Takahara Y, Nakajima N, Tanaka K, Ichihashi K, et al. Surgical treatment of giant left atrium combined with mitral valvular disease. Plication procedure for reduction of compression to the left ventricle, bronchus, and pulmonary parenchyma. J Thorac Cardiovasc Surg. 1983;85:885–92.CrossRef Kawazoe K, Beppu S, Takahara Y, Nakajima N, Tanaka K, Ichihashi K, et al. Surgical treatment of giant left atrium combined with mitral valvular disease. Plication procedure for reduction of compression to the left ventricle, bronchus, and pulmonary parenchyma. J Thorac Cardiovasc Surg. 1983;85:885–92.CrossRef
39.
go back to reference Ohba M, Asano S, Ito T, Matuso K, Hayashida N, Murayama H, et al. Surgical repair for atrial functional mitral regurgitation. Am J Surg Case Rep. 2020;1:article 1002. Ohba M, Asano S, Ito T, Matuso K, Hayashida N, Murayama H, et al. Surgical repair for atrial functional mitral regurgitation. Am J Surg Case Rep. 2020;1:article 1002.
40.
go back to reference Nagaura T, Hayashi A, Yoshida J, Ikenaga H, Yamaguchi H, Rader F, et al. Percutaneous edge-to-edge repair for atrial functional mitral regurgitation. A real-time 3-dimensional transesophageal echocardiography study. JACC Cardiovasc Imaging. 2019;12:1881–3.CrossRef Nagaura T, Hayashi A, Yoshida J, Ikenaga H, Yamaguchi H, Rader F, et al. Percutaneous edge-to-edge repair for atrial functional mitral regurgitation. A real-time 3-dimensional transesophageal echocardiography study. JACC Cardiovasc Imaging. 2019;12:1881–3.CrossRef
Metadata
Title
Surgical considerations for atrial functional regurgitation of the mitral and tricuspid valves based on the etiological mechanism
Authors
Toshihiko Shibata
Yosuke Takahashi
Hiromichi Fujii
Akimasa Morisaki
Yukio Abe
Publication date
01-07-2021
Publisher
Springer Singapore
Published in
General Thoracic and Cardiovascular Surgery / Issue 7/2021
Print ISSN: 1863-6705
Electronic ISSN: 1863-6713
DOI
https://doi.org/10.1007/s11748-021-01629-x

Other articles of this Issue 7/2021

General Thoracic and Cardiovascular Surgery 7/2021 Go to the issue