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01-04-2022 | Atrial Fibrillation | Original Article

Clinical impact of perioperative atrial fibrillation on long-term recurrence of malignancy

Authors: Satoshi Higuchi, Yusuke Kabeya, Kenichi Matsushita, Keisei Tachibana, Riken Kawachi, Hidefumi Takei, Ryota Tanaka, Yutaka Suzuki, Yorihisa Imanishi, Shigeki Shibata, Hiroshi Hasegawa, Koichiro Saito, Kiyoshi Moriyama, Tomoko Yorozu, Nobutsugu Abe, Haruhiko Kondo, Takeaki Matsuda, Hideaki Yoshino

Published in: Heart and Vessels | Issue 4/2022

Abstract

Perioperative complications have been reported to be associated with a lower incidence of cancer-free survival. Perioperative atrial fibrillation (POAF) is one of occasionally observed complications in patients with malignancies who undergo noncardiac surgeries. However, the long-term clinical impact of POAF on those with malignancies have remained unknown. This was a prospective, single-center, observational study. Patients who underwent noncardiac surgeries for definitive malignancies between 2014 and 2017 were included. The primary and secondary endpoints were 3-year recurrence of malignancies and cancer death, respectively. The present study included consecutive 752 patients (mean age, 68 ± 11 years; males, 62%), and POAF was observed in 77 patients. The follow-up duration was 1037 (interquartile range, 699–1408) days. The 3-year recurrence of malignancies was observed in 239 (32%) patients (POAF, 32 [42%]; non-POAF, 207 [31%]) and 3-year mortality was 130 patients (17%). Cardiac, noncardiac, and cancer deaths were observed in 4 (0.5%), 126 (17%), and 111 (15%) patients, respectively. Multivariate Cox regression analysis demonstrated that POAF was associated with 3-year recurrence of malignancies (hazard ratio [HR], 1.70; 95% confidence interval [CI], 1.15–2.52). Landmark analysis demonstrated that POAF tended to be correlated with the incidence of 3-year cancer death (HR, 1.79; 95% CI, 0.96–3.31). In conclusion, POAF is associated with the subsequent recurrence of malignancies. The association of arrhythmia with cancer death may be revealed under longer follow-up durations.

Clinical Trial Registration: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018270. UMIN ID: UMIN000016146.

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Title: Clinical impact of perioperative atrial fibrillation on long-term recurrence of malignancy
Authors: Satoshi Higuchi
Yusuke Kabeya
Kenichi Matsushita
Keisei Tachibana
Riken Kawachi
Hidefumi Takei
Ryota Tanaka
Yutaka Suzuki
Yorihisa Imanishi
Shigeki Shibata
Hiroshi Hasegawa
Koichiro Saito
Kiyoshi Moriyama
Tomoko Yorozu
Nobutsugu Abe
Haruhiko Kondo
Takeaki Matsuda
Hideaki Yoshino
Publication date: 01-04-2022
Publisher: Springer Japan
Keyword: Atrial Fibrillation
Published in: Heart and Vessels / Issue 4/2022
Print ISSN: 0910-8327
Electronic ISSN: 1615-2573
DOI: https://doi.org/10.1007/s00380-021-01954-4

2024 ASCO Annual Meeting

Springer Medicine

Clinical impact of perioperative atrial fibrillation on long-term recurrence of malignancy

Abstract

2024 ASCO Annual Meeting

Springer Medicine

Abstract

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