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Journal of Cardiothoracic Surgery

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Open Access 01-12-2023 | Atrial Fibrillation | Research

Prognostic effect of atrial fibrillation on survival in patients with hypertrophic cardiomyopathy: a meta-analysis

Authors: Meiling Du, Xiaoyuan Wang, Aiai Zhang, Feixing Li, Mengyang Yi

Published in: Journal of Cardiothoracic Surgery | Issue 1/2023

Abstract

Objective

To systematically evaluate the prognostic impact of atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).

Methods

The Chinese and English databases (PubMed, EMBASE, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang database were systematically searched to include observational studies on the prognosis of AF in cardiovascular events or death in patients with HCM; these were evaluated using Revman 5.3.

Results

After systematic search and screening, a total of 11 studies with a high study quality were included in this study. Meta-analysis showed that patients with HCM accompanied by AF had a higher risk of all-cause death (odds ratio [OR] = 2.75; 95% confidence interval [CI]: 2.18–3.47; P < 0.001), heart-related death (OR = 2.62; 95%CI: 2.02–3.40; P < 0.001), sudden cardiac death (OR = 7.09; 95%CI: 5.77–8.70; P < 0.001), heart-failure-related death (OR = 2.04; 95%CI: 1.24–3.36; P = 0.005), and stroke death (OR = 17.05; 95%CI: 6.99–41.58; P < 0.001) compared with patients with HCM without AF.

Conclusion

Atrial fibrillation is a risk factor for adverse survival outcomes in patients with HCM, and aggressive interventions are needed in this population to avoid the occurrence of adverse outcomes.

Medical Masterclass contributors, Firth J. Cardiology: hypertrophic cardiomyopathy. Clin Med (Lond). 2019;19(1):61–3.CrossRef

Diagnosis and treatment of cardiomyopathy. Chin J Cardiol. 2007;35(01):5–16.

Camm CF, Camm AJ. Atrial fibrillation and anticoagulation in hypertrophic cardiomyopathy. Arrhythm Electrophysiol Rev. 2017;6(2):63–8.CrossRefPubMedPubMedCentral

Wang J. Diagnosis and treatment of premature ventricular contraction-induced cardiomyopathy. Adv Cardiovasc Dis. 2020;41(06):563–6.

Guttmann OP, Rahman MS, O’Mahony C, Anastasakis A, Elliott PM. Atrial fibrillation and thromboembolism in patients with hypertrophic cardiomyopathy: systematic review. Heart. 2014;100(6):465–72.CrossRefPubMed

Garg L, Gupta M, Sabzwari SRA, Agrawal S, Agarwal M, Nazir T, Gordon J, Bozorgnia B, Martinez MW. Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical impact, and management. Heart Fail Rev. 2019;24(2):189–97.CrossRefPubMed

Olivotto I, Cecchi F, Casey SA, Dolara A, Traverse JH, Maron BJ. Impact of atrial fibrillation on the clinical course of hypertrophic cardiomyopathy. Circulation. 2001;104(21):2517–24.CrossRefPubMed

Vermond RA, Geelhoed B, Verweij N, Tieleman RG, Van der Harst P, Hillege HL, Van Gilst WH, Van Gelder IC, Rienstra M. Incidence of Atrial Fibrillation and Relationship with Cardiovascular events, heart failure, and Mortality: A Community-Based study from the Netherlands. J Am Coll Cardiol. 2015;66(9):1000–7.CrossRefPubMed

Liao MT, Wu CK, Juang JJ, Lin TT, Wu CC, Lin LY. Atrial fibrillation and the risk of sudden cardiac arrest in patients with hypertrophic cardiomyopathy - A nationwide cohort study. EClinicalMedicine. 2021;34:100802.CrossRefPubMedPubMedCentral

10.

Robinson K, Frenneaux MP, Stockins B, Karatasakis G, Poloniecki JD, McKenna WJ. Atrial fibrillation in hypertrophic cardiomyopathy: a longitudinal study. J Am Coll Cardiol. 1990;15(6):1279–85.CrossRefPubMed

11.

Siontis KC, Geske JB, Ong K, Nishimura RA, Ommen SR, Gersh BJ. Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical correlations, and mortality in a large high-risk population. J Am Heart Assoc. 2014;3(3):e001002.CrossRefPubMedPubMedCentral

12.

Tian T, Wang Y, Sun K, Wang J, Zou Y, Zhang W, Bao J, Zhu L, Shen H, Hui R, Zhou X, Song L. Clinical profile and prognostic significance of atrial fibrillation in hypertrophic cardiomyopathy. Cardiology. 2013;126(4):258–64.CrossRefPubMed

13.

Maron BJ, Olivotto I, Spirito P, Casey SA, Bellone P, Gohman TE, Graham KJ, Burton DA, Cecchi F. Epidemiology of hypertrophic cardiomyopathy-related death: revisited in a large non-referral-based patient population. Circulation. 2000;102(8):858–64.CrossRefPubMed

14.

Lee SE, Park JK, Uhm JS, Kim JY, Pak HN, Lee MH, Joung B. Impact of atrial fibrillation on the clinical course of apical hypertrophic cardiomyopathy. Heart. 2017;103(19):1496–501.CrossRefPubMed

15.

Higashikawa M, Nakamura Y, Yoshida M, Kinoshita M. Incidence of ischemic strokes in hypertrophic cardiomyopathy is markedly increased if complicated by atrial fibrillation. Jpn Circ J. 1997;61(8):673–81.CrossRefPubMed

16.

Desai MY, Smedira NG, Bhonsale A, Thamilarasan M, Lytle BW, Lever HM. Symptom assessment and exercise impairment in surgical decision making in hypertrophic obstructive cardiomyopathy: relationship to outcomes. J Thorac Cardiovasc Surg. 2015;150(4):928–35.CrossRefPubMed

17.

Lee HJ, Kim HK, Kim M, Moon I, Lee H, Kim BS, Han KD, Park JB, Hwang IC, Yoon YE, Kim YJ, Cho GY, Ommen SR. Clinical impact of atrial fibrillation in a nationwide cohort of hypertrophic cardiomyopathy patients. Ann Transl Med. 2020;8(21):1386.CrossRefPubMedPubMedCentral

18.

Song YJ, Jiang TY, Ren XJ, Wang Y, Han ZH. Influence of atrial fibrillation on long-term prognosis of patients with hypertrophic cardiomyopathy. J Chin Practical Diagnosis Therapy. 2013;27(02):126–8.

19.

Cinar T, Hayiroğlu M, Çiçek V, Asal S, Atmaca MM, Keser N, Orhan AL. Predictors of left atrial thrombus in acute ischemic stroke patients without atrial fibrillation: A single-center cross-sectional study. Rev Assoc Med Bras (1992). 2020;66(10):1437-43.

20.

Kong Q, Shi L, Yu R, Long D, Zhang Y, Chen Y, Li J. Biatrial enlargement as a predictor for reablation of atrial fibrillation. Int J Med Sci. 2020;17(18):3031–8.CrossRefPubMedPubMedCentral

21.

MacIntyre C, Lakdawala NK. Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy. Circulation. 2016;133(19):1901–5.CrossRefPubMed

22.

Zou YB, Song L. Interpretation of 2017 guidelines for the diagnosis and treatment for chinese adult patients with hypertrophic cardiomyopathy. Mol Cardiol China. 2018;18(02):2396–400.

23.

Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, ESC Scientific Document Group. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016;37(38):2893–962.CrossRefPubMed

24.

Tuluce K, Yakar Tuluce S, Kahya Eren N, Kocabas U, Akyildiz Akcay F, Gunduz R, Akyildiz ZI, Ergene O. Predictors of Future Atrial Fibrillation Development in patients with hypertrophic cardiomyopathy: a prospective Follow-Up study. Echocardiography. 2016;33(3):379–85.CrossRefPubMed

25.

Fu XD. Abnormal blood uric acid metabolism and CYP11B2-344T > C gene polymorphism in hypertensive patients with atrial fibrillation[D]. Army Medical University; 2015.

26.

Gaita F, Di Donna P, Olivotto I, Scaglione M, Ferrero I, Montefusco A, Caponi D, Conte MR, Nistri S, Cecchi F. Usefulness and safety of transcatheter ablation of atrial fibrillation in patients with hypertrophic cardiomyopathy. Am J Cardiol. 2007;99(11):1575–81.CrossRefPubMed

Title: Prognostic effect of atrial fibrillation on survival in patients with hypertrophic cardiomyopathy: a meta-analysis
Authors: Meiling Du
Xiaoyuan Wang
Aiai Zhang
Feixing Li
Mengyang Yi
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Atrial Fibrillation
Cardiomyopathy
Sudden Cardiac Death
Stroke
Published in: Journal of Cardiothoracic Surgery / Issue 1/2023
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-023-02299-x

2024 ASCO Annual Meeting

Springer Medicine

Prognostic effect of atrial fibrillation on survival in patients with hypertrophic cardiomyopathy: a meta-analysis

Abstract

Objective

Methods

Results

Conclusion

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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