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European Journal of Medical Research

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Open Access 01-12-2023 | Atrial Fibrillation | Research

A real-world case–control study on the efficacy and safety of pulsed field ablation for atrial fibrillation

Authors: Ming Yang, Peng-yu Wang, Ying-lu Hao, Mei Liang, Zi-yang Yu, Xi-chen Li, Yan-ping Li

Published in: European Journal of Medical Research | Issue 1/2023

Abstract

Objective

The primary objective of this study was to evaluate the efficacy and safety of pulsed field ablation in individuals diagnosed with atrial fibrillation.

Methods

A total of 36 patients diagnosed with atrial fibrillation were enrolled in the pulsed field ablation group, while another 36 patients diagnosed with atrial fibrillation were included in the radiofrequency ablation group. Among the study participants, 15 patients in the pulsed field ablation group and 17 patients in the radiofrequency ablation group had persistent atrial fibrillation. Comprehensive comparisons were made between the two groups, including baseline data, underlying diseases, medication usage, intraoperative parameters, and atrial fibrillation recurrence rates at 1, 3, and 6 months during the postoperative follow-up period.

Results

(1) There were no significant differences observed between the two groups concerning baseline data and antiarrhythmic drug usage (P > 0.05); (2) the effective ablation time for both left and right pulmonary veins in the pulsed field ablation group was markedly shorter compared to the radiofrequency ablation group (P < 0.001 for each vein); (3) within the pulsed field ablation group, the number of discharges, catheter operation time, and effective ablation time for the left pulmonary vein were significantly higher than those for the right pulmonary vein (P < 0.05). Conversely, in the radiofrequency ablation group, the number of discharges for the left pulmonary vein was significantly higher than that for the right pulmonary vein (P < 0.05); and (4) when comparing sinus rhythm maintenance at 1, 3, and 6 months postoperatively, no statistically significant differences were noted between the two groups for paroxysmal, persistent, and paroxysmal + persistent atrial fibrillation cases (P > 0.05).

Conclusion

During the 6-month follow-up period, pulsed field ablation demonstrated comparable efficacy to radiofrequency ablation with respect to recurrence rates for both paroxysmal and persistent atrial fibrillation. Moreover, pulsed field ablation exhibited high safety levels, excellent surgical efficiency, and a notably brief learning curve, affirming its viability as a therapeutic option for these conditions.

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Title: A real-world case–control study on the efficacy and safety of pulsed field ablation for atrial fibrillation
Authors: Ming Yang
Peng-yu Wang
Ying-lu Hao
Mei Liang
Zi-yang Yu
Xi-chen Li
Yan-ping Li
Publication date: 01-12-2023
Publisher: BioMed Central
Keyword: Atrial Fibrillation
Published in: European Journal of Medical Research / Issue 1/2023
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/s40001-023-01509-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

A real-world case–control study on the efficacy and safety of pulsed field ablation for atrial fibrillation

Abstract

Objective

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Methods

Results

Conclusion

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