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Open Access 01-12-2017 | Commentary

Ataxia in children: think about vitamin E deficiency ! (comment on: ataxia in children: early recognition and clinical evaluation)

Authors: H. Rahmoune, N. Boutrid, M. Amrane, M. C. Chekkour, B. Bioud

Published in: Italian Journal of Pediatrics | Issue 1/2017

Abstract

A recent article from Pavone et al. published in the Italian Journal of Pediatrics entitled «Ataxia in children: early recognition and clinical evaluation» made an exhaustive overview of the large spectrum of pediatric ataxias.

However, we would underline the importance of considering hereditary ataxia due to isolated vitamin E deficiency as a specific and treatable cause of child ataxia.

We present a short clinical and therpeutic synopsis of this peculiar genetic etiology, frequently encountred in the mediterranean region.

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Jayadev S, Bird TD. Hereditary ataxias: overview. Genet Med. 2013;15:673–83.CrossRefPubMed

Shorer Z, Parvari R, Bril G, Sela BA, Moses S. Ataxia with isolated vitamin E deficiency in four siblings. Pediatr Neurol. 1996;15:340–3.CrossRefPubMed

Anheim M. Ataxia with vitamin E deficiency. 2013. Orphanet Database. http://www.orpha.net/consor/cgi-bin/OC_Exp.php?lng=EN&Expert=96. Accessed 16 Jan 2017.

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Mariotti C, Gellera C, Rimoldi M, Mineri R, Uziel G, Zorzi G, Pareyson D, Piccolo G, Gambi D, Piacentini S, Squitieri F, Capra R, Castellotti B, Di Donato S. Ataxia with isolated vitamin E deficiency: neurological phenotype, clinical followup and novel mutations in TTPA gene in Italian families. Neurol Sci. 2004;25:130–7.CrossRefPubMed

Title: Ataxia in children: think about vitamin E deficiency ! (comment on: ataxia in children: early recognition and clinical evaluation)
Authors: H. Rahmoune
N. Boutrid
M. Amrane
M. C. Chekkour
B. Bioud
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Italian Journal of Pediatrics / Issue 1/2017
Electronic ISSN: 1824-7288
DOI: https://doi.org/10.1186/s13052-017-0378-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Ataxia in children: think about vitamin E deficiency ! (comment on: ataxia in children: early recognition and clinical evaluation)

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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