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01-11-2003 | Original Article

Associations of polymorphisms in the vitamin D receptor gene (BsmI and FokI) with bone mineral density in postmenopausal women in Malta

Authors: C. Vidal, C. Grima, M. Brincat, N. Megally, A. Xuereb-Anastasi

Published in: Osteoporosis International | Issue 11/2003

Abstract

Previous studies have suggested that variations in the vitamin D receptor (VDR) gene are related to bone mineral density (BMD). In this study, the T→C transition in the start codon and the G→A polymorphism at the 3′ end of the VDR gene, identified by endonucleases FokI and BsmI, respectively, were analysed and correlated with BMD in postmenopausal Maltese women (n=104). Genotype frequencies observed for the VDR start codon polymorphism (SCP) were CC: 60.4%; CT: 30.7% and TT: 8.9%, while those observed for the 3′ in this study were GG: 16.4%; GA: 51.9%; AA: 31.7%. In postmenopausal women, both lumbar and femoral BMD were observed to be highest in CC homozygotes for the FokI genotype and in GG homozygotes for the BsmI genotype, although in both groups the difference between the genotypes was not statistically significant, even after adjusting BMD for age, BMI and years since menopause. No evidence of linkage disequilibrium between the two alleles was observed.

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Title: Associations of polymorphisms in the vitamin D receptor gene (BsmI and FokI) with bone mineral density in postmenopausal women in Malta
Authors: C. Vidal
C. Grima
M. Brincat
N. Megally
A. Xuereb-Anastasi
Publication date: 01-11-2003
Publisher: Springer-Verlag
Published in: Osteoporosis International / Issue 11/2003
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-003-1457-5

Keynote webinar | Spotlight on medication adherence

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Associations of polymorphisms in the vitamin D receptor gene (BsmI and FokI) with bone mineral density in postmenopausal women in Malta

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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