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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-01-2015 | Medical Ophthalmology

Associations of macular thickness in spectral-domain OCT with ocular and systemic cardiovascular parameters - The MIPH Eye & Health Study

Authors: Alexander Karl-Georg Schuster, Joachim Ernst Fischer, Urs Vossmerbaeumer

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 1/2015

Abstract

Purpose

Beyond in-vivo histological analysis of retinal tissue, optical coherence tomography (OCT) allows quantitative image analysis. This study evaluates associations of macular retinal thickness measured with spectral-domain OCT (SD-OCT) and ocular and systemic cardiovascular parameters in adult subjects.

Methods

An epidemiological cross-sectional study was performed in the staff of a European high-tech company. Examination of known cardiovascular risk factors including biochemical blood analysis was performed, and ocular parameters such as refraction, tonometry, SD-OCT imaging of the macula and cornea, and fundus photography were evaluated. Retinal thickness measurements were evaluated according to the ETDRS grid. Associations of macular retinal thickness and systemic cardiovascular and ocular parameters were calculated by multivariate analysis using SPSS software.

Results

Four hundred and twenty-four probands were included. Macular thickness measurement were significantly associated with gender and refraction. Female persons had thinner retinal thickness in all zones. Macular thickness decreased with increasing myopia in all perifoveal measurements. Outer perifoveal measurements were associated with keratometry; a flatter corneal radius was linked to a thinner retina. Tonometry and systemic cardiovascular risk factors were not associated with macular retinal thickness in multivariate analysis (p > 0.05).

Conclusions

Macular retinal thickness is associated with refraction and gender; cardiovascular risk factors or tonometry do not influence macular retinal thickness measurements. Keratometry might influence outer zone measurements. Our findings provide a dataset for quantitative evaluation of SD-OCT, and evaluate influencing factors.

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Title: Associations of macular thickness in spectral-domain OCT with ocular and systemic cardiovascular parameters - The MIPH Eye & Health Study
Authors: Alexander Karl-Georg Schuster
Joachim Ernst Fischer
Urs Vossmerbaeumer
Publication date: 01-01-2015
Publisher: Springer Berlin Heidelberg
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 1/2015
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-014-2781-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Associations of macular thickness in spectral-domain OCT with ocular and systemic cardiovascular parameters - The MIPH Eye & Health Study

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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