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BMC Psychiatry

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Open Access 01-12-2021 | Research

Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

Authors: Lan Guo, Wanxin Wang, Yangfeng Guo, Xueying Du, Guangduoji Shi, Ciyong Lu

Published in: BMC Psychiatry | Issue 1/2021

Abstract

Background

Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style.

Methods

This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis.

Results

In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13–5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11–5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms.

Conclusions

Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.

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Title: Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
Authors: Lan Guo
Wanxin Wang
Yangfeng Guo
Xueying Du
Guangduoji Shi
Ciyong Lu
Publication date: 01-12-2021
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2021
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-021-03576-6

2024 ASCO Annual Meeting

Springer Medicine

Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents

Abstract

Background

Methods

Results

Conclusions

2024 ASCO Annual Meeting

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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