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Environmental Health and Preventive Medicine

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Open Access 01-12-2021 | Research article

Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Authors: Yuki Mizuno, Hana Shimizu-Furusawa, Shoko Konishi, Tsukasa Inaoka, Sk Akhtar Ahmad, Makiko Sekiyama, Oekan S. Abdoellah, Budhi Gunawan, Rajendra Prasad Parajuli, Yukio Ikemoto, Tran Dinh Lam, Chiho Watanabe, Masahiro Umezaki

Published in: Environmental Health and Preventive Medicine | Issue 1/2021

Abstract

Background

Previous studies have suggested that exposures to heavy metals (arsenic, cadmium, lead, and selenium) may be associated with differences in blood pressure. However, the findings of these studies have been inconsistent. This study was performed to examine the associations between urinary heavy metal concentrations and blood pressure among residents of four Asian countries (Bangladesh, Indonesia, Nepal, and Vietnam).

Methods

This cross-sectional study examined 1899 adults in four Asian countries. Urinary concentrations of heavy metals were measured by inductively coupled plasma mass spectrometry. A questionnaire survey was administered regarding individual characteristics. Anthropometric measurements (height and weight) were performed. Systolic and diastolic blood pressures were measured after a short rest. Multiple linear regression models were applied to investigate associations between urinary heavy metal concentrations and blood pressure after adjustments for age, sex, and body mass index.

Results

The geometric means of the urinary concentrations of arsenic, cadmium, lead, and selenium were 84.6, 0.885, 2.09, and 16.5 μg/g creatinine, respectively. The urinary arsenic concentrations were slightly higher than those typically reported in non-polluted populations, while urinary cadmium, lead, and selenium concentrations were equivalent or slightly lower. The urinary lead concentrations were positively associated with both systolic and diastolic blood pressure, but urinary selenium concentrations were negatively associated with them.

Conclusions

Variations in the urinary concentrations of lead and selenium were associated with blood pressure at low levels of exposure/intake.

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Title: Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries
Authors: Yuki Mizuno
Hana Shimizu-Furusawa
Shoko Konishi
Tsukasa Inaoka
Sk Akhtar Ahmad
Makiko Sekiyama
Oekan S. Abdoellah
Budhi Gunawan
Rajendra Prasad Parajuli
Yukio Ikemoto
Tran Dinh Lam
Chiho Watanabe
Masahiro Umezaki
Publication date: 01-12-2021
Publisher: BioMed Central
Published in: Environmental Health and Preventive Medicine / Issue 1/2021
Print ISSN: 1342-078X
Electronic ISSN: 1347-4715
DOI: https://doi.org/10.1186/s12199-021-01027-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Associations between urinary heavy metal concentrations and blood pressure in residents of Asian countries

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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