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Tumor Biology
Published in: Tumor Biology 5/2014

01-05-2014 | Research Article

Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil

Authors: Rubistenia Miranda Soares de Araújo, Cynthia Farias Vieira de Melo, Fidelis Manes Neto, Juarez Nóbrega da Silva, Leonardo Ferreira Soares, Marilia de Arruda Cardoso Smith, Edilson Carvalho Sousa Jr., Rommel Mario Rodríguez Burbano, Arnaldo Correia de Medeiros, Eleonidas Moura Lima

Published in: Tumor Biology | Issue 5/2014

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Abstract

Cancer is a multifactorial disease with a high mortality rate in Brazil and worldwide. Gastric cancer (GC) is considered the fourth type of malignancy more frequent in the population worldwide and the second leading cause of death. This work aimed to evaluate single nucleotide polymorphisms (SNPs) of IFNGR1, GSTT1, and GSTP1 genes samples in gastric cancer. We analyzed 60 samples of gastric cancer, 26 diffuse and 34 intestinal types, totaling 120 alleles for each SNP. The results were obtained by PCR and allele-specific PCR. Statistical analyzes performed using BioEstat 5.0 software, applying the Fisher’s exact test and chi-square. Only the SNP gene GSTP1 (rs1695) were significantly associated with gastric cancer in the samples analyzed (χ 2 = 8.73, P < 0.05). Our results suggest that the GSTP1 gene SNP (rs1695) can be considered a risk factor associated with gastric carcinogenesis.
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Metadata
Title
Association study of SNPs of genes IFNGR1 (rs137854905), GSTT1 (rs71748309), and GSTP1 (rs1695) in gastric cancer development in samples of patient in the northern and northeastern Brazil
Authors
Rubistenia Miranda Soares de Araújo
Cynthia Farias Vieira de Melo
Fidelis Manes Neto
Juarez Nóbrega da Silva
Leonardo Ferreira Soares
Marilia de Arruda Cardoso Smith
Edilson Carvalho Sousa Jr.
Rommel Mario Rodríguez Burbano
Arnaldo Correia de Medeiros
Eleonidas Moura Lima
Publication date
01-05-2014
Publisher
Springer Netherlands
Published in
Tumor Biology / Issue 5/2014
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-014-1656-z

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