Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
BMC Cancer
Published in: BMC Cancer 1/2023

Open Access 01-12-2023 | Research

Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility

Authors: Shuyong Yu, Jiajia Cheng, Ping Li, Le Tian, Zhuang Chen, Zhaowei Chen, Yongyu Li, Jian Song

Published in: BMC Cancer | Issue 1/2023

Login to get access

Abstract

Background

Colorectal cancer (CRC) is one of the most common malignant tumors, influenced by several genetic loci in its clinical phenotypes. The aim of this study was to determine the relationship between the MMP8 gene polymorphism and CRC risk in the Chinese Han population.

Method

This study recruited 688 CRC patients and 690 healthy controls. The relationship between MMP8 polymorphism and CRC susceptibility was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI) after stratifying by age, gender, body mass index (BMI), smoking, and alcohol consumption under a multi-genetic model.

Results

MMP8 rs3740938 was associated with increased CRC predisposition (p = 0.016, OR = 1.24, 95% CI: 1.04–1.48), and this association was detected particularly in subjects aged > 60 years, females, people with BMI > 24 kg/m2, smokers, and drinkers. Moreover, rs3740938 was found to be associated with the pathological type of rectal cancer.

Conclusions

Our results first displayed that rs3740938 in MMP8 was a risk factor for CRC predisposition. This finding may provide a new biological perspective for understanding the role of the MMP8 gene in CRC pathogenesis.
Appendix
Available only for authorised users
Literature
1.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global Cancer statistics 2020: GLOBOCAN estimates of incidence and Mortality Worldwide for 36 cancers in 185 countries. Cancer J Clin. 2021;71(3):209–49.CrossRef
2.
Maomao C, He L, Dianqin S, Siyi H, Xinxin Y, Fan Y, Shaoli Z, Changfa X, Lin L, Ji P, et al. Current cancer burden in China: epidemiology, etiology, and prevention. Cancer Biology & Medicine. 2022;19(8):1121–38.CrossRef
3.
Qu R, Ma Y, Zhang Z, Fu W. Increasing burden of Colorectal cancer in China. Lancet Gastroenterol Hepatol. 2022;7(8):700.CrossRefPubMed
4.
Biller LH, Schrag D. Diagnosis and treatment of metastatic Colorectal Cancer: a review. JAMA. 2021;325(7):669–85.CrossRefPubMed
5.
Global regional. National burden of Colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the global burden of Disease Study 2019. Lancet Gastroenterol Hepatol. 2022;7(7):627–47.CrossRef
6.
Thomas M, Sakoda LC, Hoffmeister M, Rosenthal EA, Lee JK, van Duijnhoven FJB, Platz EA, Wu AH, Dampier CH, de la Chapelle A, et al. Genome-wide modeling of polygenic risk score in Colorectal Cancer Risk. Am J Hum Genet. 2020;107(3):432–44.CrossRefPubMedCentralPubMed
7.
Meng Y, Du M, Gu D, Li C, Li S, Zhang Q, Ben S, Zhu Q, Xin J, Zhang Z, et al. Genome-Wide Association Analyses Identify CATSPERE as a mediator of Colorectal Cancer susceptibility and progression. Cancer Res. 2022;82(6):986–97.CrossRefPubMed
8.
Bassiouni W, Ali MAM, Schulz R. Multifunctional intracellular matrix metalloproteinases: implications in Disease. FEBS J. 2021;288(24):7162–82.CrossRefPubMed
9.
10.
Juurikka K, Dufour A, Pehkonen K, Mainoli B, Campioni Rodrigues P, Solis N, Klein T, Nyberg P, Overall CM, Salo T, et al. MMP8 increases tongue carcinoma cell-cell adhesion and diminishes migration via cleavage of anti-adhesive FXYD5. Oncogenesis. 2021;10(5):44.CrossRefPubMedCentralPubMed
11.
Reijonen P, Peltonen R, Tervahartiala T, Sorsa T, Isoniemi H. Serum Matrix Metalloproteinase-8 and Myeloperoxidase Predict Survival after Resection of Colorectal Liver metastases. Oncology. 2021;99(12):766–79.CrossRefPubMed
12.
Pezeshkian Z, Nobili S, Peyravian N, Shojaee B, Nazari H, Soleimani H, Asadzadeh-Aghdaei H, Ashrafian Bonab M, Nazemalhosseini-Mojarad E, Mini E. Insights into the role of Matrix metalloproteinases in Precancerous conditions and in Colorectal Cancer. Cancers. 2021;13(24):6226.CrossRefPubMedCentralPubMed
13.
Bartnykaitė A, Savukaitytė A, Bekampytė J, Ugenskienė R, Laukaitienė D, Korobeinikova E, Gudaitienė J, Juozaitytė E. The role of Matrix Metalloproteinase single-nucleotide polymorphisms in the Clinicopathological properties of Breast Cancer. Biomedicines. 2022;10(8):1891.CrossRefPubMedCentralPubMed
14.
Murugan AK, Qasem E, Al-Hindi H, Alzahrani AS. Analysis of ALK, IDH1, IDH2 and MMP8 somatic mutations in differentiated thyroid cancers. Mol Clin Oncol. 2021;15(4):210.CrossRefPubMedCentralPubMed
15.
Insodaite R, Liutkevicius V, Uloza V, Solovejute R, Smalinskiene A. Association between MMP8 gene polymorphisms and laryngeal squamous cell carcinoma. Anticancer Res. 2020;40(4):2003–9.CrossRefPubMed
16.
Tai J, Sun D, Wang X, Kang Z. Matrix metalloproteinase-8 rs11225395 polymorphism correlates with Colorectal cancer risk and survival in a Chinese Han population: a case-control study. Aging. 2020;12(19):19618–27.CrossRefPubMedCentralPubMed
17.
Deng Y, Ke TW, Wang YC, Chin YT, Yueh TC, Hung YC, Mong MC, Yang YC, Chang WS, Shen TC, et al. Impact of Matrix Metalloproteinase-8 genotypes on Colorectal Cancer Risk in Taiwan. Anticancer Res. 2023;43(9):3979–85.CrossRefPubMed
18.
Wang K, Zhou Y, Li G, Wen X, Kou Y, Yu J, He H, Zhao Q, Xue F, Wang J, et al. MMP8 and MMP9 gene polymorphisms were associated with Breast cancer risk in a Chinese Han population. Sci Rep. 2018;8(1):13422.CrossRefPubMedCentralPubMed
19.
Dvornyk V, Ponomarenko I, Minyaylo O, Reshetnikov E, Churnosov M. Association of the functionally significant polymorphisms of the MMP9 gene with H. Pylori-positive gastric Ulcer in the caucasian population of Central Russia. PLoS ONE. 2021;16(9):e0257060.CrossRefPubMedCentralPubMed
20.
Zhao Y, Zhang Q, Zhang X, Zhang Y, Lu Y, Ma X, Li W, Niu X, Zhang G, Chang M, et al. The roles of MMP8/MMP10 polymorphisms in ischemic Stroke susceptibility. Brain and Behavior. 2022;12(12):e2797.CrossRefPubMedCentralPubMed
21.
Oeth P, del Mistro G, Marnellos G, Shi T, van den Boom D. Qualitative and quantitative genotyping using single base primer extension coupled with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MassARRAY). Methods in Molecular Biology (Clifton NJ). 2009;578:307–43.CrossRef
22.
Ellis JA, Ong B. The MassARRAY(®) system for targeted SNP genotyping. Methods in Molecular Biology (Clifton NJ). 2017;1492:77–94.CrossRef
23.
Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N. Assessing the probability that a positive report is false: an approach for molecular epidemiology studies. J Natl Cancer Inst. 2004;96(6):434–42.CrossRefPubMedCentralPubMed
24.
Hagman H, Bendahl PO, Lidfeldt J, Belting M, Johnsson A. Protein array profiling of circulating angiogenesis-related factors during bevacizumab containing treatment in metastatic Colorectal cancer. PLoS ONE. 2018;13(12):e0209838.CrossRefPubMedCentralPubMed
25.
Ochman B, Mielcarska S, Kula A, Dawidowicz M, Robotycka J, Piecuch J, Szrot M, Dzięgielewska-Gęsiak S, Muc-Wierzgoń M, Waniczek D, et al. Do elevated YKL-40 levels drive the immunosuppressive Tumor Microenvironment in Colorectal Cancer? Assessment of the Association of the expression of YKL-40, MMP-8, IL17A, and PD-L1 with coexisting type 2 Diabetes, obesity, and active Smoking. Curr Issues Mol Biol. 2023;45(4):2781–97.CrossRefPubMedCentralPubMed
26.
Forsberg A, Westerberg M, Metcalfe C, Steele R, Blom J, Engstrand L, Fritzell K, Hellström M, Levin L, Löwbeer C, et al. Once-only colonoscopy or two rounds of faecal immunochemical testing 2 years apart for Colorectal cancer screening (SCREESCO): preliminary report of a randomised controlled trial. Lancet Gastroenterol Hepatol. 2022;7(6):513–21.CrossRefPubMed
27.
Siegel RL, Miller KD, Goding Sauer A, Fedewa SA, Butterly LF, Anderson JC, Cercek A, Smith RA, Jemal A. Colorectal cancer statistics, 2020. Cancer J Clin. 2020;70(3):145–64.CrossRef
28.
Bull CJ, Bell JA, Murphy N, Sanderson E, Davey Smith G, Timpson NJ, Banbury BL, Albanes D, Berndt SI, Bézieau S, et al. Adiposity, metabolites, and Colorectal cancer risk: mendelian randomization study. BMC Med. 2020;18(1):396.CrossRefPubMedCentralPubMed
29.
Larsson SC, Carter P, Kar S, Vithayathil M, Mason AM, Michaëlsson K, Burgess S. Smoking, alcohol consumption, and cancer: a mendelian randomisation study in UK Biobank and international genetic consortia participants. PLoS Med. 2020;17(7):e1003178.CrossRefPubMedCentralPubMed
30.
Botteri E, Borroni E, Sloan EK, Bagnardi V, Bosetti C, Peveri G, Santucci C, Specchia C, van den Brandt P, Gallus S, et al. Smoking and Colorectal Cancer risk, overall and by Molecular subtypes: a Meta-analysis. Am J Gastroenterol. 2020;115(12):1940–9.CrossRefPubMed
31.
Sapkota R, Zakaria J, Glenn E, Richard H, Rimawi A, Tobi M, McVicker B. Alcohol Use and the risk of colorectal liver Metastasis: a systematic mapping review. Biology. 2023;12(2):257.CrossRefPubMedCentralPubMed
Metadata
Title
Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility
Authors
Shuyong Yu
Jiajia Cheng
Ping Li
Le Tian
Zhuang Chen
Zhaowei Chen
Yongyu Li
Jian Song
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2023
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-023-11662-z

Other articles of this Issue 1/2023

BMC Cancer 1/2023 Go to the issue

Research

Construction and validation of a nomogram to predict the overall survival of small cell lung cancer: a multicenter retrospective study in Shandong province, China

Research

Nanoparticle delivery of TFOs is a novel targeted therapy for HER2 amplified breast cancer

Research

Association between pancreatic cancer and diabetes: insights from a retrospective cohort study

Research

SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer

Research

TIGIT+ NK cells in combination with specific gut microbiota features predict response to checkpoint inhibitor therapy in melanoma patients

Research

Mesenchymal circulating tumor cells and Ki67: their mutual correlation and prognostic implications in hepatocellular carcinoma
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits