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International Urology and Nephrology
Published in: International Urology and Nephrology 2/2008

01-06-2008 | Original Article

Association of various sperm parameters with unexplained repeated early pregnancy loss—which is most important?

Author: Sudhindra Mohan Bhattacharya

Published in: International Urology and Nephrology | Issue 2/2008

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Abstract

Objectives

To study the relationship of various sperm characteristics with repeated unexplained early pregnancy loss.

Basic procedure

Semen samples from husbands of 74 couples with the history of repeated early pregnancy loss were analyzed as per WHO criteria, and DNA integrity was studied in each case by Acridine Orange staining test. Semen samples from 65 husbands of proven fertility were also studied for comparison.

Main findings

No statistically significant differences were noted in the age of the husbands, sperm concentration, total count per ejaculate, and rapid progressive motility of sperms between the two groups. On the other hand, significant differences were found in total motile sperms per ejaculate, percentage of motile sperm and, most importantly, in the DNA integrity value.

Conclusion

The sperm DNA-integrity damage is an important paternal factor associated with repeated embryonic or early fetal loss and should be included in the evaluation of these couples.
Literature
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World Health Organization (1999): WHO laboratory manual for the examination of human semen and sperm-cervical interaction, 4th edn. Cambridge University Press, Cambridge, UK
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Tejada RI, Mitchell JC, Norman A et al (1984) A test for the practical evaluation of male fertility by Acridine Orange (AO) fluorescence. Fertil Steril 42:87–91PubMed
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Metadata
Title
Association of various sperm parameters with unexplained repeated early pregnancy loss—which is most important?
Author
Sudhindra Mohan Bhattacharya
Publication date
01-06-2008
Publisher
Springer Netherlands
Published in
International Urology and Nephrology / Issue 2/2008
Print ISSN: 0301-1623
Electronic ISSN: 1573-2584
DOI
https://doi.org/10.1007/s11255-007-9282-y

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