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01-02-2018 | Original Article

Association of variants in microRNA with Parkinson’s disease in Chinese Han population

Authors: Fang Li, Han Liu, Yuan Cheng, Jing Yang, Yutao Liu, Yanlin Wang, Zhihua Yang, Changhe Shi, Yuming Xu

Published in: Neurological Sciences | Issue 2/2018

Abstract

MicroRNAs (miRNAs) are short RNAs regulating gene expression and may participate in pathogenesis of various diseases. Recently, rs897984:T > C in miR-4519 and rs11651671:A > G in miR-548at-5p have been reported that associate with Parkinson’s disease (PD). However, to our knowledge, there is no further evidence regarding this finding. Herein, we performed a case-control study of 546 PD patients and 550 healthy controls to genotype the two single-nucleotide polymorphisms (SNPs) to assess their associations with PD. The results showed that rs897984 (OR value for C allele = 0.851, 95% CI 0.603–1.201, P = 0.358) in miR-4519 and rs11651671 (OR value for G allele = 1.405, 95% CI 0.927–2.131, P = 0.107) in miR-548at-5p were not associated to PD, which suggest they may not contribute to the gene susceptibility of PD at least in Chinese Han population. More evidences from larger sample size and other ethnic populations are still needed to illustrate the association between miRNAs and PD.

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Title: Association of variants in microRNA with Parkinson’s disease in Chinese Han population
Authors: Fang Li
Han Liu
Yuan Cheng
Jing Yang
Yutao Liu
Yanlin Wang
Zhihua Yang
Changhe Shi
Yuming Xu
Publication date: 01-02-2018
Publisher: Springer Milan
Published in: Neurological Sciences / Issue 2/2018
Print ISSN: 1590-1874
Electronic ISSN: 1590-3478
DOI: https://doi.org/10.1007/s10072-017-3210-4

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of variants in microRNA with Parkinson’s disease in Chinese Han population

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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