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European Archives of Oto-Rhino-Laryngology

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01-02-2012 | Rhinology

Association of PPAR polymorphisms with cytokine levels in allergic rhinitis

Authors: Magdolna Krasznai, Kinga Szaniszlo, Helga Kraxner, Eszter Vargha, Margit Kovacs, Edit Kaszas, Gyorgyi Mezei, Endre Cserhati, Zoltan Borocz, Karoly Cseh

Published in: European Archives of Oto-Rhino-Laryngology | Issue 2/2012

Abstract

Our aim was to study the association of Pro12Ala and exon6 C161T polymorphisms of PPARgamma and intron7 G/C polymorphisms of PPAR-alpha with clinical symptoms, peak nasal inspiratory flow values, serum soluble TNF-alpha, TNF-R1, Fas, Fas ligand and IgE concentrations in patients with seasonal allergic rhinitis during and after pollen season. We performed a follow-up study of 66 Hungarian patients with seasonal allergic rhinitis and 180 healthy referent subjects. We used PCR-RFLP technique and ELISA. The distribution of mutant alleles of PPAR-gamma and -alpha did not differ in patients and referent subjects. Patients carrying the mutant 12Ala, exon6 161T alleles of PPAR-gamma and intron7 C allele of PPAR-alpha had significantly higher clinical symptom score values, TNF-alpha and IgE levels and lower peak nasal inspiratory flow values during and after pollen season. The results indicated that nuclear receptors PPAR-gamma and PPAR-alpha are involved in the regulation of inflammatory mediator production in patients with seasonal allergic rhinitis and polymorphisms of the receptors are very likely to contribute to the heterogeneity of clinical and immunological parameters of allergic patients.

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Title: Association of PPAR polymorphisms with cytokine levels in allergic rhinitis
Authors: Magdolna Krasznai
Kinga Szaniszlo
Helga Kraxner
Eszter Vargha
Margit Kovacs
Edit Kaszas
Gyorgyi Mezei
Endre Cserhati
Zoltan Borocz
Karoly Cseh
Publication date: 01-02-2012
Publisher: Springer-Verlag
Published in: European Archives of Oto-Rhino-Laryngology / Issue 2/2012
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-011-1710-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of PPAR polymorphisms with cytokine levels in allergic rhinitis

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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