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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2012

Open Access 01-12-2012 | Research

Association of interleukin-18 gene polymorphism with body mass index in women

Authors: Hye-Lin Kim, Sung One Cho, Seon-Young Kim, Sung-Hoon Kim, Won-Seok Chung, Seok-Hee Chung, Sung-Soo Kim, Seong-Gyu Ko, Chang-Hyun Jeong, Su-Jin Kim, Seung-Heon Hong, Jae-Young Um

Published in: Reproductive Biology and Endocrinology | Issue 1/2012

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Abstract

Background

Interleukin (IL)-18 is an important regulator of innate and acquired immune responses and has multiple roles in chronic inflammation and autoimmune disorders. Obesity is characterized by low- grade chronic inflammation. IL-18 has been suggested as an adipogenic cytokine that is associated with excess adiposity. The purpose of this study is to evaluate the relationship between IL-18 gene polymorphisms (−137 G/C and −607 C/A) and obesity.

Methods

All 680 subjects were genotyped for the polymorphisms of IL-18 gene promoters (at positions −137 G/C and −607 C/A) using a polymerase chain reaction (271 cases with BMI ≥25 kg/m2 and 409 controls with BMI <25 kg/m2). A chi-square test was used to compare the genotype and allele frequencies between the cases and control populations.

Results

Analyses of the genotype distributions revealed that IL-18 –607 C/A polymorphism was associated with an increase in body mass index in obese women in the Korean population (chi(2) = 12.301, df = 2, p = 0.015).

Conclusion

Carriage of the A allele at position −607 in the promoter of the IL-18 gene may have a role in the development of obesity.
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Metadata
Title
Association of interleukin-18 gene polymorphism with body mass index in women
Authors
Hye-Lin Kim
Sung One Cho
Seon-Young Kim
Sung-Hoon Kim
Won-Seok Chung
Seok-Hee Chung
Sung-Soo Kim
Seong-Gyu Ko
Chang-Hyun Jeong
Su-Jin Kim
Seung-Heon Hong
Jae-Young Um
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2012
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-10-31

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