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Open Access 01-04-2014 | Poster presentation

Association of initial intracellular signalling pathway and cytokine level with early mortality in severe sepsis patients

Authors: KC Lie, D Widodo, S Lardo, Eppy, R Sinto

Published in: Critical Care | Special Issue 2/2014

Excerpt

Sepsis occurs as a result of systemic inflammatory process. The release of bacterial components to the systemic circulation leads to activation of inhibitor kappa B kinase (IKK)-β and nuclear factor kappa B (NF-κB) through phosphorylation and ubiquitination. Excessive inflammatory process with maladaptive host's immune response leads to organ dysfunctions and death [1, 2]. This study was designed to investigate association of the initial level of intracellular signalling pathway and cytokine involved in sepsis pathophysiology (that is, IKK-β, NF-κB, tumour necrosis factor (TNF)α) and 72-hour (early) mortality in severe sepsis patients. …

Coldewey SM, Rogazzo M, Collino M, Patel NSA, Thiemermann C: Inhibition of IkB kinase reduces the multiple organ dysfunction caused by sepsis in the mouse. Dis Mode Mech 2013, 6: 1031-1042. 10.1242/dmm.012435CrossRef

Liu SF, Malik AB: NFkB activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 2006, 290: L622-L645. 10.1152/ajplung.00477.2005CrossRefPubMed

Title: Association of initial intracellular signalling pathway and cytokine level with early mortality in severe sepsis patients
Authors: KC Lie
D Widodo
S Lardo
Eppy
R Sinto
Publication date: 01-04-2014
Publisher: BioMed Central
Published in: Critical Care / Issue Special Issue 2/2014
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc14049

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Association of initial intracellular signalling pathway and cytokine level with early mortality in severe sepsis patients

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Keynote webinar | Spotlight on medication adherence

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