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Open Access 01-12-2012 | Research

Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

Authors: Nan Zhao, Xin Liu, Yongqin Wang, Xiaoqiu Liu, Jiana Li, Litian Yu, Liyuan Ma, Shuyu Wang, Hongye Zhang, Lisheng Liu, Jingbo Zhao, Xingyu Wang

Published in: Journal of Neuroinflammation | Issue 1/2012

Abstract

Background

Inflammatory mechanisms are important in stroke risk, and genetic variations in components of the inflammatory response have been implicated as risk factors for stroke. We tested the inflammatory gene polymorphisms and their association with ischemic stroke in a Chinese Han population.

Methods

A total of 1,124 ischemic stroke cases and 1,163 controls were genotyped with inflammatory panel strips containing 51 selected inflammatory gene polymorphisms from 35 candidate genes. We tested the genotype-stroke association with logistic regression model.

Results

We found two single nucleotide polymorphisms (SNPs) in CCL11 were associated with ischemic stroke. After adjusting for multiple testing using false discovery rate (FDR) with a 0.20 cut-off point, CCL11 rs4795895 remained statistically significant. We further stratified the study population by their hypertension status. In the hypertensive group, CCR2 rs1799864, CCR5 rs1799987 and CCL11 rs4795895 were nominally associated with increased risk of stroke. In the non-hypertensive group, CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 and CCL11 rs4795895 were associated with ischemic stroke. After correction for multiple testing, CCR2 rs1799864 and CCR5 rs1799987 remained significant in the hypertensive group, and CCL11 rs3744508, LTC4S rs730012, FCER1B rs569108, TGFB1 rs1800469, LTA rs909253 remained significant in the non-hypertensive group.

Conclusions

Our results indicate that inflammatory genetic variants are associated with increased risk of ischemic stroke in a Chinese Han population, particularly in non-hypertensive individuals.

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Title: Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population
Authors: Nan Zhao
Xin Liu
Yongqin Wang
Xiaoqiu Liu
Jiana Li
Litian Yu
Liyuan Ma
Shuyu Wang
Hongye Zhang
Lisheng Liu
Jingbo Zhao
Xingyu Wang
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Neuroinflammation / Issue 1/2012
Electronic ISSN: 1742-2094
DOI: https://doi.org/10.1186/1742-2094-9-162

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of inflammatory gene polymorphisms with ischemic stroke in a Chinese Han population

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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