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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2006

Open Access 01-02-2006 | Research article

Association of functional variants of PTPN22 and tp53in psoriatic arthritis: a case-control study

Authors: Christopher Butt, Lynette Peddle, Celia Greenwood, Sean Hamilton, Dafna Gladman, Proton Rahman

Published in: Arthritis Research & Therapy | Issue 1/2006

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Abstract

Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases, including rheumatoid arthritis, suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci, investigation of these genes in psoriatic arthritis (PsA) is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland, Canada and an admixed Caucasian PsA cohort from Toronto, Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of PTPN22 with PsA, further studies in other PsA populations are warranted.
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Metadata
Title
Association of functional variants of PTPN22 and tp53in psoriatic arthritis: a case-control study
Authors
Christopher Butt
Lynette Peddle
Celia Greenwood
Sean Hamilton
Dafna Gladman
Proton Rahman
Publication date
01-02-2006
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2006
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1880

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Keynote webinar | Spotlight on medication adherence

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