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Pediatric Surgery International

Published in:

01-03-2011 | Original Article

Association of circulating osteopontin levels with clinical outcomes in postoperative biliary atresia

Authors: Sittisak Honsawek, Paisarn Vejchapipat, Voranush Chongsrisawat, Nutchanart Thawornsuk, Yong Poovorawan

Published in: Pediatric Surgery International | Issue 3/2011

Abstract

Purpose

Biliary atresia (BA) is one of the most serious liver disorders in children. The aims of the present study were to investigate circulating levels of osteopontin in BA children compared with healthy controls and to evaluate the relationship between circulating osteopontin and therapeutic outcome of BA patients.

Methods

Fifty-nine BA patients post-Kasai operation and 13 healthy children were recruited. The patients were divided into two groups according to their serum total bilirubin levels (TB < 2, jaundice-free vs. TB ≥ 2 mg/dL, persistent jaundice) and alanine aminotransferase (ALT < 45, normal ALT vs. ALT ≥ 45 IU/L, elevated ALT). Plasma osteopontin levels were analyzed using commercial enzyme-linked immunosorbent assay.

Results

The circulating osteopontin was higher in BA children compared with that of healthy controls (146.9 ± 19.1 vs. 28.0 ± 8.4 ng/mL, P = 0.001). The BA patients with persistent jaundice had more increased plasma osteopontin levels than those without jaundice (157.8 ± 47.9 vs. 27.5 ± 6.4 ng/mL, P = 0.001). Furthermore, plasma osteopontin levels in BA patients with elevated ALT were significantly higher than those with normal ALT (103.2 ± 29.2 vs. 24.5 ± 7.9 ng/mL, P = 0.01). In addition, circulating osteopontin was positively correlated with serum total bilirubin (r = 0.526, P < 0.001) and with serum ALT (r = 0.575, P < 0.001). Subsequent analysis showed that the BA patients with portal hypertension had more elevated plasma osteopontin compared to those without portal hypertension (116.7 ± 31.1 vs. 19.5 ± 9.3 ng/mL, P = 0.01).

Conclusion

Increased circulating osteopontin was associated with the development of hepatic dysfunction and portal hypertension in BA patients. Circulating osteopontin may serve as a possible marker reflecting disease severity and monitoring the disease progression in postoperative BA patients.

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Title: Association of circulating osteopontin levels with clinical outcomes in postoperative biliary atresia
Authors: Sittisak Honsawek
Paisarn Vejchapipat
Voranush Chongsrisawat
Nutchanart Thawornsuk
Yong Poovorawan
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: Pediatric Surgery International / Issue 3/2011
Print ISSN: 0179-0358
Electronic ISSN: 1437-9813
DOI: https://doi.org/10.1007/s00383-010-2799-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association of circulating osteopontin levels with clinical outcomes in postoperative biliary atresia

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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