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International Ophthalmology

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01-12-2017 | Review

Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis

Authors: Mohammad Hossein Jabbarpoor Bonyadi, Mehdi Yaseri, Mortaza Bonyadi, Masoud Soheilian

Published in: International Ophthalmology | Issue 6/2017

Abstract

Purpose

To compare the published results of studies on the genotype association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V in cases diagnosed as retinal angiomatous proliferation (RAP) versus neovascular age-related macular degeneration (AMD) or healthy controls.

Methods

Heterogeneity of studies was evaluated using Cochran’s Q test and I-square index. To modify the heterogeneity in the variables, we used random effects model. Meta-analysis was performed using STATA.

Results

Four studies were included with 1076 neovascular AMD patients, 222 RAP cases, and 2276 control subjects. Pooled overall odds ratios for RAP/AMD were 1.15 (95% CI 0.60–2.18) for GT versus GG, 3.52 (95% CI 1.25–9.91) for TT versus GG ARMS2, 0.98 (95% CI 0.22–4.29) for GA versus AA, 1.00 (95% CI 0.25–4.02) for GG versus AA CFHI62V, 0.57 (95% CI 0.35–0.93) for CT versus TT CFH Y402H, and 0.40 (95% CI 0.22–0.74) for CC versus TT CFH Y402H. Regression analysis showed that ARMS2 TT genotype has a statistically significant effect on RAP versus AMD compared to CFH genotypes (P < 0.001).

Conclusion

This meta-analysis disclosed a stronger effect of ARMS2 genotypes in RAP cases compared with CFH Y402H and I62V genotypes.

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Title: Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis
Authors: Mohammad Hossein Jabbarpoor Bonyadi
Mehdi Yaseri
Mortaza Bonyadi
Masoud Soheilian
Publication date: 01-12-2017
Publisher: Springer Netherlands
Published in: International Ophthalmology / Issue 6/2017
Print ISSN: 0165-5701
Electronic ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-016-0413-2

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Association of ARMS2/LOC387715 A69S, CFH Y402H, and CFH I62V polymorphisms with retinal angiomatous proliferation compared with typical age-related macular degeneration: a meta-analysis

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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