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01-11-2016 | Original Article

Association between XRCC3 Thr241Met polymorphism and nasopharyngeal carcinoma risk: evidence from a large-scale case-control study and a meta-analysis

Authors: Qian Cui, Xiao-Yu Zuo, Yi-Fan Lian, Qi-Sheng Feng, Yun-Fei Xia, Cai-Yun He, Li-Zhen Chen, Wei-Hua Jia, Hai-Qiang Mai, Yi-Xin Zeng, Jin-Xin Bei

Published in: Tumor Biology | Issue 11/2016

Abstract

The X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism (rs861539, C > T) has drawn wide attentions as its association with cancer risk and its involvement in DNA repair. Several studies have attempted to link rs861539 to nasopharyngeal cancer (NPC) risk; however, the sample sizes of these studies are small and the results are controversial. To investigate the relationship of rs861539 and NPC susceptibility, we conducted a large-scale case-control study involving 4001 NPC cases and 2967 controls of southern Chinese. Logistic regression analysis revealed significant association for rs861539 and NPC risk under the recessive model (TT vs. CT + CC) with adjustment of age and gender (odds ratio, OR = 2.72; 95 % CI 1.10–6.72; P = 0.03). Further, meta-analysis involving 4457 NPC cases and 4132 controls from four studies showed consistent association of TT carriers and NPC risk (OR = 3.12; 95 % CI 1.58–6.13; P = 0.001). Taken together, our findings based on large-scale sample size suggested rs861539 at XRCC3 to be associated with NPC risk through recessive model.

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Title: Association between XRCC3 Thr241Met polymorphism and nasopharyngeal carcinoma risk: evidence from a large-scale case-control study and a meta-analysis
Authors: Qian Cui
Xiao-Yu Zuo
Yi-Fan Lian
Qi-Sheng Feng
Yun-Fei Xia
Cai-Yun He
Li-Zhen Chen
Wei-Hua Jia
Hai-Qiang Mai
Yi-Xin Zeng
Jin-Xin Bei
Publication date: 01-11-2016
Publisher: Springer Netherlands
Published in: Tumor Biology / Issue 11/2016
Print ISSN: 1010-4283
Electronic ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-016-5300-y

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