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BMC Neurology

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Open Access 01-12-2020 | Research article

Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease

Authors: Ziqi Liu, Shihao He, Zongsheng Xu, Ran Duan, Li Yuan, Chu Xiao, Zhe Yi, Rong Wang

Published in: BMC Neurology | Issue 1/2020

Abstract

Background

Ischemic Moyamoya disease is one of the important causes of stroke, which leads to severe impairment in cognitive functions. This cognitive impairment occurs prior to stroke. However, the cognitive functions that are impaired and the mechanisms of these impairments have not been determined.

Methods

We analyzed 12 patients with Moyamoya disease and 12 controls. All participants underwent cognitive tests and magnetic resonance imaging (MRI) scans. The diffusion tensor imaging (DTI) data was processed using Tract-Based Spatial Statistics (TBSS). Significantly different white matter areas were correlated with different cognitive functions.

Results

There were significant differences in intelligence and subtraction between the patients and controls (p < 0.05). The parameters of DTI such as fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) have different changes in anterior thalamic radiation, inferior fronto-occipital fasciculus (IFO), superior longitudinal fasciculus (SLF), uncinate fasciculus (UF), inferior longitudinal fasciculus, forceps minor, and other regions between the two groups.

Conclusion

Left UF and IFO may be the key brain regions affecting arithmetic function, while bilateral IFO has an effect on intelligence. RD and AD may be better indicators for early prediction of chronic white matter damage than FA, while MD tends to have a comprehensive indirect change. There is cognitive impairment in ischemic MMD, which is closely related to white matter impairment.

Trial registration

Clinical Trial Registration, Unique identifier: ChiCTR1900023610. Registered 4 June 2019 – Prospective study registered.

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Title: Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease
Authors: Ziqi Liu
Shihao He
Zongsheng Xu
Ran Duan
Li Yuan
Chu Xiao
Zhe Yi
Rong Wang
Publication date: 01-12-2020
Publisher: BioMed Central
Published in: BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-020-01876-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Association between white matter impairment and cognitive dysfunction in patients with ischemic Moyamoya disease

Abstract

Background

Methods

Results

Conclusion

Trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

Trial registration

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